NEUTRALIZATION OF INTERLEUKIN-11 ACTIVITY DECREASES OSTEOCLAST FORMATION AND INCREASES CANCELLOUS BONE VOLUME IN OVARIECTOMIZED MICE

The issue of whether interleukin-11 (IL-11) contributes to bone loss during states of estrogen deficiency has not been previously determined. We therefore randomized ovariectomized (OVX) mice to once daily interperitoneal injections of either sheep anti-murine IL-11 Ab or normal sheep IgG (NSIgG) fo...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2002, Vol.20 (2), p.78-85
Hauptverfasser:	Shaughnessy, Stephen G., Walton, Kimberly J., Deschamps, Paula, Butcher, Martin, Beaudin, Suzanne M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Remodeling - immunology Bone Remodeling - physiology cytokines/estrogen deficiency/Interleukin-11/osteoclast formation/postmenopausal osteoporosis Estrogens - deficiency Female In Vitro Techniques Interleukin-11 - antagonists & inhibitors Interleukin-11 - physiology Mice Mice, Inbred C3H Neutralization Tests Osteoclasts - cytology Osteoclasts - immunology Ovariectomy Sheep
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