Diminished Interferon-γ Production and Responsiveness after Endotoxin Administration to Healthy Humans

To obtain insight in the capacity of the lipopolysaccharide (LPS)–tolerant host to produce interferon (IFN)–γ and to respond to this cytokine, whole blood was obtained from healthy humans before and 4 h after intravenous injection of LPS (4 ng/kg) and stimulated ex vivo. LPS exposure in vivo resulte...

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Veröffentlicht in:	The Journal of infectious diseases 2002-12, Vol.186 (12), p.1748-1753
Hauptverfasser:	Weijer, Sebastiaan, Lauw, Fanny N., Branger, Judith, van den Blink, Bernt, van der Poll, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Blood Cytokines Down-Regulation Endotoxins General aspects Health care administration Histocompatibility Antigens Class II - biosynthesis Humans Immune Tolerance Infection pathogenesis Infectious diseases Injections, Intravenous Interferon-gamma - biosynthesis Interferon-gamma - pharmacology Interferons Interleukin-12 - biosynthesis Interleukin-18 - biosynthesis Lipopolysaccharides Lipopolysaccharides - administration & dosage Lymphocytes Major Article Male Medical sciences Monocytes Monocytes - immunology Production capacity Sepsis Tumor Necrosis Factor-alpha - biosynthesis
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