Constitutive Activation and Endocytosis of the Complement Factor 5a Receptor: Evidence for Multiple Activated Conformations of a G Protein‐Coupled Receptor

Serpentine receptors relay hormonal or sensory stimuli to heterotrimeric guanine nucleotide‐binding proteins (G proteins). In most G protein‐coupled receptors (GPCRs), binding of the agonist ligand elicits both stimulation of the G protein and endocytosis of the receptor. We have begun to address wh...

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Veröffentlicht in:	Traffic (Copenhagen, Denmark) Denmark), 2002-12, Vol.3 (12), p.866-877
Hauptverfasser:	Whistler, Jennifer L., Gerber, Basil O., Meng, Elaine C., Baranski, Thomas J., Von Zastrow, Mark, Bourne, Henry R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - metabolism arrestin Arrestin - metabolism Biotin - pharmacology C5a Cell Line Cell Membrane - metabolism constitutive activation COS Cells Dose-Response Relationship, Drug Endocytosis Green Fluorescent Proteins GTP-Binding Proteins - metabolism Humans Ligands Luminescent Proteins - metabolism Microscopy, Fluorescence Models, Molecular Mutation Pertussis Toxin - pharmacology Phenotype Protein Binding Protein Conformation Protein Structure, Secondary Protein Structure, Tertiary Receptor, Anaphylatoxin C5a Receptors, Complement - metabolism Signal Transduction Time Factors Transfection
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