Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive caucasians

Recent data suggest that MDR-1 expression may affect HIV-1 infectivity by modulating the immune response and its cellular permissiveness. We investigated whether three functional MDR-1 polymorphims (T-129C, G2677T/A, C3435T) were associated with the risk of infection in 137 Caucasians highly exposed...

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Veröffentlicht in:	AIDS (London) 2002-11, Vol.16 (17), p.2340-2342
Hauptverfasser:	IFERGAN, Igal, BERNARD, Nicole F, BRUNEAU, Julie, ALARY, Michel, TSOUKAS, Christos M, ROGER, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Biological and medical sciences Gene Frequency Genes, MDR Genetic Predisposition to Disease HIV Infections - genetics HIV-1 Human viral diseases Humans Infectious diseases Medical sciences Polymorphism, Genetic Prospective Studies Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
Online-Zugang:	Volltext
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