Purification, crystallization and preliminary X-ray analysis of the disintegrin contortrostatin from Agkistrodon contortrix contortrix snake venom

Disintegrins are cysteine‐rich RGD‐containing peptides that block tumor‐cell implantation and angiogenesis. Contortrostatin, a homodimeric disintegrin (64 residues in each chain) from southern copperhead snake venom, has been purified to homogeneity and crystallized. Initial attempts at crystallizat...

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Veröffentlicht in:	Acta crystallographica. Section D, Biological crystallography. Biological crystallography., 2002-12, Vol.58 (12), p.2122-2124
Hauptverfasser:	Moiseeva, Natalia, Swenson, Stephen D., Markland Jr, Francis S., Bau, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Chromatography, High Pressure Liquid contortrostatin Crotalid Venoms - chemistry Crystallography, X-Ray disintegrins Disintegrins - chemistry Disintegrins - isolation & purification Molecular Sequence Data Protein Conformation RGD proteins Sequence Homology, Amino Acid
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