Expansion of pre-terminally differentiated CD8 T cells in chronic HIV-positive patients presenting a rapid viral rebound during structured treatment interruption
The influence of structured treatment interruption on effector/memory CD8 T cell dynamics was analysed in chronic HIV-infected patients showing a rapid or delayed viral rebound. Structured treatment interruption consisted of at least one month of discontinuation, followed by highly active antiretrov...
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| Veröffentlicht in: | AIDS (London) 2002-12, Vol.16 (18), p.2431-2438 |
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| creator | D'OFFIZI, Gianpiero MONTESANO, Carla AGRATI, Chiara GIOIA, Cristiana AMICOSANTE, Massimo TOPINO, Simone NARCISO, Pasquale PUCILLO, Leopoldo Paolo IPPOLITO, Giuseppe POCCIA, Fabrizio |
| description | The influence of structured treatment interruption on effector/memory CD8 T cell dynamics was analysed in chronic HIV-infected patients showing a rapid or delayed viral rebound.
Structured treatment interruption consisted of at least one month of discontinuation, followed by highly active antiretroviral therapy (HAART) resumption. Two groups of HIV structured treatment interruption patients were selected on the basis of plasma viral HIV-RNA value (> 30 000 copies/ml, branched DNA): group A (n = 14), patients with a rapid viral rebound (within one month) and group B (n = 6), patients with a delayed or no viral rebound (after a minimum of 4 months).
A clinical and immunological follow-up was performed at HAART suspension (t 0), one month from suspension (t 1), at HAART resumption (t 2), and 30 days from resumption (t 3).
A sustained viral rebound was observed in group A patients, showing a rapid expansion of circulating CD8 T lymphocytes. In this group, the frequencies of CD8 T cells releasing IFN-gamma after mitogen-induced or Gag-specific stimulation were highly increased after HAART discontinuation. Nevertheless, these CD8 T lymphocytes were mainly composed of pre-terminally differentiated cytotoxic T lymphocytes (CTL) expressing a CCR7 CD27 CD45RA phenotype and a reduced amount of perforin. In contrast, group B patients showed no significant changes in immunological parameters during a prolonged drug-free period.
These data indicate that monitoring CD8 T cell dynamics during structured treatment interruption could be clinically relevant, and new therapeutic strategies should aim qualitatively to restore CTL effector functions. |
| doi_str_mv | 10.1097/00002030-200212060-00008 |
| format | Article |
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Structured treatment interruption consisted of at least one month of discontinuation, followed by highly active antiretroviral therapy (HAART) resumption. Two groups of HIV structured treatment interruption patients were selected on the basis of plasma viral HIV-RNA value (> 30 000 copies/ml, branched DNA): group A (n = 14), patients with a rapid viral rebound (within one month) and group B (n = 6), patients with a delayed or no viral rebound (after a minimum of 4 months).
A clinical and immunological follow-up was performed at HAART suspension (t 0), one month from suspension (t 1), at HAART resumption (t 2), and 30 days from resumption (t 3).
A sustained viral rebound was observed in group A patients, showing a rapid expansion of circulating CD8 T lymphocytes. In this group, the frequencies of CD8 T cells releasing IFN-gamma after mitogen-induced or Gag-specific stimulation were highly increased after HAART discontinuation. Nevertheless, these CD8 T lymphocytes were mainly composed of pre-terminally differentiated cytotoxic T lymphocytes (CTL) expressing a CCR7 CD27 CD45RA phenotype and a reduced amount of perforin. In contrast, group B patients showed no significant changes in immunological parameters during a prolonged drug-free period.
These data indicate that monitoring CD8 T cell dynamics during structured treatment interruption could be clinically relevant, and new therapeutic strategies should aim qualitatively to restore CTL effector functions.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/00002030-200212060-00008</identifier><identifier>PMID: 12461417</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; AIDS/HIV ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiretroviral Therapy, Highly Active - methods ; Antiviral agents ; Biological and medical sciences ; CD8-Positive T-Lymphocytes - virology ; Cell Transformation, Viral ; Chronic Disease ; Female ; Flow Cytometry ; HIV Infections - drug therapy ; HIV Infections - immunology ; HIV-1 - immunology ; Human viral diseases ; Humans ; Immunologic Memory ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Pilot Projects ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load</subject><ispartof>AIDS (London), 2002-12, Vol.16 (18), p.2431-2438</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-92cf6fef964caff0e515dafa2ba93bf9302cadb09ded8dc49dd36751a21b10523</citedby><cites>FETCH-LOGICAL-c422t-92cf6fef964caff0e515dafa2ba93bf9302cadb09ded8dc49dd36751a21b10523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14442879$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12461417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>D'OFFIZI, Gianpiero</creatorcontrib><creatorcontrib>MONTESANO, Carla</creatorcontrib><creatorcontrib>AGRATI, Chiara</creatorcontrib><creatorcontrib>GIOIA, Cristiana</creatorcontrib><creatorcontrib>AMICOSANTE, Massimo</creatorcontrib><creatorcontrib>TOPINO, Simone</creatorcontrib><creatorcontrib>NARCISO, Pasquale</creatorcontrib><creatorcontrib>PUCILLO, Leopoldo Paolo</creatorcontrib><creatorcontrib>IPPOLITO, Giuseppe</creatorcontrib><creatorcontrib>POCCIA, Fabrizio</creatorcontrib><title>Expansion of pre-terminally differentiated CD8 T cells in chronic HIV-positive patients presenting a rapid viral rebound during structured treatment interruption</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>The influence of structured treatment interruption on effector/memory CD8 T cell dynamics was analysed in chronic HIV-infected patients showing a rapid or delayed viral rebound.
Structured treatment interruption consisted of at least one month of discontinuation, followed by highly active antiretroviral therapy (HAART) resumption. Two groups of HIV structured treatment interruption patients were selected on the basis of plasma viral HIV-RNA value (> 30 000 copies/ml, branched DNA): group A (n = 14), patients with a rapid viral rebound (within one month) and group B (n = 6), patients with a delayed or no viral rebound (after a minimum of 4 months).
A clinical and immunological follow-up was performed at HAART suspension (t 0), one month from suspension (t 1), at HAART resumption (t 2), and 30 days from resumption (t 3).
A sustained viral rebound was observed in group A patients, showing a rapid expansion of circulating CD8 T lymphocytes. In this group, the frequencies of CD8 T cells releasing IFN-gamma after mitogen-induced or Gag-specific stimulation were highly increased after HAART discontinuation. Nevertheless, these CD8 T lymphocytes were mainly composed of pre-terminally differentiated cytotoxic T lymphocytes (CTL) expressing a CCR7 CD27 CD45RA phenotype and a reduced amount of perforin. In contrast, group B patients showed no significant changes in immunological parameters during a prolonged drug-free period.
These data indicate that monitoring CD8 T cell dynamics during structured treatment interruption could be clinically relevant, and new therapeutic strategies should aim qualitatively to restore CTL effector functions.</description><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiretroviral Therapy, Highly Active - methods</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>CD8-Positive T-Lymphocytes - virology</subject><subject>Cell Transformation, Viral</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - immunology</subject><subject>HIV-1 - immunology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunologic Memory</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Pilot Projects</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral Load</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQhS0EopfCKyBvYGfwX2J7iS6FVqrEprCNJv4Bo8QJtlPRx-FNceiFLpnNSOPvHM_oIIQZfcOoUW9pK04FJbx1xmlPyT7Sj9CBSSVI1yn2GB0o7w0xQtEz9KyU743oqNZP0RnjsmeSqQP6dfFzhVTikvAS8Jo9qT7PMcE03WEXQ_DZpxqheoeP7zW-wdZPU8ExYfstLylafHn1haxLiTXeerxCjU1QdquyK9NXDDjDGh2-jRkmnP24bMlht-X9sdS82brl5l-zhzo3UXNvW-RtrW2v5-hJgKn4F6d-jj5_uLg5XpLrTx-vju-uiZWcV2K4DX3wwfTSQgjUd6xzEICPYMQYjKDcghupcd5pZ6VxTvSqY8DZyGjHxTl6fe-75uXH5ksd5lj2YyH5ZSuD4oqLTnf_BZnupaKSNVDfgzYvpWQfhjXHGfLdwOiw5zj8zXH4l-OfkW7Sl6c_tnH27kF4Cq4Br04AFAtTyJBsLA-clJJrZcRvFiOqIw</recordid><startdate>20021206</startdate><enddate>20021206</enddate><creator>D'OFFIZI, Gianpiero</creator><creator>MONTESANO, Carla</creator><creator>AGRATI, Chiara</creator><creator>GIOIA, Cristiana</creator><creator>AMICOSANTE, Massimo</creator><creator>TOPINO, Simone</creator><creator>NARCISO, Pasquale</creator><creator>PUCILLO, Leopoldo Paolo</creator><creator>IPPOLITO, Giuseppe</creator><creator>POCCIA, Fabrizio</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20021206</creationdate><title>Expansion of pre-terminally differentiated CD8 T cells in chronic HIV-positive patients presenting a rapid viral rebound during structured treatment interruption</title><author>D'OFFIZI, Gianpiero ; MONTESANO, Carla ; AGRATI, Chiara ; GIOIA, Cristiana ; AMICOSANTE, Massimo ; TOPINO, Simone ; NARCISO, Pasquale ; PUCILLO, Leopoldo Paolo ; IPPOLITO, Giuseppe ; POCCIA, Fabrizio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-92cf6fef964caff0e515dafa2ba93bf9302cadb09ded8dc49dd36751a21b10523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiretroviral Therapy, Highly Active - methods</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>CD8-Positive T-Lymphocytes - virology</topic><topic>Cell Transformation, Viral</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - immunology</topic><topic>HIV-1 - immunology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunologic Memory</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Pilot Projects</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>D'OFFIZI, Gianpiero</creatorcontrib><creatorcontrib>MONTESANO, Carla</creatorcontrib><creatorcontrib>AGRATI, Chiara</creatorcontrib><creatorcontrib>GIOIA, Cristiana</creatorcontrib><creatorcontrib>AMICOSANTE, Massimo</creatorcontrib><creatorcontrib>TOPINO, Simone</creatorcontrib><creatorcontrib>NARCISO, Pasquale</creatorcontrib><creatorcontrib>PUCILLO, Leopoldo Paolo</creatorcontrib><creatorcontrib>IPPOLITO, Giuseppe</creatorcontrib><creatorcontrib>POCCIA, Fabrizio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>D'OFFIZI, Gianpiero</au><au>MONTESANO, Carla</au><au>AGRATI, Chiara</au><au>GIOIA, Cristiana</au><au>AMICOSANTE, Massimo</au><au>TOPINO, Simone</au><au>NARCISO, Pasquale</au><au>PUCILLO, Leopoldo Paolo</au><au>IPPOLITO, Giuseppe</au><au>POCCIA, Fabrizio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expansion of pre-terminally differentiated CD8 T cells in chronic HIV-positive patients presenting a rapid viral rebound during structured treatment interruption</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2002-12-06</date><risdate>2002</risdate><volume>16</volume><issue>18</issue><spage>2431</spage><epage>2438</epage><pages>2431-2438</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>The influence of structured treatment interruption on effector/memory CD8 T cell dynamics was analysed in chronic HIV-infected patients showing a rapid or delayed viral rebound.
Structured treatment interruption consisted of at least one month of discontinuation, followed by highly active antiretroviral therapy (HAART) resumption. Two groups of HIV structured treatment interruption patients were selected on the basis of plasma viral HIV-RNA value (> 30 000 copies/ml, branched DNA): group A (n = 14), patients with a rapid viral rebound (within one month) and group B (n = 6), patients with a delayed or no viral rebound (after a minimum of 4 months).
A clinical and immunological follow-up was performed at HAART suspension (t 0), one month from suspension (t 1), at HAART resumption (t 2), and 30 days from resumption (t 3).
A sustained viral rebound was observed in group A patients, showing a rapid expansion of circulating CD8 T lymphocytes. In this group, the frequencies of CD8 T cells releasing IFN-gamma after mitogen-induced or Gag-specific stimulation were highly increased after HAART discontinuation. Nevertheless, these CD8 T lymphocytes were mainly composed of pre-terminally differentiated cytotoxic T lymphocytes (CTL) expressing a CCR7 CD27 CD45RA phenotype and a reduced amount of perforin. In contrast, group B patients showed no significant changes in immunological parameters during a prolonged drug-free period.
These data indicate that monitoring CD8 T cell dynamics during structured treatment interruption could be clinically relevant, and new therapeutic strategies should aim qualitatively to restore CTL effector functions.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>12461417</pmid><doi>10.1097/00002030-200212060-00008</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Adult AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active - methods Antiviral agents Biological and medical sciences CD8-Positive T-Lymphocytes - virology Cell Transformation, Viral Chronic Disease Female Flow Cytometry HIV Infections - drug therapy HIV Infections - immunology HIV-1 - immunology Human viral diseases Humans Immunologic Memory Infectious diseases Male Medical sciences Middle Aged Pharmacology. Drug treatments Pilot Projects Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load |
| title | Expansion of pre-terminally differentiated CD8 T cells in chronic HIV-positive patients presenting a rapid viral rebound during structured treatment interruption |
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