Hypothalamic Pituitary Adrenal Axis and Immune Responses to Endotoxin in Rats with Chronic Adjuvant-Induced Arthritis
We investigated the effect of immune challenge with LPS in both control rats and rats with adjuvant-induced arthritis (AA). Fourteen day-AA rats showed the expected activation of the hypothalamic-pituitary adrenal axis associated with increases in vasopressin mRNA and paradoxical decreases in cortic...
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| Veröffentlicht in: | Experimental neurology 2002-11, Vol.178 (1), p.112-123 |
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| creator | Grinevich, Valery Harbuz, Michael Ma, Xin-Ming Jessop, David Tilders, Fred J.H. Lightman, Stafford L. Aguilera, Greti |
| description | We investigated the effect of immune challenge with LPS in both control rats and rats with adjuvant-induced arthritis (AA). Fourteen day-AA rats showed the expected activation of the hypothalamic-pituitary adrenal axis associated with increases in vasopressin mRNA and paradoxical decreases in corticotropin-releasing hormone (CRH) mRNA in parvocellular neurons of the hypothalamic paraventricular nucleus (PVN). However, following LPS there was an increase in both CRH and vasopressin mRNA in the PVN. Neither control rats nor rats with AA had measurable plasma levels of IL-6, but plasma levels of IL-1β were 2.7-fold higher in AA animals. Following LPS injection both IL-1β and IL-6 increased more markedly in AA than in control rats. Neither controls nor AA rats expressed IL-1β or IL-6 mRNA in the brain. However, following LPS these were induced in the subfornical organ, choroid plexus, and median eminence of both groups of animals. The areas expressing IL-1b mRNA were larger in the AA animals and exhibited a punctate pattern throughout the brain parenchyma and PVN. These data reveal an increased peripheral and central immunological response to LPS during the chronic inflammatory process of AA, providing a mechanism through which inflammatory disease can influence the response to a novel immunological challenge. |
| doi_str_mv | 10.1006/exnr.2002.8022 |
| format | Article |
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Fourteen day-AA rats showed the expected activation of the hypothalamic-pituitary adrenal axis associated with increases in vasopressin mRNA and paradoxical decreases in corticotropin-releasing hormone (CRH) mRNA in parvocellular neurons of the hypothalamic paraventricular nucleus (PVN). However, following LPS there was an increase in both CRH and vasopressin mRNA in the PVN. Neither control rats nor rats with AA had measurable plasma levels of IL-6, but plasma levels of IL-1β were 2.7-fold higher in AA animals. Following LPS injection both IL-1β and IL-6 increased more markedly in AA than in control rats. Neither controls nor AA rats expressed IL-1β or IL-6 mRNA in the brain. However, following LPS these were induced in the subfornical organ, choroid plexus, and median eminence of both groups of animals. The areas expressing IL-1b mRNA were larger in the AA animals and exhibited a punctate pattern throughout the brain parenchyma and PVN. These data reveal an increased peripheral and central immunological response to LPS during the chronic inflammatory process of AA, providing a mechanism through which inflammatory disease can influence the response to a novel immunological challenge.</description><identifier>ISSN: 0014-4886</identifier><identifier>EISSN: 1090-2430</identifier><identifier>DOI: 10.1006/exnr.2002.8022</identifier><identifier>PMID: 12460613</identifier><identifier>CODEN: EXNEAC</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>adjuvant-induced arthritis ; Adrenocorticotropic Hormone - blood ; Animals ; Arginine Vasopressin - genetics ; arginine-vasopressin ; Arthritis, Experimental - immunology ; Arthritis, Experimental - physiopathology ; Biological and medical sciences ; Chronic Disease ; Corticosterone - blood ; corticotropin-releasing hormone ; Corticotropin-Releasing Hormone - genetics ; Diseases of the osteoarticular system ; Gene Expression - drug effects ; Gene Expression - immunology ; hypothalamic-pituitary-adrenal axis ; Hypothalamo-Hypophyseal System - immunology ; Inflammatory joint diseases ; Injuries of the nervous system and the skull. Diseases due to physical agents ; Interleukin-1 - blood ; Interleukin-1 - genetics ; interleukin-1β ; interleukin-6 ; Interleukin-6 - blood ; Interleukin-6 - genetics ; lipopolysaccharide ; Lipopolysaccharides - pharmacology ; Male ; Medical sciences ; Neurons - physiology ; Paraventricular Hypothalamic Nucleus - immunology ; Pituitary Gland, Anterior - immunology ; Pituitary-Adrenal System - immunology ; Pro-Opiomelanocortin - genetics ; Rats ; Rats, Inbred Strains ; RNA, Messenger - analysis ; Traumas. 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Fourteen day-AA rats showed the expected activation of the hypothalamic-pituitary adrenal axis associated with increases in vasopressin mRNA and paradoxical decreases in corticotropin-releasing hormone (CRH) mRNA in parvocellular neurons of the hypothalamic paraventricular nucleus (PVN). However, following LPS there was an increase in both CRH and vasopressin mRNA in the PVN. Neither control rats nor rats with AA had measurable plasma levels of IL-6, but plasma levels of IL-1β were 2.7-fold higher in AA animals. Following LPS injection both IL-1β and IL-6 increased more markedly in AA than in control rats. Neither controls nor AA rats expressed IL-1β or IL-6 mRNA in the brain. However, following LPS these were induced in the subfornical organ, choroid plexus, and median eminence of both groups of animals. The areas expressing IL-1b mRNA were larger in the AA animals and exhibited a punctate pattern throughout the brain parenchyma and PVN. These data reveal an increased peripheral and central immunological response to LPS during the chronic inflammatory process of AA, providing a mechanism through which inflammatory disease can influence the response to a novel immunological challenge.</description><subject>adjuvant-induced arthritis</subject><subject>Adrenocorticotropic Hormone - blood</subject><subject>Animals</subject><subject>Arginine Vasopressin - genetics</subject><subject>arginine-vasopressin</subject><subject>Arthritis, Experimental - immunology</subject><subject>Arthritis, Experimental - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Corticosterone - blood</subject><subject>corticotropin-releasing hormone</subject><subject>Corticotropin-Releasing Hormone - genetics</subject><subject>Diseases of the osteoarticular system</subject><subject>Gene Expression - drug effects</subject><subject>Gene Expression - immunology</subject><subject>hypothalamic-pituitary-adrenal axis</subject><subject>Hypothalamo-Hypophyseal System - immunology</subject><subject>Inflammatory joint diseases</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>Interleukin-1 - blood</subject><subject>Interleukin-1 - genetics</subject><subject>interleukin-1β</subject><subject>interleukin-6</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - genetics</subject><subject>lipopolysaccharide</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurons - physiology</subject><subject>Paraventricular Hypothalamic Nucleus - immunology</subject><subject>Pituitary Gland, Anterior - immunology</subject><subject>Pituitary-Adrenal System - immunology</subject><subject>Pro-Opiomelanocortin - genetics</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>RNA, Messenger - analysis</subject><subject>Traumas. Diseases due to physical agents</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10EGL1DAYh_EgijuuXj1KLnrr-CbNtumxDKs7sKAseg5p8obJ0iZjkq6z396WGdiTEMjllz_hIeQjgy0DaL7iKaQtB-BbCZy_IhsGHVRc1PCabACYqISUzRV5l_MjAHSCt2_JFeOigYbVGzLfPR9jOehRT97Qn77Mvuj0THubMOiR9iefqQ6W7qdpDkgfMB9jyJhpifQ22FjiyQe6nAddMv3ry4HuDimGZa23j_OTDqXaBzsbtLRP5ZB88fk9eeP0mPHD5b4mv7_d_trdVfc_vu93_X1l6hZKxZnVTls5cDZo4LYzN4wbATed61zTOpS844Nx7TDUzJpOi8GZFqQ0jQEcXH1Nvpx3jyn-mTEXNflscBx1wDhn1fKW11J0C9yeoUkx54ROHZOflhCKgVpDqzW0WkOrNfTy4NNleR4mtC_8UnYBny9AZ6NHl3QwPr84UXesbVYnzw6XDk8ek8rGY1hy-YSmKBv9__7wD9txnFc</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>Grinevich, Valery</creator><creator>Harbuz, Michael</creator><creator>Ma, Xin-Ming</creator><creator>Jessop, David</creator><creator>Tilders, Fred J.H.</creator><creator>Lightman, Stafford L.</creator><creator>Aguilera, Greti</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Hypothalamic Pituitary Adrenal Axis and Immune Responses to Endotoxin in Rats with Chronic Adjuvant-Induced Arthritis</title><author>Grinevich, Valery ; Harbuz, Michael ; Ma, Xin-Ming ; Jessop, David ; Tilders, Fred J.H. ; Lightman, Stafford L. ; Aguilera, Greti</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-21dafad8b21ba02d9c512c4059f9f67fe8292bcf7bb31dc9a4bfc7088c6c0ebf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>adjuvant-induced arthritis</topic><topic>Adrenocorticotropic Hormone - blood</topic><topic>Animals</topic><topic>Arginine Vasopressin - genetics</topic><topic>arginine-vasopressin</topic><topic>Arthritis, Experimental - immunology</topic><topic>Arthritis, Experimental - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Corticosterone - blood</topic><topic>corticotropin-releasing hormone</topic><topic>Corticotropin-Releasing Hormone - genetics</topic><topic>Diseases of the osteoarticular system</topic><topic>Gene Expression - drug effects</topic><topic>Gene Expression - immunology</topic><topic>hypothalamic-pituitary-adrenal axis</topic><topic>Hypothalamo-Hypophyseal System - immunology</topic><topic>Inflammatory joint diseases</topic><topic>Injuries of the nervous system and the skull. Diseases due to physical agents</topic><topic>Interleukin-1 - blood</topic><topic>Interleukin-1 - genetics</topic><topic>interleukin-1β</topic><topic>interleukin-6</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-6 - genetics</topic><topic>lipopolysaccharide</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurons - physiology</topic><topic>Paraventricular Hypothalamic Nucleus - immunology</topic><topic>Pituitary Gland, Anterior - immunology</topic><topic>Pituitary-Adrenal System - immunology</topic><topic>Pro-Opiomelanocortin - genetics</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>RNA, Messenger - analysis</topic><topic>Traumas. Diseases due to physical agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grinevich, Valery</creatorcontrib><creatorcontrib>Harbuz, Michael</creatorcontrib><creatorcontrib>Ma, Xin-Ming</creatorcontrib><creatorcontrib>Jessop, David</creatorcontrib><creatorcontrib>Tilders, Fred J.H.</creatorcontrib><creatorcontrib>Lightman, Stafford L.</creatorcontrib><creatorcontrib>Aguilera, Greti</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grinevich, Valery</au><au>Harbuz, Michael</au><au>Ma, Xin-Ming</au><au>Jessop, David</au><au>Tilders, Fred J.H.</au><au>Lightman, Stafford L.</au><au>Aguilera, Greti</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypothalamic Pituitary Adrenal Axis and Immune Responses to Endotoxin in Rats with Chronic Adjuvant-Induced Arthritis</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>178</volume><issue>1</issue><spage>112</spage><epage>123</epage><pages>112-123</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><coden>EXNEAC</coden><abstract>We investigated the effect of immune challenge with LPS in both control rats and rats with adjuvant-induced arthritis (AA). Fourteen day-AA rats showed the expected activation of the hypothalamic-pituitary adrenal axis associated with increases in vasopressin mRNA and paradoxical decreases in corticotropin-releasing hormone (CRH) mRNA in parvocellular neurons of the hypothalamic paraventricular nucleus (PVN). However, following LPS there was an increase in both CRH and vasopressin mRNA in the PVN. Neither control rats nor rats with AA had measurable plasma levels of IL-6, but plasma levels of IL-1β were 2.7-fold higher in AA animals. Following LPS injection both IL-1β and IL-6 increased more markedly in AA than in control rats. Neither controls nor AA rats expressed IL-1β or IL-6 mRNA in the brain. However, following LPS these were induced in the subfornical organ, choroid plexus, and median eminence of both groups of animals. The areas expressing IL-1b mRNA were larger in the AA animals and exhibited a punctate pattern throughout the brain parenchyma and PVN. These data reveal an increased peripheral and central immunological response to LPS during the chronic inflammatory process of AA, providing a mechanism through which inflammatory disease can influence the response to a novel immunological challenge.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>12460613</pmid><doi>10.1006/exnr.2002.8022</doi><tpages>12</tpages></addata></record> |
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| ispartof | Experimental neurology, 2002-11, Vol.178 (1), p.112-123 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | adjuvant-induced arthritis Adrenocorticotropic Hormone - blood Animals Arginine Vasopressin - genetics arginine-vasopressin Arthritis, Experimental - immunology Arthritis, Experimental - physiopathology Biological and medical sciences Chronic Disease Corticosterone - blood corticotropin-releasing hormone Corticotropin-Releasing Hormone - genetics Diseases of the osteoarticular system Gene Expression - drug effects Gene Expression - immunology hypothalamic-pituitary-adrenal axis Hypothalamo-Hypophyseal System - immunology Inflammatory joint diseases Injuries of the nervous system and the skull. Diseases due to physical agents Interleukin-1 - blood Interleukin-1 - genetics interleukin-1β interleukin-6 Interleukin-6 - blood Interleukin-6 - genetics lipopolysaccharide Lipopolysaccharides - pharmacology Male Medical sciences Neurons - physiology Paraventricular Hypothalamic Nucleus - immunology Pituitary Gland, Anterior - immunology Pituitary-Adrenal System - immunology Pro-Opiomelanocortin - genetics Rats Rats, Inbred Strains RNA, Messenger - analysis Traumas. Diseases due to physical agents |
| title | Hypothalamic Pituitary Adrenal Axis and Immune Responses to Endotoxin in Rats with Chronic Adjuvant-Induced Arthritis |
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