Cloning and characterisation of PKB and PRK homologs from Hydra and the evolution of the protein kinase family

Two new serine/threonine protein kinases have been cloned from Hydra cDNA. The first of these kinases belongs to the PKB/Akt family. It is expressed ubiquitously in Hydra at a relatively low level but is upregulated during head regeneration. The second kinase is a member of the PRK/PKN family. It is...

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Veröffentlicht in:	Development genes and evolution 2002-12, Vol.212 (11), p.513-519
Hauptverfasser:	Herold, Michaela, Cikala, Mihai, MacWilliams, Harry, David, Charles N, Böttger, Angelika
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Amino Acid Sequence Animals Binding Sites Cloning Cloning, Molecular Dictyostelium Escherichia coli - enzymology Escherichia coli - genetics Evolution, Molecular Homology Hydra Hydra - classification Hydra - enzymology Hydra - genetics Kinases Molecular Sequence Data Molecular Weight N-Terminus Phylogeny Pleckstrin PRK protein Protein kinase C Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Recombinant Proteins - chemistry Recombinant Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Sequence Alignment Sequence Homology, Amino Acid
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