Assay of plasma cannabidiol by capillary gas chromatography/ion trap mass spectroscopy following high-dose repeated daily oral administration in humans

Plasma levels of cannabidiol (CBD) were ascertained weekly in 14 Huntington's disease patients undergoing a double-blind, placebo-controlled, crossover trial of oral CBD (10 mg/kg/day=about 700 mg/day) for 6 weeks. The assay procedure involved trimethylsilyl (TMS) derivatization of CBD and the...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1991-11, Vol.40 (3), p.517-522
Hauptverfasser:	Consroe, Paul, Kennedy, Kurt, Schram, Karl
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Adult Aged Biological and medical sciences Cannabidiol (CBD) Cannabidiol - administration & dosage Cannabidiol - blood Cannabinoid Cannabis Capillary column GC Capsules of CBD and sesame oil Dronabinol - administration & dosage Dronabinol - analogs & derivatives Dronabinol - blood Drug addictions Female Gas Chromatography-Mass Spectrometry Gas chromatography/mass spectroscopy GC/MS Half-Life Half-life of CBD Humans Huntington Disease - metabolism Ion trap MS Male Marijuana Medical sciences Middle Aged Oral administration Pharmacokinetics of CBD Placebo Plasma delta-1-tetrahydrocannabinol Plasma delta-9-THC Plasma levels of CBD Sesame oil vehicle THC Toxicology
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