Transthoracic Doppler assessment of coronary flow velocity reserve in children with Kawasaki disease: Comparison with coronary angiography and thallium-201 imaging
The purpose of this study was to determine the feasibility of coronary flow velocity reserve (CFVR) measurement by transthoracic Doppler echocardiography (TTDE) in children with Kawasaki disease (KD). Doppler-derived CFVR is a reliable marker predicting the presence of myocardial ischemia. We studie...
Gespeichert in:
| Veröffentlicht in: | Journal of the American College of Cardiology 2002-11, Vol.40 (10), p.1816-1824 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1824 |
|---|---|
| container_issue | 10 |
| container_start_page | 1816 |
| container_title | Journal of the American College of Cardiology |
| container_volume | 40 |
| creator | HIRAISHI, Satoshi HIROTA, Hamao HORIGUCHI, Yasunori TAKEDA, Nobuhiro FUJINO, Nobuyuki OGAWA, Natsuko NAKAHATA, Yayoi |
| description | The purpose of this study was to determine the feasibility of coronary flow velocity reserve (CFVR) measurement by transthoracic Doppler echocardiography (TTDE) in children with Kawasaki disease (KD).
Doppler-derived CFVR is a reliable marker predicting the presence of myocardial ischemia.
We studied 49 patients (median age 11 years) with KD. The CFVR was calculated as the ratio of hyperemic to basal peak (peak CFVR) and mean (mean CFVR) diastolic flow velocities in the posterior descending coronary artery (PD) and left anterior descending coronary artery (LAD). The CFVR measurements by TTDE were compared with the results of coronary angiography, thallium-201 (Tl-201) single-photon emission computed tomography (SPECT), and intracoronary Doppler study.
The CFVR measurements by TTDE were obtained in 92 (94%) of 98 vessels of the PD and LAD in 49 study patients. Both peak and mean CFVRs for 21 stenotic vessels were significantly smaller than those for 35 normal vessels and for 20 vessels with aneurysmal lesions (p < 0.0001). Peak and mean CFVR |
| doi_str_mv | 10.1016/S0735-1097(02)02479-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_72721437</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3242355221</sourcerecordid><originalsourceid>FETCH-LOGICAL-h301t-f70fadce9ca8e720109a19f8fabfff62058540480df6650df26bbd164198ab403</originalsourceid><addsrcrecordid>eNpd0c1u1DAQB3ALUdGl8AggSwgEh8DYiZ2YG1o-WlGJA-UcTRx74-LYqZ10tc_DixLEUqRexj78_NeMh5BnDN4yYPLdd6hLUTBQ9Wvgb4BXtSqaB2TDhGiKUqj6IdnckVPyOOdrAJANU4_IKeNVJUHKDfl1lTDkeYgJtdP0Y5wmbxLFnE3OowkzjZbqmGLAdKDWxz29NT5qNx9oMtmkW0NdoHpwvk8m0L2bB_oV95jxp6O9ywazeU-3cZwwuRyP4i4Rw87FXcJp-HPv6Tyg924ZCw6MuhF3LuyekBOLPpunx_OM_Pj86Wp7Xlx--3Kx_XBZDCWwubA1WOy1URobU6_vQSFTtrHYWWslB9GICqoGeiulWCuXXdczWTHVYFdBeUZe_c2dUrxZTJ7b0WVtvMdg4pLbmtecVWW9whf34HVcUlh7a5kAybiqlFjV86NautH07ZTWedKh_ff5K3h5BJg1ertuQrv8360tgWCi_A17NZep</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1506129495</pqid></control><display><type>article</type><title>Transthoracic Doppler assessment of coronary flow velocity reserve in children with Kawasaki disease: Comparison with coronary angiography and thallium-201 imaging</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>HIRAISHI, Satoshi ; HIROTA, Hamao ; HORIGUCHI, Yasunori ; TAKEDA, Nobuhiro ; FUJINO, Nobuyuki ; OGAWA, Natsuko ; NAKAHATA, Yayoi</creator><creatorcontrib>HIRAISHI, Satoshi ; HIROTA, Hamao ; HORIGUCHI, Yasunori ; TAKEDA, Nobuhiro ; FUJINO, Nobuyuki ; OGAWA, Natsuko ; NAKAHATA, Yayoi</creatorcontrib><description>The purpose of this study was to determine the feasibility of coronary flow velocity reserve (CFVR) measurement by transthoracic Doppler echocardiography (TTDE) in children with Kawasaki disease (KD).
Doppler-derived CFVR is a reliable marker predicting the presence of myocardial ischemia.
We studied 49 patients (median age 11 years) with KD. The CFVR was calculated as the ratio of hyperemic to basal peak (peak CFVR) and mean (mean CFVR) diastolic flow velocities in the posterior descending coronary artery (PD) and left anterior descending coronary artery (LAD). The CFVR measurements by TTDE were compared with the results of coronary angiography, thallium-201 (Tl-201) single-photon emission computed tomography (SPECT), and intracoronary Doppler study.
The CFVR measurements by TTDE were obtained in 92 (94%) of 98 vessels of the PD and LAD in 49 study patients. Both peak and mean CFVRs for 21 stenotic vessels were significantly smaller than those for 35 normal vessels and for 20 vessels with aneurysmal lesions (p < 0.0001). Peak and mean CFVR <2.0 predicted significant coronary stenosis, as determined by coronary angiography, with sensitivities and specificities of 89% and 96% and 89% and 97%, respectively. Also, both peak and mean CFVRs were correlated with reversible perfusion defects on Tl-201 SPECT (agreement 80%; kappa 0.4). The correlation between peak and mean CFVRs determined by the TTDE and intracoronary Doppler studies in 36 vessels of 23 patients were 0.76 and 0.80, respectively.
The CFVR measured by TTDE predicts the presence of significant coronary stenosis of either the right coronary artery or LAD, as well as myocardial ischemia of these territories in children with KD.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/S0735-1097(02)02479-8</identifier><identifier>PMID: 12446066</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Science</publisher><subject>Adolescent ; Adult ; Arteries - diagnostic imaging ; Arteries - physiopathology ; Biological and medical sciences ; Blood Flow Velocity - physiology ; Cardiology ; Child ; Child Welfare ; Child, Preschool ; Coronary Angiography ; Coronary Artery Bypass ; Coronary Stenosis - diagnosis ; Coronary Stenosis - epidemiology ; Coronary Stenosis - physiopathology ; Coronary vessels ; Coronary Vessels - diagnostic imaging ; Coronary Vessels - physiopathology ; Echocardiography, Doppler - methods ; Female ; Heart attacks ; Hemodynamics - physiology ; Humans ; Male ; Medical imaging ; Medical sciences ; Mucocutaneous Lymph Node Syndrome - diagnosis ; Mucocutaneous Lymph Node Syndrome - epidemiology ; Mucocutaneous Lymph Node Syndrome - physiopathology ; Observer Variation ; Predictive Value of Tests ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Sensitivity and Specificity ; Thallium Radioisotopes ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Journal of the American College of Cardiology, 2002-11, Vol.40 (10), p.1816-1824</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Elsevier Limited Nov 20, 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14030515$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12446066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HIRAISHI, Satoshi</creatorcontrib><creatorcontrib>HIROTA, Hamao</creatorcontrib><creatorcontrib>HORIGUCHI, Yasunori</creatorcontrib><creatorcontrib>TAKEDA, Nobuhiro</creatorcontrib><creatorcontrib>FUJINO, Nobuyuki</creatorcontrib><creatorcontrib>OGAWA, Natsuko</creatorcontrib><creatorcontrib>NAKAHATA, Yayoi</creatorcontrib><title>Transthoracic Doppler assessment of coronary flow velocity reserve in children with Kawasaki disease: Comparison with coronary angiography and thallium-201 imaging</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>The purpose of this study was to determine the feasibility of coronary flow velocity reserve (CFVR) measurement by transthoracic Doppler echocardiography (TTDE) in children with Kawasaki disease (KD).
Doppler-derived CFVR is a reliable marker predicting the presence of myocardial ischemia.
We studied 49 patients (median age 11 years) with KD. The CFVR was calculated as the ratio of hyperemic to basal peak (peak CFVR) and mean (mean CFVR) diastolic flow velocities in the posterior descending coronary artery (PD) and left anterior descending coronary artery (LAD). The CFVR measurements by TTDE were compared with the results of coronary angiography, thallium-201 (Tl-201) single-photon emission computed tomography (SPECT), and intracoronary Doppler study.
The CFVR measurements by TTDE were obtained in 92 (94%) of 98 vessels of the PD and LAD in 49 study patients. Both peak and mean CFVRs for 21 stenotic vessels were significantly smaller than those for 35 normal vessels and for 20 vessels with aneurysmal lesions (p < 0.0001). Peak and mean CFVR <2.0 predicted significant coronary stenosis, as determined by coronary angiography, with sensitivities and specificities of 89% and 96% and 89% and 97%, respectively. Also, both peak and mean CFVRs were correlated with reversible perfusion defects on Tl-201 SPECT (agreement 80%; kappa 0.4). The correlation between peak and mean CFVRs determined by the TTDE and intracoronary Doppler studies in 36 vessels of 23 patients were 0.76 and 0.80, respectively.
The CFVR measured by TTDE predicts the presence of significant coronary stenosis of either the right coronary artery or LAD, as well as myocardial ischemia of these territories in children with KD.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Arteries - diagnostic imaging</subject><subject>Arteries - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity - physiology</subject><subject>Cardiology</subject><subject>Child</subject><subject>Child Welfare</subject><subject>Child, Preschool</subject><subject>Coronary Angiography</subject><subject>Coronary Artery Bypass</subject><subject>Coronary Stenosis - diagnosis</subject><subject>Coronary Stenosis - epidemiology</subject><subject>Coronary Stenosis - physiopathology</subject><subject>Coronary vessels</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Coronary Vessels - physiopathology</subject><subject>Echocardiography, Doppler - methods</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Hemodynamics - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical sciences</subject><subject>Mucocutaneous Lymph Node Syndrome - diagnosis</subject><subject>Mucocutaneous Lymph Node Syndrome - epidemiology</subject><subject>Mucocutaneous Lymph Node Syndrome - physiopathology</subject><subject>Observer Variation</subject><subject>Predictive Value of Tests</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Sensitivity and Specificity</subject><subject>Thallium Radioisotopes</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0c1u1DAQB3ALUdGl8AggSwgEh8DYiZ2YG1o-WlGJA-UcTRx74-LYqZ10tc_DixLEUqRexj78_NeMh5BnDN4yYPLdd6hLUTBQ9Wvgb4BXtSqaB2TDhGiKUqj6IdnckVPyOOdrAJANU4_IKeNVJUHKDfl1lTDkeYgJtdP0Y5wmbxLFnE3OowkzjZbqmGLAdKDWxz29NT5qNx9oMtmkW0NdoHpwvk8m0L2bB_oV95jxp6O9ywazeU-3cZwwuRyP4i4Rw87FXcJp-HPv6Tyg924ZCw6MuhF3LuyekBOLPpunx_OM_Pj86Wp7Xlx--3Kx_XBZDCWwubA1WOy1URobU6_vQSFTtrHYWWslB9GICqoGeiulWCuXXdczWTHVYFdBeUZe_c2dUrxZTJ7b0WVtvMdg4pLbmtecVWW9whf34HVcUlh7a5kAybiqlFjV86NautH07ZTWedKh_ff5K3h5BJg1ertuQrv8360tgWCi_A17NZep</recordid><startdate>20021120</startdate><enddate>20021120</enddate><creator>HIRAISHI, Satoshi</creator><creator>HIROTA, Hamao</creator><creator>HORIGUCHI, Yasunori</creator><creator>TAKEDA, Nobuhiro</creator><creator>FUJINO, Nobuyuki</creator><creator>OGAWA, Natsuko</creator><creator>NAKAHATA, Yayoi</creator><general>Elsevier Science</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20021120</creationdate><title>Transthoracic Doppler assessment of coronary flow velocity reserve in children with Kawasaki disease: Comparison with coronary angiography and thallium-201 imaging</title><author>HIRAISHI, Satoshi ; HIROTA, Hamao ; HORIGUCHI, Yasunori ; TAKEDA, Nobuhiro ; FUJINO, Nobuyuki ; OGAWA, Natsuko ; NAKAHATA, Yayoi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h301t-f70fadce9ca8e720109a19f8fabfff62058540480df6650df26bbd164198ab403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Arteries - diagnostic imaging</topic><topic>Arteries - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity - physiology</topic><topic>Cardiology</topic><topic>Child</topic><topic>Child Welfare</topic><topic>Child, Preschool</topic><topic>Coronary Angiography</topic><topic>Coronary Artery Bypass</topic><topic>Coronary Stenosis - diagnosis</topic><topic>Coronary Stenosis - epidemiology</topic><topic>Coronary Stenosis - physiopathology</topic><topic>Coronary vessels</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Coronary Vessels - physiopathology</topic><topic>Echocardiography, Doppler - methods</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Hemodynamics - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical sciences</topic><topic>Mucocutaneous Lymph Node Syndrome - diagnosis</topic><topic>Mucocutaneous Lymph Node Syndrome - epidemiology</topic><topic>Mucocutaneous Lymph Node Syndrome - physiopathology</topic><topic>Observer Variation</topic><topic>Predictive Value of Tests</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Sensitivity and Specificity</topic><topic>Thallium Radioisotopes</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HIRAISHI, Satoshi</creatorcontrib><creatorcontrib>HIROTA, Hamao</creatorcontrib><creatorcontrib>HORIGUCHI, Yasunori</creatorcontrib><creatorcontrib>TAKEDA, Nobuhiro</creatorcontrib><creatorcontrib>FUJINO, Nobuyuki</creatorcontrib><creatorcontrib>OGAWA, Natsuko</creatorcontrib><creatorcontrib>NAKAHATA, Yayoi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HIRAISHI, Satoshi</au><au>HIROTA, Hamao</au><au>HORIGUCHI, Yasunori</au><au>TAKEDA, Nobuhiro</au><au>FUJINO, Nobuyuki</au><au>OGAWA, Natsuko</au><au>NAKAHATA, Yayoi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transthoracic Doppler assessment of coronary flow velocity reserve in children with Kawasaki disease: Comparison with coronary angiography and thallium-201 imaging</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2002-11-20</date><risdate>2002</risdate><volume>40</volume><issue>10</issue><spage>1816</spage><epage>1824</epage><pages>1816-1824</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>The purpose of this study was to determine the feasibility of coronary flow velocity reserve (CFVR) measurement by transthoracic Doppler echocardiography (TTDE) in children with Kawasaki disease (KD).
Doppler-derived CFVR is a reliable marker predicting the presence of myocardial ischemia.
We studied 49 patients (median age 11 years) with KD. The CFVR was calculated as the ratio of hyperemic to basal peak (peak CFVR) and mean (mean CFVR) diastolic flow velocities in the posterior descending coronary artery (PD) and left anterior descending coronary artery (LAD). The CFVR measurements by TTDE were compared with the results of coronary angiography, thallium-201 (Tl-201) single-photon emission computed tomography (SPECT), and intracoronary Doppler study.
The CFVR measurements by TTDE were obtained in 92 (94%) of 98 vessels of the PD and LAD in 49 study patients. Both peak and mean CFVRs for 21 stenotic vessels were significantly smaller than those for 35 normal vessels and for 20 vessels with aneurysmal lesions (p < 0.0001). Peak and mean CFVR <2.0 predicted significant coronary stenosis, as determined by coronary angiography, with sensitivities and specificities of 89% and 96% and 89% and 97%, respectively. Also, both peak and mean CFVRs were correlated with reversible perfusion defects on Tl-201 SPECT (agreement 80%; kappa 0.4). The correlation between peak and mean CFVRs determined by the TTDE and intracoronary Doppler studies in 36 vessels of 23 patients were 0.76 and 0.80, respectively.
The CFVR measured by TTDE predicts the presence of significant coronary stenosis of either the right coronary artery or LAD, as well as myocardial ischemia of these territories in children with KD.</abstract><cop>New York, NY</cop><pub>Elsevier Science</pub><pmid>12446066</pmid><doi>10.1016/S0735-1097(02)02479-8</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-1097 |
| ispartof | Journal of the American College of Cardiology, 2002-11, Vol.40 (10), p.1816-1824 |
| issn | 0735-1097 1558-3597 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72721437 |
| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Arteries - diagnostic imaging Arteries - physiopathology Biological and medical sciences Blood Flow Velocity - physiology Cardiology Child Child Welfare Child, Preschool Coronary Angiography Coronary Artery Bypass Coronary Stenosis - diagnosis Coronary Stenosis - epidemiology Coronary Stenosis - physiopathology Coronary vessels Coronary Vessels - diagnostic imaging Coronary Vessels - physiopathology Echocardiography, Doppler - methods Female Heart attacks Hemodynamics - physiology Humans Male Medical imaging Medical sciences Mucocutaneous Lymph Node Syndrome - diagnosis Mucocutaneous Lymph Node Syndrome - epidemiology Mucocutaneous Lymph Node Syndrome - physiopathology Observer Variation Predictive Value of Tests Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Sensitivity and Specificity Thallium Radioisotopes Tomography, Emission-Computed, Single-Photon |
| title | Transthoracic Doppler assessment of coronary flow velocity reserve in children with Kawasaki disease: Comparison with coronary angiography and thallium-201 imaging |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T20%3A54%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Transthoracic%20Doppler%20assessment%20of%20coronary%20flow%20velocity%20reserve%20in%20children%20with%20Kawasaki%20disease:%20Comparison%20with%20coronary%20angiography%20and%20thallium-201%20imaging&rft.jtitle=Journal%20of%20the%20American%20College%20of%20Cardiology&rft.au=HIRAISHI,%20Satoshi&rft.date=2002-11-20&rft.volume=40&rft.issue=10&rft.spage=1816&rft.epage=1824&rft.pages=1816-1824&rft.issn=0735-1097&rft.eissn=1558-3597&rft.coden=JACCDI&rft_id=info:doi/10.1016/S0735-1097(02)02479-8&rft_dat=%3Cproquest_pubme%3E3242355221%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1506129495&rft_id=info:pmid/12446066&rfr_iscdi=true |