Developmentally regulated expression of Neuro-p24 and its possible function in neurite extension
Process extension is a most marked and characteristic neuronal feature that is observed during the development, regeneration and plasticity of nervous system tissues. Neuro-p24, a novel membranous protein with a molecular weight of 24 kDa, is specifically localized in neurons, particularly in the ne...
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| Veröffentlicht in: | Neuroscience research 2002-12, Vol.44 (4), p.379-389 |
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| creator | Araki, Masasuke Nagata, Kizashi Satoh, Yumiko Kadota, Yoichi Hisha, Hiroko Adachi, Yasushi Taketani, Shigeru |
| description | Process extension is a most marked and characteristic neuronal feature that is observed during the development, regeneration and plasticity of nervous system tissues. Neuro-p24, a novel membranous protein with a molecular weight of 24 kDa, is specifically localized in neurons, particularly in the neurites. Based on its molecular structure and distribution pattern in the brain we proposed that Neuro-p24 plays a role in neurite extension. In the present study we have made several findings that support this hypothesis; first, Neuro-p24 was abundant in motor axonal fibers, neurites of dorsal root ganglia neurons and apical dendrites of cerebral cortex neurons when their extension or arborization was proceeding very actively. Secondly, when COS-7 epithelial cells were transfected with either wild-type or deletion-mutated
Neuro-p24 cDNAs, ectopic expression of wild-type cDNA caused morphological alterations resulting in a neuron-like appearance. These observations firmly support our proposal and indicate that Neuro-p24 plays an important role in the nervous tissue. |
| doi_str_mv | 10.1016/S0168-0102(02)00156-6 |
| format | Article |
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Neuro-p24 cDNAs, ectopic expression of wild-type cDNA caused morphological alterations resulting in a neuron-like appearance. These observations firmly support our proposal and indicate that Neuro-p24 plays an important role in the nervous tissue.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>cDNA transfection</subject><subject>Cell Differentiation - physiology</subject><subject>Cerebral cortex</subject><subject>Cerebral Cortex - cytology</subject><subject>Cerebral Cortex - growth & development</subject><subject>Cerebral Cortex - metabolism</subject><subject>COS Cells</subject><subject>DNA, Complementary - genetics</subject><subject>DRG neuron</subject><subject>Epithelial Cells - cytology</subject><subject>Epithelial Cells - metabolism</subject><subject>Ganglia, Spinal - cytology</subject><subject>Ganglia, Spinal - growth & development</subject><subject>Ganglia, Spinal - metabolism</subject><subject>Gene Expression Regulation, Developmental - physiology</subject><subject>Immunohistochemistry</subject><subject>Mice</subject><subject>Motor nerve axon</subject><subject>Mutation - genetics</subject><subject>Nerve Tissue Proteins - deficiency</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nervous System - cytology</subject><subject>Nervous System - growth & development</subject><subject>Nervous System - metabolism</subject><subject>Neurite extension</subject><subject>Neurites - metabolism</subject><subject>Neuro-p24</subject><subject>Neuromuscular Junction - cytology</subject><subject>Neuromuscular Junction - growth & development</subject><subject>Neuromuscular Junction - metabolism</subject><subject>Neuronal Plasticity - physiology</subject><subject>Pyramidal Cells - cytology</subject><subject>Pyramidal Cells - metabolism</subject><issn>0168-0102</issn><issn>1872-8111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PxCAQhonR6Lr6EzScjB6qDPTzZIzfidGD3rGFqcF0aQW60X8vdTd6NCFwmOdlZh5CDoCdAoP87DleZcKA8WPGTxiDLE_yDTKDsuBJCQCbZPaL7JBd798ZY6JKxTbZAZ6mWc7zGXm9wiV2_bBAG-qu-6IO38auDqgpfg4OvTe9pX1LH3F0fTLwlNZWUxM8HfpYbDqk7WhVmDBjqY2YCRjDAe2U3SNbbd153F-_c_Jyc_1yeZc8PN3eX148JCqFNCTQNKzSRYWtqqs4MWrIBNdCK1CqEC1nLI8EVIVKhSg1y1QtihJVKzhCJebkaPXt4PqPEX2QC-MVdl1tsR-9LHgBeVw_gtkKVC7O77CVgzOL2n1JYHIyK3_MykmbnM5kVuYxd7huMDYL1H-ptcoInK8AjFsuDTrplUGrUBuHKkjdm39afAOW24lX</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>Araki, Masasuke</creator><creator>Nagata, Kizashi</creator><creator>Satoh, Yumiko</creator><creator>Kadota, Yoichi</creator><creator>Hisha, Hiroko</creator><creator>Adachi, Yasushi</creator><creator>Taketani, Shigeru</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021201</creationdate><title>Developmentally regulated expression of Neuro-p24 and its possible function in neurite extension</title><author>Araki, Masasuke ; 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Neuro-p24, a novel membranous protein with a molecular weight of 24 kDa, is specifically localized in neurons, particularly in the neurites. Based on its molecular structure and distribution pattern in the brain we proposed that Neuro-p24 plays a role in neurite extension. In the present study we have made several findings that support this hypothesis; first, Neuro-p24 was abundant in motor axonal fibers, neurites of dorsal root ganglia neurons and apical dendrites of cerebral cortex neurons when their extension or arborization was proceeding very actively. Secondly, when COS-7 epithelial cells were transfected with either wild-type or deletion-mutated
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| subjects | Animals Animals, Newborn cDNA transfection Cell Differentiation - physiology Cerebral cortex Cerebral Cortex - cytology Cerebral Cortex - growth & development Cerebral Cortex - metabolism COS Cells DNA, Complementary - genetics DRG neuron Epithelial Cells - cytology Epithelial Cells - metabolism Ganglia, Spinal - cytology Ganglia, Spinal - growth & development Ganglia, Spinal - metabolism Gene Expression Regulation, Developmental - physiology Immunohistochemistry Mice Motor nerve axon Mutation - genetics Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - genetics Nervous System - cytology Nervous System - growth & development Nervous System - metabolism Neurite extension Neurites - metabolism Neuro-p24 Neuromuscular Junction - cytology Neuromuscular Junction - growth & development Neuromuscular Junction - metabolism Neuronal Plasticity - physiology Pyramidal Cells - cytology Pyramidal Cells - metabolism |
| title | Developmentally regulated expression of Neuro-p24 and its possible function in neurite extension |
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