Molecular epidemiology of tuberculosis in a low- to moderate-incidence state: are contact investigations enough?
To assess the circumstances of recent transmission of tuberculosis (TB) (progression to active disease
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| Veröffentlicht in: | Emerging infectious diseases 2002-11, Vol.8 (11), p.1271-1279 |
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| container_title | Emerging infectious diseases |
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| creator | Cronin, Wendy A Golub, Jonathan E Lathan, Monica J Mukasa, Leonard N Hooper, Nancy Razeq, Jafar H Baruch, Nancy G Mulcahy, Donna Benjamin, William H Magder, Laurence S Strickland, G Thomas Bishai, William R |
| description | To assess the circumstances of recent transmission of tuberculosis (TB) (progression to active disease |
| doi_str_mv | 10.3201/eid0811.020261 |
| format | Article |
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We also reviewed medical records and interviewed patients with genetically matching M. tuberculosis strains to identify epidemiologic links (cluster investigation). Traditional settings for transmission were defined as households or close relatives and friends; all other settings were considered nontraditional. Of 436 clustered patients, 115 had recently acquired TB. Cluster investigations were significantly more likely than contact investigations to identify patients who recently acquired TB in nontraditional settings (33/42 vs. 23/72, respectively; p<0.001). Transmission from a foreign-born person to a U.S.-born person was rare and occurred mainly in public settings. The time from symptom onset to diagnosis was twice as long for transmitters as for nontransmitters (16.8 vs. 8.5 weeks, respectively; p<0.01). Molecular epidemiologic studies showed that reducing diagnostic delays can prevent TB transmission in nontraditional settings, which elude contact investigations.</description><identifier>ISSN: 1080-6040</identifier><identifier>EISSN: 1080-6059</identifier><identifier>DOI: 10.3201/eid0811.020261</identifier><identifier>PMID: 12453355</identifier><language>eng</language><publisher>United States: U.S. National Center for Infectious Diseases</publisher><subject>Adolescent ; Adult ; Aged ; Carrier state (Communicable diseases) ; Child ; Child, Preschool ; Contact Tracing - methods ; DNA Fingerprinting ; DNA testing ; Female ; Genetic aspects ; Genotype ; Humans ; Incidence ; Infant ; Infection ; Male ; Maryland - epidemiology ; Middle Aged ; Molecular Epidemiology ; Mycobacterium tuberculosis - classification ; Mycobacterium tuberculosis - genetics ; Mycobacterium tuberculosis - isolation & purification ; Polymorphism, Restriction Fragment Length ; Risk Factors ; Socioeconomic Factors ; Time Factors ; Tuberculosis ; Tuberculosis - diagnosis ; Tuberculosis - epidemiology ; Tuberculosis - microbiology ; Tuberculosis - transmission</subject><ispartof>Emerging infectious diseases, 2002-11, Vol.8 (11), p.1271-1279</ispartof><rights>COPYRIGHT 2002 U.S. National Center for Infectious Diseases</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12453355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cronin, Wendy A</creatorcontrib><creatorcontrib>Golub, Jonathan E</creatorcontrib><creatorcontrib>Lathan, Monica J</creatorcontrib><creatorcontrib>Mukasa, Leonard N</creatorcontrib><creatorcontrib>Hooper, Nancy</creatorcontrib><creatorcontrib>Razeq, Jafar H</creatorcontrib><creatorcontrib>Baruch, Nancy G</creatorcontrib><creatorcontrib>Mulcahy, Donna</creatorcontrib><creatorcontrib>Benjamin, William H</creatorcontrib><creatorcontrib>Magder, Laurence S</creatorcontrib><creatorcontrib>Strickland, G Thomas</creatorcontrib><creatorcontrib>Bishai, William R</creatorcontrib><title>Molecular epidemiology of tuberculosis in a low- to moderate-incidence state: are contact investigations enough?</title><title>Emerging infectious diseases</title><addtitle>Emerg Infect Dis</addtitle><description>To assess the circumstances of recent transmission of tuberculosis (TB) (progression to active disease <2 years after infection), we obtained DNA fingerprints for 1172 (99%) of 1179 Mycobacterium tuberculosis isolates collected from Maryland TB patients from 1996 to 2000. We also reviewed medical records and interviewed patients with genetically matching M. tuberculosis strains to identify epidemiologic links (cluster investigation). Traditional settings for transmission were defined as households or close relatives and friends; all other settings were considered nontraditional. Of 436 clustered patients, 115 had recently acquired TB. Cluster investigations were significantly more likely than contact investigations to identify patients who recently acquired TB in nontraditional settings (33/42 vs. 23/72, respectively; p<0.001). Transmission from a foreign-born person to a U.S.-born person was rare and occurred mainly in public settings. The time from symptom onset to diagnosis was twice as long for transmitters as for nontransmitters (16.8 vs. 8.5 weeks, respectively; p<0.01). Molecular epidemiologic studies showed that reducing diagnostic delays can prevent TB transmission in nontraditional settings, which elude contact investigations.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Carrier state (Communicable diseases)</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Contact Tracing - methods</subject><subject>DNA Fingerprinting</subject><subject>DNA testing</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Genotype</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infection</subject><subject>Male</subject><subject>Maryland - epidemiology</subject><subject>Middle Aged</subject><subject>Molecular Epidemiology</subject><subject>Mycobacterium tuberculosis - classification</subject><subject>Mycobacterium tuberculosis - genetics</subject><subject>Mycobacterium tuberculosis - isolation & purification</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Risk Factors</subject><subject>Socioeconomic Factors</subject><subject>Time Factors</subject><subject>Tuberculosis</subject><subject>Tuberculosis - diagnosis</subject><subject>Tuberculosis - epidemiology</subject><subject>Tuberculosis - microbiology</subject><subject>Tuberculosis - transmission</subject><issn>1080-6040</issn><issn>1080-6059</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s9v1iAYB3BiNG5Orx4NF40HOx8olOLFLIvTJTNL_HVtKH3aF0PhtVB1__2Ym8Y3WaLhwI9-HgJfSshjBoc1B_YS3QAtY4fAgTfsDtln0ELVgNR3_4wF7JEHKX0FYKVE3yd7jAtZ11Luk-376NGu3iwUt27A2UUfpwsaR5rXHpfyKSaXqAvUUB9_VDRHOscBF5OxcsGWmmCRplzmr6hZkNoYsrG5lHzHlN1ksoshUQxxnTavH5J7o_EJH930B-TzyZtPx--qs_O3p8dHZ9UkQOdKtFALAeUitpVKMt5LrhsuOLLeYGMGJRXXtgWla94OskDR44BCK6UAx_qAPLved7vEb2s5SDe7ZNF7EzCuqVNccQYN-ydkbatEw3SBL67hZDx2LowxL8ZOGEoWPgYcXVk-0kLqmjFeeHULL-0qZHubf77jr2LEn3kya0rd6ccP_03Pv-zQp3_RDRqfNyn69deb7LgnNyms_YxDt13cbJaL7vefUl8CFfi88w</recordid><startdate>200211</startdate><enddate>200211</enddate><creator>Cronin, Wendy A</creator><creator>Golub, Jonathan E</creator><creator>Lathan, Monica J</creator><creator>Mukasa, Leonard N</creator><creator>Hooper, Nancy</creator><creator>Razeq, Jafar H</creator><creator>Baruch, Nancy G</creator><creator>Mulcahy, Donna</creator><creator>Benjamin, William H</creator><creator>Magder, Laurence S</creator><creator>Strickland, G Thomas</creator><creator>Bishai, William R</creator><general>U.S. National Center for Infectious Diseases</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>IOV</scope><scope>ISR</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200211</creationdate><title>Molecular epidemiology of tuberculosis in a low- to moderate-incidence state: are contact investigations enough?</title><author>Cronin, Wendy A ; Golub, Jonathan E ; Lathan, Monica J ; Mukasa, Leonard N ; Hooper, Nancy ; Razeq, Jafar H ; Baruch, Nancy G ; Mulcahy, Donna ; Benjamin, William H ; Magder, Laurence S ; Strickland, G Thomas ; Bishai, William R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g409t-4803440605c857512b5296242e1bae6ad75729c8079328d56054bede497770ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Carrier state (Communicable diseases)</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Contact Tracing - methods</topic><topic>DNA Fingerprinting</topic><topic>DNA testing</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Genotype</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Infection</topic><topic>Male</topic><topic>Maryland - epidemiology</topic><topic>Middle Aged</topic><topic>Molecular Epidemiology</topic><topic>Mycobacterium tuberculosis - classification</topic><topic>Mycobacterium tuberculosis - genetics</topic><topic>Mycobacterium tuberculosis - isolation & purification</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Risk Factors</topic><topic>Socioeconomic Factors</topic><topic>Time Factors</topic><topic>Tuberculosis</topic><topic>Tuberculosis - diagnosis</topic><topic>Tuberculosis - epidemiology</topic><topic>Tuberculosis - microbiology</topic><topic>Tuberculosis - transmission</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cronin, Wendy A</creatorcontrib><creatorcontrib>Golub, Jonathan E</creatorcontrib><creatorcontrib>Lathan, Monica J</creatorcontrib><creatorcontrib>Mukasa, Leonard N</creatorcontrib><creatorcontrib>Hooper, Nancy</creatorcontrib><creatorcontrib>Razeq, Jafar H</creatorcontrib><creatorcontrib>Baruch, Nancy G</creatorcontrib><creatorcontrib>Mulcahy, Donna</creatorcontrib><creatorcontrib>Benjamin, William H</creatorcontrib><creatorcontrib>Magder, Laurence S</creatorcontrib><creatorcontrib>Strickland, G Thomas</creatorcontrib><creatorcontrib>Bishai, William R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Emerging infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cronin, Wendy A</au><au>Golub, Jonathan E</au><au>Lathan, Monica J</au><au>Mukasa, Leonard N</au><au>Hooper, Nancy</au><au>Razeq, Jafar H</au><au>Baruch, Nancy G</au><au>Mulcahy, Donna</au><au>Benjamin, William H</au><au>Magder, Laurence S</au><au>Strickland, G Thomas</au><au>Bishai, William R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular epidemiology of tuberculosis in a low- to moderate-incidence state: are contact investigations enough?</atitle><jtitle>Emerging infectious diseases</jtitle><addtitle>Emerg Infect Dis</addtitle><date>2002-11</date><risdate>2002</risdate><volume>8</volume><issue>11</issue><spage>1271</spage><epage>1279</epage><pages>1271-1279</pages><issn>1080-6040</issn><eissn>1080-6059</eissn><abstract>To assess the circumstances of recent transmission of tuberculosis (TB) (progression to active disease <2 years after infection), we obtained DNA fingerprints for 1172 (99%) of 1179 Mycobacterium tuberculosis isolates collected from Maryland TB patients from 1996 to 2000. We also reviewed medical records and interviewed patients with genetically matching M. tuberculosis strains to identify epidemiologic links (cluster investigation). Traditional settings for transmission were defined as households or close relatives and friends; all other settings were considered nontraditional. Of 436 clustered patients, 115 had recently acquired TB. Cluster investigations were significantly more likely than contact investigations to identify patients who recently acquired TB in nontraditional settings (33/42 vs. 23/72, respectively; p<0.001). Transmission from a foreign-born person to a U.S.-born person was rare and occurred mainly in public settings. The time from symptom onset to diagnosis was twice as long for transmitters as for nontransmitters (16.8 vs. 8.5 weeks, respectively; p<0.01). 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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adolescent Adult Aged Carrier state (Communicable diseases) Child Child, Preschool Contact Tracing - methods DNA Fingerprinting DNA testing Female Genetic aspects Genotype Humans Incidence Infant Infection Male Maryland - epidemiology Middle Aged Molecular Epidemiology Mycobacterium tuberculosis - classification Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Polymorphism, Restriction Fragment Length Risk Factors Socioeconomic Factors Time Factors Tuberculosis Tuberculosis - diagnosis Tuberculosis - epidemiology Tuberculosis - microbiology Tuberculosis - transmission |
| title | Molecular epidemiology of tuberculosis in a low- to moderate-incidence state: are contact investigations enough? |
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