CaT1 Contributes to the Stores-operated Calcium Current in Jurkat T-lymphocytes

T-lymphocyte activation requires sustained Ca2+ signaling dependent upon capacitative Ca2+ entry (CCE). The protein(s) that forms the stores-operated Ca2+ channel (SOCC) responsible for CCE has long been sought but has not been definitively identified. Members of the TRPV family (transient receptor...

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Veröffentlicht in:	The Journal of biological chemistry 2002-12, Vol.277 (49), p.47175-47183
Hauptverfasser:	Cui, Jie, Bian, Jin-Song, Kagan, Anna, McDonald, Thomas V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Calcium Channels - genetics Calcium Channels - metabolism Calcium Channels - physiology Capsaicin - pharmacology CHO Cells Cloning, Molecular Cricetinae DNA, Complementary - metabolism Genes, Dominant Humans Immunoblotting Inositol 1,4,5-Trisphosphate - metabolism Jurkat Cells Microscopy, Fluorescence Mutation Reverse Transcriptase Polymerase Chain Reaction Time Factors Transfection TRPV Cation Channels
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