Coffee acutely increases sympathetic nerve activity and blood pressure independently of caffeine content: Role of habitual versus nonhabitual drinking
Coffee is the most abundantly consumed stimulant worldwide. However, its cardiovascular safety remains controversial. Possible health hazards have been related to its main ingredient, caffeine. Activation of the sympathetic nervous system by coffee may enhance cardiovascular risk; however, it is unc...
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Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2002-12, Vol.106 (23), p.2935-2940 |
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creator | CORTI, Roberto BINGGELI, Christian SUDANO, Isabella SPIEKER, Lukas HÄNSELER, Edgar RUSCHITZKA, Frank CHAPLIN, William F LÜSCHER, Thomas F NOLL, Georg |
description | Coffee is the most abundantly consumed stimulant worldwide. However, its cardiovascular safety remains controversial. Possible health hazards have been related to its main ingredient, caffeine. Activation of the sympathetic nervous system by coffee may enhance cardiovascular risk; however, it is unclear whether this effect of coffee is related to caffeine or other substance(s) also contained in decaffeinated coffee.
In 15 healthy volunteers (6 habitual and 9 nonhabitual coffee drinkers) arterial blood pressure (BP), heart rate, and muscle sympathetic nervous activity (MSA) were continuously recorded before and after drinking a triple espresso or a decaffeinated triple espresso or after intravenous administration of caffeine (250 mg) or placebo (saline) in the same subjects. There was a significant time x condition interaction for the intravenous caffeine and placebo conditions for MSA, with caffeine showing a significant increase in MSA at 60 minutes (53.2+/-14.1% total activity) and the placebo group showing no effect. A similar significant time effect was found for coffee drinking (54.1+/-22.5% total activity). Habitual and nonhabitual coffee drinkers demonstrated similar changes in MSA and BP after intravenous caffeine, whereas coffee drinking increased BP in nonhabitual drinkers only, despite comparable increases of MSA and plasma caffeine levels. Nonhabitual coffee drinkers showed similar activation of MSA and BP after caffeine infusion, coffee, or decaffeinated coffee.
Acutely, coffee and caffeine induced comparable increases in MSA and BP in nonhabitual coffee drinkers, whereas habitual coffee drinkers exhibited lack of BP increase despite MSA activation to coffee. Because decaffeinated coffee also increases BP and MSA in nonhabitual drinkers, ingredients other than caffeine must be responsible for cardiovascular activation. |
doi_str_mv | 10.1161/01.CIR.0000046228.97025.3A |
format | Article |
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In 15 healthy volunteers (6 habitual and 9 nonhabitual coffee drinkers) arterial blood pressure (BP), heart rate, and muscle sympathetic nervous activity (MSA) were continuously recorded before and after drinking a triple espresso or a decaffeinated triple espresso or after intravenous administration of caffeine (250 mg) or placebo (saline) in the same subjects. There was a significant time x condition interaction for the intravenous caffeine and placebo conditions for MSA, with caffeine showing a significant increase in MSA at 60 minutes (53.2+/-14.1% total activity) and the placebo group showing no effect. A similar significant time effect was found for coffee drinking (54.1+/-22.5% total activity). Habitual and nonhabitual coffee drinkers demonstrated similar changes in MSA and BP after intravenous caffeine, whereas coffee drinking increased BP in nonhabitual drinkers only, despite comparable increases of MSA and plasma caffeine levels. Nonhabitual coffee drinkers showed similar activation of MSA and BP after caffeine infusion, coffee, or decaffeinated coffee.
Acutely, coffee and caffeine induced comparable increases in MSA and BP in nonhabitual coffee drinkers, whereas habitual coffee drinkers exhibited lack of BP increase despite MSA activation to coffee. Because decaffeinated coffee also increases BP and MSA in nonhabitual drinkers, ingredients other than caffeine must be responsible for cardiovascular activation.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.0000046228.97025.3A</identifier><identifier>PMID: 12460875</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Administration, Oral ; Adult ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Caffeine - administration & dosage ; Caffeine - pharmacology ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Coffee - chemistry ; Electrocardiography - drug effects ; Feeding Behavior ; Hemodynamics - drug effects ; Hemodynamics - physiology ; Humans ; Injections, Intravenous ; Medical sciences ; Muscles - innervation ; Peroneal Nerve - drug effects ; Peroneal Nerve - physiology ; Reference Values ; Sympathetic Nervous System - drug effects ; Sympathetic Nervous System - physiology ; Time Factors</subject><ispartof>Circulation (New York, N.Y.), 2002-12, Vol.106 (23), p.2935-2940</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Dec 3, 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-34f7069e4e2fcd3f58d08dfe792a74407bdf6899c488e150f03fc00f09d7b803</citedby><cites>FETCH-LOGICAL-c415t-34f7069e4e2fcd3f58d08dfe792a74407bdf6899c488e150f03fc00f09d7b803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14921810$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12460875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CORTI, Roberto</creatorcontrib><creatorcontrib>BINGGELI, Christian</creatorcontrib><creatorcontrib>SUDANO, Isabella</creatorcontrib><creatorcontrib>SPIEKER, Lukas</creatorcontrib><creatorcontrib>HÄNSELER, Edgar</creatorcontrib><creatorcontrib>RUSCHITZKA, Frank</creatorcontrib><creatorcontrib>CHAPLIN, William F</creatorcontrib><creatorcontrib>LÜSCHER, Thomas F</creatorcontrib><creatorcontrib>NOLL, Georg</creatorcontrib><title>Coffee acutely increases sympathetic nerve activity and blood pressure independently of caffeine content: Role of habitual versus nonhabitual drinking</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Coffee is the most abundantly consumed stimulant worldwide. However, its cardiovascular safety remains controversial. Possible health hazards have been related to its main ingredient, caffeine. Activation of the sympathetic nervous system by coffee may enhance cardiovascular risk; however, it is unclear whether this effect of coffee is related to caffeine or other substance(s) also contained in decaffeinated coffee.
In 15 healthy volunteers (6 habitual and 9 nonhabitual coffee drinkers) arterial blood pressure (BP), heart rate, and muscle sympathetic nervous activity (MSA) were continuously recorded before and after drinking a triple espresso or a decaffeinated triple espresso or after intravenous administration of caffeine (250 mg) or placebo (saline) in the same subjects. There was a significant time x condition interaction for the intravenous caffeine and placebo conditions for MSA, with caffeine showing a significant increase in MSA at 60 minutes (53.2+/-14.1% total activity) and the placebo group showing no effect. A similar significant time effect was found for coffee drinking (54.1+/-22.5% total activity). Habitual and nonhabitual coffee drinkers demonstrated similar changes in MSA and BP after intravenous caffeine, whereas coffee drinking increased BP in nonhabitual drinkers only, despite comparable increases of MSA and plasma caffeine levels. Nonhabitual coffee drinkers showed similar activation of MSA and BP after caffeine infusion, coffee, or decaffeinated coffee.
Acutely, coffee and caffeine induced comparable increases in MSA and BP in nonhabitual coffee drinkers, whereas habitual coffee drinkers exhibited lack of BP increase despite MSA activation to coffee. Because decaffeinated coffee also increases BP and MSA in nonhabitual drinkers, ingredients other than caffeine must be responsible for cardiovascular activation.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Caffeine - administration & dosage</subject><subject>Caffeine - pharmacology</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Coffee - chemistry</subject><subject>Electrocardiography - drug effects</subject><subject>Feeding Behavior</subject><subject>Hemodynamics - drug effects</subject><subject>Hemodynamics - physiology</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Medical sciences</subject><subject>Muscles - innervation</subject><subject>Peroneal Nerve - drug effects</subject><subject>Peroneal Nerve - physiology</subject><subject>Reference Values</subject><subject>Sympathetic Nervous System - drug effects</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Time Factors</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd1q3DAQhU1paTZpX6GIQHtnV3-25NwtS38CgULIvZDlUaPUK7mSvLAv0ueN3CxdqC40zMx3jgSnqq4JbgjpyGdMmt3tfYPXwztKZdMLTNuGbV9VG9JSXvOW9a-rTdn3tWCUXlSXKT2VtmOifVtdEMo7LEW7qf7sgrUASJslw3REzpsIOkFC6bifdX6E7AzyEA8rk93B5SPSfkTDFMKI5ggpLRGKboQZyuVzcQkWGV18nQdkgs9leoPuwwTr5lEPLi96QgeIaUnIB_9vNEbnfzn_8131xuopwftTvaoevn552H2v7358u91t72rDSZtrxq3AXQ8cqDUjs60csRwtiJ5qwTkWw2g72feGSwmkxRYza3Ap_SgGidlV9enFdo7h9wIpq71LBqZJewhLUoIKJohYwev_wKewRF--piihnaCSygLdvEAmhpQiWDVHt9fxqAhWa3IKE1WSU-fk1N_kFNsW8YfTC8uwh_EsPUVVgI8nQCejJxu1Ny6dOd5TIglmzwCWpPc</recordid><startdate>20021203</startdate><enddate>20021203</enddate><creator>CORTI, Roberto</creator><creator>BINGGELI, Christian</creator><creator>SUDANO, Isabella</creator><creator>SPIEKER, Lukas</creator><creator>HÄNSELER, Edgar</creator><creator>RUSCHITZKA, Frank</creator><creator>CHAPLIN, William F</creator><creator>LÜSCHER, Thomas F</creator><creator>NOLL, Georg</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20021203</creationdate><title>Coffee acutely increases sympathetic nerve activity and blood pressure independently of caffeine content: Role of habitual versus nonhabitual drinking</title><author>CORTI, Roberto ; BINGGELI, Christian ; SUDANO, Isabella ; SPIEKER, Lukas ; HÄNSELER, Edgar ; RUSCHITZKA, Frank ; CHAPLIN, William F ; LÜSCHER, Thomas F ; NOLL, Georg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-34f7069e4e2fcd3f58d08dfe792a74407bdf6899c488e150f03fc00f09d7b803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Caffeine - administration & dosage</topic><topic>Caffeine - pharmacology</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Coffee - chemistry</topic><topic>Electrocardiography - drug effects</topic><topic>Feeding Behavior</topic><topic>Hemodynamics - drug effects</topic><topic>Hemodynamics - physiology</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Medical sciences</topic><topic>Muscles - innervation</topic><topic>Peroneal Nerve - drug effects</topic><topic>Peroneal Nerve - physiology</topic><topic>Reference Values</topic><topic>Sympathetic Nervous System - drug effects</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CORTI, Roberto</creatorcontrib><creatorcontrib>BINGGELI, Christian</creatorcontrib><creatorcontrib>SUDANO, Isabella</creatorcontrib><creatorcontrib>SPIEKER, Lukas</creatorcontrib><creatorcontrib>HÄNSELER, Edgar</creatorcontrib><creatorcontrib>RUSCHITZKA, Frank</creatorcontrib><creatorcontrib>CHAPLIN, William F</creatorcontrib><creatorcontrib>LÜSCHER, Thomas F</creatorcontrib><creatorcontrib>NOLL, Georg</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CORTI, Roberto</au><au>BINGGELI, Christian</au><au>SUDANO, Isabella</au><au>SPIEKER, Lukas</au><au>HÄNSELER, Edgar</au><au>RUSCHITZKA, Frank</au><au>CHAPLIN, William F</au><au>LÜSCHER, Thomas F</au><au>NOLL, Georg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coffee acutely increases sympathetic nerve activity and blood pressure independently of caffeine content: Role of habitual versus nonhabitual drinking</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2002-12-03</date><risdate>2002</risdate><volume>106</volume><issue>23</issue><spage>2935</spage><epage>2940</epage><pages>2935-2940</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Coffee is the most abundantly consumed stimulant worldwide. However, its cardiovascular safety remains controversial. Possible health hazards have been related to its main ingredient, caffeine. Activation of the sympathetic nervous system by coffee may enhance cardiovascular risk; however, it is unclear whether this effect of coffee is related to caffeine or other substance(s) also contained in decaffeinated coffee.
In 15 healthy volunteers (6 habitual and 9 nonhabitual coffee drinkers) arterial blood pressure (BP), heart rate, and muscle sympathetic nervous activity (MSA) were continuously recorded before and after drinking a triple espresso or a decaffeinated triple espresso or after intravenous administration of caffeine (250 mg) or placebo (saline) in the same subjects. There was a significant time x condition interaction for the intravenous caffeine and placebo conditions for MSA, with caffeine showing a significant increase in MSA at 60 minutes (53.2+/-14.1% total activity) and the placebo group showing no effect. A similar significant time effect was found for coffee drinking (54.1+/-22.5% total activity). Habitual and nonhabitual coffee drinkers demonstrated similar changes in MSA and BP after intravenous caffeine, whereas coffee drinking increased BP in nonhabitual drinkers only, despite comparable increases of MSA and plasma caffeine levels. Nonhabitual coffee drinkers showed similar activation of MSA and BP after caffeine infusion, coffee, or decaffeinated coffee.
Acutely, coffee and caffeine induced comparable increases in MSA and BP in nonhabitual coffee drinkers, whereas habitual coffee drinkers exhibited lack of BP increase despite MSA activation to coffee. Because decaffeinated coffee also increases BP and MSA in nonhabitual drinkers, ingredients other than caffeine must be responsible for cardiovascular activation.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>12460875</pmid><doi>10.1161/01.CIR.0000046228.97025.3A</doi><tpages>6</tpages></addata></record> |
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subjects | Administration, Oral Adult Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Blood Pressure - physiology Caffeine - administration & dosage Caffeine - pharmacology Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Coffee - chemistry Electrocardiography - drug effects Feeding Behavior Hemodynamics - drug effects Hemodynamics - physiology Humans Injections, Intravenous Medical sciences Muscles - innervation Peroneal Nerve - drug effects Peroneal Nerve - physiology Reference Values Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiology Time Factors |
title | Coffee acutely increases sympathetic nerve activity and blood pressure independently of caffeine content: Role of habitual versus nonhabitual drinking |
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