HIV Nef Inhibits T Cell Migration

Nef is a viral regulatory protein of the human immunodeficiency virus (HIV) that has been shown to contribute to disease progression. Among its putative effects on T cell functions are the down-regulation of CD4 and major histocompatibility class I surface molecules. These effects occur in part via...

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Veröffentlicht in:	The Journal of biological chemistry 2002-11, Vol.277 (48), p.46079-46084
Hauptverfasser:	Choe, Evangeline Y, Schoenberger, Elena S, Groopman, Jerome E, Park, In-Woo
Format:	Artikel
Sprache:	eng
Schlagworte:	CD4-Positive T-Lymphocytes - cytology Cell Movement Chemokine CXCL12 Chemokines, CXC - physiology Gene Products, nef - metabolism Gene Products, nef - physiology Green Fluorescent Proteins Humans Jurkat Cells Luminescent Proteins - metabolism Recombinant Fusion Proteins - metabolism Signal Transduction
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