Effect of giving up cigarette smoking and restarting in patients with clinically manifested atherosclerosis
Cigarette smoking, a key risk factor for the development of vascular disease, is associated with an increased 8-epi-prostaglandin (PG) F 2α. Elevated 8-epi-PGF 2α has been found in vascular tissue, blood and urine as well. We examined the influence of quitting cigarette smoking in 71 patients (38 ma...
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| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2002-11, Vol.67 (5), p.333-339 |
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| container_title | Prostaglandins, leukotrienes and essential fatty acids |
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| creator | Chehne, F. Oguogho, A. Lupattelli, G. Palumbo, B. Sinzinger, H. |
| description | Cigarette smoking, a key risk factor for the development of vascular disease, is associated with an increased 8-epi-prostaglandin (PG) F
2α. Elevated 8-epi-PGF
2α has been found in vascular tissue, blood and urine as well. We examined the influence of quitting cigarette smoking in 71 patients (38 males, 33 females; aged 32–67 a) with clinically manifested atherosclerosis and various risk factors. In addition, in eight patients with hypercholesterolemia without clinical manifestation of atherosclerosis quitting smoking was monitored as well. Twenty-six of the patients with manifested atherosclerosis and five with hypercholesterolemia restarted and the isoprostanes in plasma, serum and urine were monitored in these patients as well. Quitting cigarette smoking induces an immediate decline becoming significant after 1 or 2 weeks. Restarting smoking results in an increase in 8-epi-PGF
2α reaching prevalues within almost 1 week. These findings indicate that the in vivo oxidation injury associated with cigarette smoking quickly decreases after quitting but increases soon after restarting immediately. |
| doi_str_mv | 10.1054/plef.2002.0438 |
| format | Article |
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2α. Elevated 8-epi-PGF
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2α. Elevated 8-epi-PGF
2α has been found in vascular tissue, blood and urine as well. We examined the influence of quitting cigarette smoking in 71 patients (38 males, 33 females; aged 32–67 a) with clinically manifested atherosclerosis and various risk factors. In addition, in eight patients with hypercholesterolemia without clinical manifestation of atherosclerosis quitting smoking was monitored as well. Twenty-six of the patients with manifested atherosclerosis and five with hypercholesterolemia restarted and the isoprostanes in plasma, serum and urine were monitored in these patients as well. Quitting cigarette smoking induces an immediate decline becoming significant after 1 or 2 weeks. Restarting smoking results in an increase in 8-epi-PGF
2α reaching prevalues within almost 1 week. These findings indicate that the in vivo oxidation injury associated with cigarette smoking quickly decreases after quitting but increases soon after restarting immediately.</description><subject>Adult</subject><subject>Aged</subject><subject>Arteriosclerosis - blood</subject><subject>Arteriosclerosis - complications</subject><subject>Arteriosclerosis - etiology</subject><subject>Arteriosclerosis - urine</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Diabetes Complications</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - urine</subject><subject>Dinoprost - analogs & derivatives</subject><subject>F2-Isoprostanes - blood</subject><subject>F2-Isoprostanes - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Hypercholesterolemia - blood</subject><subject>Hypercholesterolemia - complications</subject><subject>Hypercholesterolemia - urine</subject><subject>Hypertension - blood</subject><subject>Hypertension - complications</subject><subject>Hypertension - urine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><subject>Smoking - blood</subject><subject>Smoking - urine</subject><subject>Smoking Cessation</subject><subject>Time Factors</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><issn>0952-3278</issn><issn>1532-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kbtrHDEQh0VIiM9O2pRBTdLtRc9dbRmM8wBDmqQWs9LorHhfkXQ2_u-j5Q5cGcGIGT4NPz4R8oGzPWdafVlHDHvBmNgzJc0rsuNaikYYIV-THeu1aKTozAW5zPkvqxjn6i254EIprXq1I_c3IaArdAn0EB_ifKDHlbp4gISlIM3Tcr8NYfY0YS6QytbGma5QIs4l08dY7qgb4xwdjOMTnWCOoaLoKZQ7TEt241ZjfkfeBBgzvj_fV-TPt5vf1z-a21_ff15_vW2c7FhpBoeaG-j6oTW9UExjK73pBqcG7n1rlPahCwqkkaZre68ZSOGVkwKk1iDkFfl82rum5d-xRrFTzA7HEWZcjtl2ohNGSl7B_Ql0NV9OGOya4gTpyXJmN71202s3vXbTWx98PG8-DhP6Z_zsswKfzgDkqiMkmF3Mz5xi9Zi2cubEYfXwEDHZ7KpOhz6m-h3WL_GlDP8BqMeX5A</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>Chehne, F.</creator><creator>Oguogho, A.</creator><creator>Lupattelli, G.</creator><creator>Palumbo, B.</creator><creator>Sinzinger, H.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Effect of giving up cigarette smoking and restarting in patients with clinically manifested atherosclerosis</title><author>Chehne, F. ; Oguogho, A. ; Lupattelli, G. ; Palumbo, B. ; Sinzinger, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-bce518a79b6892405e63d87bc4b1dd6845df7f4a3838769d50a32d4c32a355a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arteriosclerosis - blood</topic><topic>Arteriosclerosis - complications</topic><topic>Arteriosclerosis - etiology</topic><topic>Arteriosclerosis - urine</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - urine</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Diabetes Complications</topic><topic>Diabetes Mellitus - blood</topic><topic>Diabetes Mellitus - urine</topic><topic>Dinoprost - analogs & derivatives</topic><topic>F2-Isoprostanes - blood</topic><topic>F2-Isoprostanes - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Hypercholesterolemia - blood</topic><topic>Hypercholesterolemia - complications</topic><topic>Hypercholesterolemia - urine</topic><topic>Hypertension - blood</topic><topic>Hypertension - complications</topic><topic>Hypertension - urine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Smoking - adverse effects</topic><topic>Smoking - blood</topic><topic>Smoking - urine</topic><topic>Smoking Cessation</topic><topic>Time Factors</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chehne, F.</creatorcontrib><creatorcontrib>Oguogho, A.</creatorcontrib><creatorcontrib>Lupattelli, G.</creatorcontrib><creatorcontrib>Palumbo, B.</creatorcontrib><creatorcontrib>Sinzinger, H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chehne, F.</au><au>Oguogho, A.</au><au>Lupattelli, G.</au><au>Palumbo, B.</au><au>Sinzinger, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of giving up cigarette smoking and restarting in patients with clinically manifested atherosclerosis</atitle><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>67</volume><issue>5</issue><spage>333</spage><epage>339</epage><pages>333-339</pages><issn>0952-3278</issn><eissn>1532-2823</eissn><abstract>Cigarette smoking, a key risk factor for the development of vascular disease, is associated with an increased 8-epi-prostaglandin (PG) F
2α. Elevated 8-epi-PGF
2α has been found in vascular tissue, blood and urine as well. We examined the influence of quitting cigarette smoking in 71 patients (38 males, 33 females; aged 32–67 a) with clinically manifested atherosclerosis and various risk factors. In addition, in eight patients with hypercholesterolemia without clinical manifestation of atherosclerosis quitting smoking was monitored as well. Twenty-six of the patients with manifested atherosclerosis and five with hypercholesterolemia restarted and the isoprostanes in plasma, serum and urine were monitored in these patients as well. Quitting cigarette smoking induces an immediate decline becoming significant after 1 or 2 weeks. Restarting smoking results in an increase in 8-epi-PGF
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| subjects | Adult Aged Arteriosclerosis - blood Arteriosclerosis - complications Arteriosclerosis - etiology Arteriosclerosis - urine Atherosclerosis (general aspects, experimental research) Biological and medical sciences Biomarkers - blood Biomarkers - urine Blood and lymphatic vessels Cardiology. Vascular system Diabetes Complications Diabetes Mellitus - blood Diabetes Mellitus - urine Dinoprost - analogs & derivatives F2-Isoprostanes - blood F2-Isoprostanes - urine Female Humans Hypercholesterolemia - blood Hypercholesterolemia - complications Hypercholesterolemia - urine Hypertension - blood Hypertension - complications Hypertension - urine Male Medical sciences Middle Aged Risk Factors Smoking - adverse effects Smoking - blood Smoking - urine Smoking Cessation Time Factors Tobacco, tobacco smoking Toxicology |
| title | Effect of giving up cigarette smoking and restarting in patients with clinically manifested atherosclerosis |
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