Local anaesthesia in elective inguinal hernia repair: A randomised, double-blind study comparing the efficacy of levobupivacaine with racemic bupivacaine
Objective: To assess the use of infiltration with local anaesthetics levobupivacaine and bupivacaine, during inguinal hernia repair. Design: Double‐blind, randomised study. Setting: Postgraduate medical school, United Kingdom. Subjects: 69 male patients aged 18 years or older. Interventions: Wound i...
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| Veröffentlicht in: | The European journal of surgery 2002-01, Vol.168 (7), p.391-396 |
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| container_title | The European journal of surgery |
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| creator | Kingsnorth, Andrew N. Cummings, Chris G. Bennett, David H. |
| description | Objective:
To assess the use of infiltration with local anaesthetics levobupivacaine and bupivacaine, during inguinal hernia repair.
Design:
Double‐blind, randomised study.
Setting:
Postgraduate medical school, United Kingdom.
Subjects:
69 male patients aged 18 years or older.
Interventions:
Wound infiltration with 0.25% levobupivacaine and 0.25% racemic bupivacaine.
Main outcome measures:
Area under the curve (AUC) of visual analogue scale (VAS) scores for postoperative pain at rest in the supine position, rising from the supine to the sitting position, and walking, against time for both treatment groups.
Results:
There were no significant differences between treatment groups for the AUC of VAS scores for postoperative pain, global verbal pain rating or time to first dose of analgesic medication.
Conclusions:
Levobupivacaine exerts a similar anaesthetic and analgesic effect to racemic bupivacaine when infiltrated both intraoperatively and during the early postoperative period for elective inguinal hernia repair. |
| doi_str_mv | 10.1080/110241502320789069 |
| format | Article |
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To assess the use of infiltration with local anaesthetics levobupivacaine and bupivacaine, during inguinal hernia repair.
Design:
Double‐blind, randomised study.
Setting:
Postgraduate medical school, United Kingdom.
Subjects:
69 male patients aged 18 years or older.
Interventions:
Wound infiltration with 0.25% levobupivacaine and 0.25% racemic bupivacaine.
Main outcome measures:
Area under the curve (AUC) of visual analogue scale (VAS) scores for postoperative pain at rest in the supine position, rising from the supine to the sitting position, and walking, against time for both treatment groups.
Results:
There were no significant differences between treatment groups for the AUC of VAS scores for postoperative pain, global verbal pain rating or time to first dose of analgesic medication.
Conclusions:
Levobupivacaine exerts a similar anaesthetic and analgesic effect to racemic bupivacaine when infiltrated both intraoperatively and during the early postoperative period for elective inguinal hernia repair.</description><identifier>ISSN: 1102-4151</identifier><identifier>EISSN: 1741-9271</identifier><identifier>DOI: 10.1080/110241502320789069</identifier><identifier>PMID: 12463428</identifier><language>eng</language><publisher>UK: Taylor & Francis, Ltd</publisher><subject>Abdominal surgery. Urology. Gynecology. Obstetrics ; Adolescent ; Adult ; analgesia ; Analysis of Variance ; Anesthesia ; Anesthesia depending on type of surgery ; Anesthesia, Local - methods ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthetics, Local - administration & dosage ; Biological and medical sciences ; bupivacaine ; Bupivacaine - administration & dosage ; Double-Blind Method ; elective inguinal hernia repair ; Elective Surgical Procedures ; Follow-Up Studies ; Hernia, Inguinal - diagnosis ; Hernia, Inguinal - surgery ; Humans ; Laparoscopy - methods ; levobupivacaine ; local anaesthesia ; Male ; Medical sciences ; Middle Aged ; Pain Measurement ; Pain, Postoperative - physiopathology ; Patient Satisfaction ; randomised ; Statistics, Nonparametric ; Treatment Outcome ; wound infiltration</subject><ispartof>The European journal of surgery, 2002-01, Vol.168 (7), p.391-396</ispartof><rights>Copyright © 2002 Taylor and Francis Ltd</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4572-cd545c57c33355b2a2a9752c3c717dddb500b06b5aa7d722caa7d4346291bc1d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14008886$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12463428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kingsnorth, Andrew N.</creatorcontrib><creatorcontrib>Cummings, Chris G.</creatorcontrib><creatorcontrib>Bennett, David H.</creatorcontrib><title>Local anaesthesia in elective inguinal hernia repair: A randomised, double-blind study comparing the efficacy of levobupivacaine with racemic bupivacaine</title><title>The European journal of surgery</title><addtitle>Eur J Surg</addtitle><description>Objective:
To assess the use of infiltration with local anaesthetics levobupivacaine and bupivacaine, during inguinal hernia repair.
Design:
Double‐blind, randomised study.
Setting:
Postgraduate medical school, United Kingdom.
Subjects:
69 male patients aged 18 years or older.
Interventions:
Wound infiltration with 0.25% levobupivacaine and 0.25% racemic bupivacaine.
Main outcome measures:
Area under the curve (AUC) of visual analogue scale (VAS) scores for postoperative pain at rest in the supine position, rising from the supine to the sitting position, and walking, against time for both treatment groups.
Results:
There were no significant differences between treatment groups for the AUC of VAS scores for postoperative pain, global verbal pain rating or time to first dose of analgesic medication.
Conclusions:
Levobupivacaine exerts a similar anaesthetic and analgesic effect to racemic bupivacaine when infiltrated both intraoperatively and during the early postoperative period for elective inguinal hernia repair.</description><subject>Abdominal surgery. Urology. Gynecology. Obstetrics</subject><subject>Adolescent</subject><subject>Adult</subject><subject>analgesia</subject><subject>Analysis of Variance</subject><subject>Anesthesia</subject><subject>Anesthesia depending on type of surgery</subject><subject>Anesthesia, Local - methods</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anesthetics, Local - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>bupivacaine</subject><subject>Bupivacaine - administration & dosage</subject><subject>Double-Blind Method</subject><subject>elective inguinal hernia repair</subject><subject>Elective Surgical Procedures</subject><subject>Follow-Up Studies</subject><subject>Hernia, Inguinal - diagnosis</subject><subject>Hernia, Inguinal - surgery</subject><subject>Humans</subject><subject>Laparoscopy - methods</subject><subject>levobupivacaine</subject><subject>local anaesthesia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pain Measurement</subject><subject>Pain, Postoperative - physiopathology</subject><subject>Patient Satisfaction</subject><subject>randomised</subject><subject>Statistics, Nonparametric</subject><subject>Treatment Outcome</subject><subject>wound infiltration</subject><issn>1102-4151</issn><issn>1741-9271</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhS0EomXgBVggb2BFwD9xnLBrq1JAU34EiKV1Y98whiQOdjJlHoW3xdWMKBIbVvdK9zvH8jmEPOTsGWc1e845EyVXTEjBdN2wqrlFjrkuedEIzW_nPQNFJvgRuZfSN8YYl1rcJUdclJUsRX1Mfq2DhZ7CCJjmDSYP1I8Ue7Sz32Levy5-zMAG45hvESfw8QU9oRFGFwaf0D2lLixtj0Xb-9HRNC9uR20YJohZTrMrxa7zFuyOho72uA3tMvktWPAj0is_b7KbxcFb-tfhPrnTQZ_wwWGuyOeX55_OXhXrdxevz07WhS2VFoV1qlRWaSulVKoVIKDRSlhpNdfOuVYx1rKqVQDaaSHs9SxlWYmGt5Y7uSJP9r5TDD-WnILJv7LY9zBiWJLRQkvV5ORWROxBG0NKETszRT9A3BnOzHUh5t9CsujRwX1pB3Q3kkMDGXh8ACDlJrqcq_XphisZq-u6ypzac1e-x91_PG3O33wUIuuKvc6nGX_-0UH8biottTJf3l6YS3764f3luja1_A3JsLNs</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Kingsnorth, Andrew N.</creator><creator>Cummings, Chris G.</creator><creator>Bennett, David H.</creator><general>Taylor & Francis, Ltd</general><general>Taylor & Francis</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>Local anaesthesia in elective inguinal hernia repair: A randomised, double-blind study comparing the efficacy of levobupivacaine with racemic bupivacaine</title><author>Kingsnorth, Andrew N. ; Cummings, Chris G. ; Bennett, David H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4572-cd545c57c33355b2a2a9752c3c717dddb500b06b5aa7d722caa7d4346291bc1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Abdominal surgery. Urology. Gynecology. Obstetrics</topic><topic>Adolescent</topic><topic>Adult</topic><topic>analgesia</topic><topic>Analysis of Variance</topic><topic>Anesthesia</topic><topic>Anesthesia depending on type of surgery</topic><topic>Anesthesia, Local - methods</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthetics, Local - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>bupivacaine</topic><topic>Bupivacaine - administration & dosage</topic><topic>Double-Blind Method</topic><topic>elective inguinal hernia repair</topic><topic>Elective Surgical Procedures</topic><topic>Follow-Up Studies</topic><topic>Hernia, Inguinal - diagnosis</topic><topic>Hernia, Inguinal - surgery</topic><topic>Humans</topic><topic>Laparoscopy - methods</topic><topic>levobupivacaine</topic><topic>local anaesthesia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pain Measurement</topic><topic>Pain, Postoperative - physiopathology</topic><topic>Patient Satisfaction</topic><topic>randomised</topic><topic>Statistics, Nonparametric</topic><topic>Treatment Outcome</topic><topic>wound infiltration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kingsnorth, Andrew N.</creatorcontrib><creatorcontrib>Cummings, Chris G.</creatorcontrib><creatorcontrib>Bennett, David H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The European journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kingsnorth, Andrew N.</au><au>Cummings, Chris G.</au><au>Bennett, David H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local anaesthesia in elective inguinal hernia repair: A randomised, double-blind study comparing the efficacy of levobupivacaine with racemic bupivacaine</atitle><jtitle>The European journal of surgery</jtitle><addtitle>Eur J Surg</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>168</volume><issue>7</issue><spage>391</spage><epage>396</epage><pages>391-396</pages><issn>1102-4151</issn><eissn>1741-9271</eissn><abstract>Objective:
To assess the use of infiltration with local anaesthetics levobupivacaine and bupivacaine, during inguinal hernia repair.
Design:
Double‐blind, randomised study.
Setting:
Postgraduate medical school, United Kingdom.
Subjects:
69 male patients aged 18 years or older.
Interventions:
Wound infiltration with 0.25% levobupivacaine and 0.25% racemic bupivacaine.
Main outcome measures:
Area under the curve (AUC) of visual analogue scale (VAS) scores for postoperative pain at rest in the supine position, rising from the supine to the sitting position, and walking, against time for both treatment groups.
Results:
There were no significant differences between treatment groups for the AUC of VAS scores for postoperative pain, global verbal pain rating or time to first dose of analgesic medication.
Conclusions:
Levobupivacaine exerts a similar anaesthetic and analgesic effect to racemic bupivacaine when infiltrated both intraoperatively and during the early postoperative period for elective inguinal hernia repair.</abstract><cop>UK</cop><pub>Taylor & Francis, Ltd</pub><pmid>12463428</pmid><doi>10.1080/110241502320789069</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The European journal of surgery, 2002-01, Vol.168 (7), p.391-396 |
| issn | 1102-4151 1741-9271 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Abdominal surgery. Urology. Gynecology. Obstetrics Adolescent Adult analgesia Analysis of Variance Anesthesia Anesthesia depending on type of surgery Anesthesia, Local - methods Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Local - administration & dosage Biological and medical sciences bupivacaine Bupivacaine - administration & dosage Double-Blind Method elective inguinal hernia repair Elective Surgical Procedures Follow-Up Studies Hernia, Inguinal - diagnosis Hernia, Inguinal - surgery Humans Laparoscopy - methods levobupivacaine local anaesthesia Male Medical sciences Middle Aged Pain Measurement Pain, Postoperative - physiopathology Patient Satisfaction randomised Statistics, Nonparametric Treatment Outcome wound infiltration |
| title | Local anaesthesia in elective inguinal hernia repair: A randomised, double-blind study comparing the efficacy of levobupivacaine with racemic bupivacaine |
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