Immobilization-induced changes in erythrocyte membrane fluidity in rabbits: a spin-label electron spin resonance study

It has been shown that many diseases are linked to abnormalities of the erythrocyte membrane. This study observed the changes in erythrocyte membrane fluidity during an immobilization period of 21 days. The right hindlimbs of male adult New Zealand white rabbits were immobilized for 21 days. Blood s...

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Veröffentlicht in:	Annals of clinical and laboratory science 2002-09, Vol.32 (4), p.399-403
Hauptverfasser:	Liu, Mingju, Li, Jingxian, Qin, Ling, Lee, Kwong Man, Chan, Kai Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Diseases of the osteoarticular system Electron Spin Resonance Spectroscopy Erythrocyte Membrane - metabolism Hindlimb Immobilization - adverse effects Male Medical sciences Membrane Fluidity Miscellaneous. Osteoarticular involvement in other diseases Rabbits Space life sciences Time Factors
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Zusammenfassung:	It has been shown that many diseases are linked to abnormalities of the erythrocyte membrane. This study observed the changes in erythrocyte membrane fluidity during an immobilization period of 21 days. The right hindlimbs of male adult New Zealand white rabbits were immobilized for 21 days. Blood samples were collected and heparinized prior to immobilization and on days 1, 3, 7, 14, and 21 of immobilization. The membrane fluidity of erythrocytes was measured by spin-label electron spin resonance (ESR). The membrane fluidity was expressed by the value of order parameter (S). The results showed a significant increase of S on days 7 and 14 of immobilization (p
ISSN:	0091-7370 1550-8080