DYRK3 Activation, Engagement of Protein Kinase A/cAMP Response Element-binding Protein, and Modulation of Progenitor Cell Survival

DYRKs are a new family ofdual-specificity tyrosine-regulatedkinases with emerging roles in cell growth and development. Recently, we discovered that DYRK3 is expressed primarily in erythroid progenitor cells and modulates late erythropoiesis. We now describe 1) roles for the DYRK3 YTY signature moti...

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Veröffentlicht in:	The Journal of biological chemistry 2002-12, Vol.277 (49), p.47052-47060
Hauptverfasser:	Li, Ke, Zhao, Shuqing, Karur, Vinit, Wojchowski, Don M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Animals Apoptosis Blotting, Western Cell Death Cell Line Cell Survival COS Cells Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Cytokines - metabolism DNA, Complementary - metabolism Dyrk Kinases Flow Cytometry Genes, Reporter HeLa Cells Hematopoietic Stem Cells - metabolism Humans Mice Models, Biological Molecular Sequence Data Phosphorylation Precipitin Tests Protein Binding Protein Serine-Threonine Kinases - metabolism Protein Structure, Tertiary Protein-Tyrosine Kinases - metabolism Sequence Homology, Amino Acid Serine - metabolism Signal Transduction Time Factors Transfection Tyrosine - chemistry
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