Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia

We examined isolated leukemia B cells of patients with chronic lymphocytic leukemia (CLL) for expression of zeta-associated protein 70 (ZAP-70). CLL B cells that have nonmutated immunoglobulin variable region genes (V genes) expressed levels of ZAP-70 protein that were comparable to those expressed...

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Veröffentlicht in:	Blood 2002-12, Vol.100 (13), p.4609-4614
Hauptverfasser:	Chen, Liguang, Widhopf, George, Huynh, Lang, Rassenti, Laura, Rai, Kanti R., Weiss, Arthur, Kipps, Thomas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy B-Lymphocytes - immunology B-Lymphocytes - metabolism Biological and medical sciences Bone marrow, stem cells transplantation. Graft versus host reaction Diseases in Twins Enzyme Precursors - metabolism Gene Expression Regulation, Leukemic Gene Rearrangement, B-Lymphocyte Genes, Immunoglobulin Hematologic and hematopoietic diseases Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin Variable Region - genetics Intracellular Signaling Peptides and Proteins Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Proteins - physiology Phosphorylation Protein Processing, Post-Translational Protein-Tyrosine Kinases - biosynthesis Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Protein-Tyrosine Kinases - physiology Receptors, Antigen, B-Cell - immunology Signal Transduction Syk Kinase Transfusions. Complications. Transfusion reactions. Cell and gene therapy ZAP-70 Protein-Tyrosine Kinase
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