A wide interindividual variability of urinary 6beta-hydroxycortisol to free cortisol in 487 healthy Japanese subjects in near basal condition
The frequency distribution of CYP3A activity was investigated by measuring ratios of urinary 6beta-hydroxycortisol to free cortisol in 487 healthy subjects to determine whether a genetic polymorphism for this cytochrome enzyme exists in "native-born" Japanese persons. Spot urine samples (f...
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| Veröffentlicht in: | Therapeutic drug monitoring 2002-12, Vol.24 (6), p.722-727 |
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| creator | Inagaki, Kazuhiro Inagaki, Masami Kataoka, Tomomi Sekido, Izumi Gill, Mark A Nishida, Mikio |
| description | The frequency distribution of CYP3A activity was investigated by measuring ratios of urinary 6beta-hydroxycortisol to free cortisol in 487 healthy subjects to determine whether a genetic polymorphism for this cytochrome enzyme exists in "native-born" Japanese persons. Spot urine samples (from 9:00 am to 12:00 pm) were collected for measurement of 6beta-hydroxycortisol and free cortisol by high-performance liquid chromatography with a CN column after extracting with a solid-phase column (Bond-Elut C18). The frequency distribution of the urinary 6beta-hydroxycortisol to free cortisol was widely distributed among subjects but with no clear bimodality by a probit plot. Furthermore, the frequency distribution assessed on a new normal test variable plot indicated the possible existence of a CYP3A sexual dimorphism. Mean 6beta-hydroxycortisol levels were higher in women (n = 249) than in men (n = 238) by 1.7-fold, and this difference was statistically significant (P < 0.01). These results show that a CYP3A genetic polymorphism in Japanese persons, based on 6beta-hydroxycortisol excretions, likely does not exist, but there appears to be a broad unimodal distribution of enzyme activity in the population. |
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Spot urine samples (from 9:00 am to 12:00 pm) were collected for measurement of 6beta-hydroxycortisol and free cortisol by high-performance liquid chromatography with a CN column after extracting with a solid-phase column (Bond-Elut C18). The frequency distribution of the urinary 6beta-hydroxycortisol to free cortisol was widely distributed among subjects but with no clear bimodality by a probit plot. Furthermore, the frequency distribution assessed on a new normal test variable plot indicated the possible existence of a CYP3A sexual dimorphism. Mean 6beta-hydroxycortisol levels were higher in women (n = 249) than in men (n = 238) by 1.7-fold, and this difference was statistically significant (P < 0.01). These results show that a CYP3A genetic polymorphism in Japanese persons, based on 6beta-hydroxycortisol excretions, likely does not exist, but there appears to be a broad unimodal distribution of enzyme activity in the population.</description><identifier>ISSN: 0163-4356</identifier><identifier>PMID: 12451288</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Adult ; Chromatography, High Pressure Liquid ; Creatinine - urine ; Female ; Humans ; Hydrocortisone - analogs & derivatives ; Hydrocortisone - urine ; Japan ; Male ; Reference Values ; Regression Analysis ; Sex Characteristics</subject><ispartof>Therapeutic drug monitoring, 2002-12, Vol.24 (6), p.722-727</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12451288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inagaki, Kazuhiro</creatorcontrib><creatorcontrib>Inagaki, Masami</creatorcontrib><creatorcontrib>Kataoka, Tomomi</creatorcontrib><creatorcontrib>Sekido, Izumi</creatorcontrib><creatorcontrib>Gill, Mark A</creatorcontrib><creatorcontrib>Nishida, Mikio</creatorcontrib><title>A wide interindividual variability of urinary 6beta-hydroxycortisol to free cortisol in 487 healthy Japanese subjects in near basal condition</title><title>Therapeutic drug monitoring</title><addtitle>Ther Drug Monit</addtitle><description>The frequency distribution of CYP3A activity was investigated by measuring ratios of urinary 6beta-hydroxycortisol to free cortisol in 487 healthy subjects to determine whether a genetic polymorphism for this cytochrome enzyme exists in "native-born" Japanese persons. Spot urine samples (from 9:00 am to 12:00 pm) were collected for measurement of 6beta-hydroxycortisol and free cortisol by high-performance liquid chromatography with a CN column after extracting with a solid-phase column (Bond-Elut C18). The frequency distribution of the urinary 6beta-hydroxycortisol to free cortisol was widely distributed among subjects but with no clear bimodality by a probit plot. Furthermore, the frequency distribution assessed on a new normal test variable plot indicated the possible existence of a CYP3A sexual dimorphism. Mean 6beta-hydroxycortisol levels were higher in women (n = 249) than in men (n = 238) by 1.7-fold, and this difference was statistically significant (P < 0.01). These results show that a CYP3A genetic polymorphism in Japanese persons, based on 6beta-hydroxycortisol excretions, likely does not exist, but there appears to be a broad unimodal distribution of enzyme activity in the population.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Creatinine - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocortisone - analogs & derivatives</subject><subject>Hydrocortisone - urine</subject><subject>Japan</subject><subject>Male</subject><subject>Reference Values</subject><subject>Regression Analysis</subject><subject>Sex Characteristics</subject><issn>0163-4356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1OwzAQhHMA0VJ4BeQTt0j-i-Mcq4pfVeIA92hjb1RXaRxsp5CH4J0JonBaafbTzGjOsiVlSuRSFGqRXca4p5RJTelFtmBcFoxrvcy-1uTDWSSuTxhcb93R2RE6coTgoHGdSxPxLRnnH4SJqAYT5LvJBv85GR-Si74jyZM2IJJ_wfVE6pLsELq0m8gzDNBjRBLHZo8mxR-gRwikgTiHGT8HJ-f7q-y8hS7i9emustf7u7fNY759eXjarLf5UEidM1sUxgKiNhVXWlJRSdsgaMorpqCUjIOqJLW8tUpaoSgyKbgRvDG8MmKV3f66DsG_jxhTfXDRYNfNJf0Y65KXgglNZ_DmBI7NAW09BHeYV6j_5hPfW3NtSw</recordid><startdate>200212</startdate><enddate>200212</enddate><creator>Inagaki, Kazuhiro</creator><creator>Inagaki, Masami</creator><creator>Kataoka, Tomomi</creator><creator>Sekido, Izumi</creator><creator>Gill, Mark A</creator><creator>Nishida, Mikio</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200212</creationdate><title>A wide interindividual variability of urinary 6beta-hydroxycortisol to free cortisol in 487 healthy Japanese subjects in near basal condition</title><author>Inagaki, Kazuhiro ; Inagaki, Masami ; Kataoka, Tomomi ; Sekido, Izumi ; Gill, Mark A ; Nishida, Mikio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p548-1d55cdaee8c926840394dbea802916a7412a6940d2fd64d360e1432c32bc29c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Creatinine - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocortisone - analogs & derivatives</topic><topic>Hydrocortisone - urine</topic><topic>Japan</topic><topic>Male</topic><topic>Reference Values</topic><topic>Regression Analysis</topic><topic>Sex Characteristics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inagaki, Kazuhiro</creatorcontrib><creatorcontrib>Inagaki, Masami</creatorcontrib><creatorcontrib>Kataoka, Tomomi</creatorcontrib><creatorcontrib>Sekido, Izumi</creatorcontrib><creatorcontrib>Gill, Mark A</creatorcontrib><creatorcontrib>Nishida, Mikio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Therapeutic drug monitoring</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inagaki, Kazuhiro</au><au>Inagaki, Masami</au><au>Kataoka, Tomomi</au><au>Sekido, Izumi</au><au>Gill, Mark A</au><au>Nishida, Mikio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A wide interindividual variability of urinary 6beta-hydroxycortisol to free cortisol in 487 healthy Japanese subjects in near basal condition</atitle><jtitle>Therapeutic drug monitoring</jtitle><addtitle>Ther Drug Monit</addtitle><date>2002-12</date><risdate>2002</risdate><volume>24</volume><issue>6</issue><spage>722</spage><epage>727</epage><pages>722-727</pages><issn>0163-4356</issn><abstract>The frequency distribution of CYP3A activity was investigated by measuring ratios of urinary 6beta-hydroxycortisol to free cortisol in 487 healthy subjects to determine whether a genetic polymorphism for this cytochrome enzyme exists in "native-born" Japanese persons. Spot urine samples (from 9:00 am to 12:00 pm) were collected for measurement of 6beta-hydroxycortisol and free cortisol by high-performance liquid chromatography with a CN column after extracting with a solid-phase column (Bond-Elut C18). The frequency distribution of the urinary 6beta-hydroxycortisol to free cortisol was widely distributed among subjects but with no clear bimodality by a probit plot. Furthermore, the frequency distribution assessed on a new normal test variable plot indicated the possible existence of a CYP3A sexual dimorphism. Mean 6beta-hydroxycortisol levels were higher in women (n = 249) than in men (n = 238) by 1.7-fold, and this difference was statistically significant (P < 0.01). These results show that a CYP3A genetic polymorphism in Japanese persons, based on 6beta-hydroxycortisol excretions, likely does not exist, but there appears to be a broad unimodal distribution of enzyme activity in the population.</abstract><cop>United States</cop><pmid>12451288</pmid><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Chromatography, High Pressure Liquid Creatinine - urine Female Humans Hydrocortisone - analogs & derivatives Hydrocortisone - urine Japan Male Reference Values Regression Analysis Sex Characteristics |
| title | A wide interindividual variability of urinary 6beta-hydroxycortisol to free cortisol in 487 healthy Japanese subjects in near basal condition |
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