ADME evaluation: 2. A computer model for the prediction of intestinal absorption in humans

Purpose: To develop a computational method to rapidly evaluate human intestinal absorption, one of the drug properties included in the term ADME ( Absorption, Distribution, Metabolism, Excretion). Poor ADME properties are the most important reason for drug failure in clinical development. Methods: T...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmaceutical sciences 2002-12, Vol.17 (4), p.253-263
Hauptverfasser:	Klopman, Gilles, Stefan, Liliana R, Saiakhov, Roustem D
Format:	Artikel
Sprache:	eng
Schlagworte:	ADME Adsorption - drug effects Biological and medical sciences Biological Availability Computer Simulation - statistics & numerical data General pharmacology Human intestinal absorption Humans Intestinal Absorption - drug effects Intestinal Absorption - physiology Medical sciences Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Predictive Value of Tests QSAR model Quantitative Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!