In vivo administration of vascular endothelial growth factor (VEGF) and its antagonist, soluble neuropilin-1, predicts a role of VEGF in the progression of acute myeloid leukemia in vivo

Recent findings implied that the progression of hematologic malignancies, like that of solid tumors, is dependent on neovascularization. Recent studies on patients with acute myeloid leukemia (AML) showed increased levels of leukocyte-associated vascular endothelial growth factor (VEGF) and neovascu...

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Veröffentlicht in:	Blood 2002-12, Vol.100 (13), p.4622-4628
Hauptverfasser:	Schuch, Gunter, Machluf, Marcelle, Bartsch, Georg, Nomi, Masashi, Richard, Henri, Atala, Anthony, Soker, Shay
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Antineoplastic agents Biological and medical sciences Chemotherapy Disease Progression Endothelial Growth Factors - antagonists & inhibitors Endothelial Growth Factors - biosynthesis Endothelial Growth Factors - genetics Endothelial Growth Factors - pharmacology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Gene Expression Regulation, Leukemic Genetic Therapy Hematologic and hematopoietic diseases Humans Intercellular Signaling Peptides and Proteins - biosynthesis Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - pharmacology Leukemia, Experimental - genetics Leukemia, Experimental - metabolism Leukemia, Experimental - pathology Leukemia, Experimental - therapy Leukemia, Myeloid - metabolism Leukemia, Myeloid - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphokines - antagonists & inhibitors Lymphokines - biosynthesis Lymphokines - genetics Lymphokines - pharmacology Medical sciences Mice Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Proteins - physiology Neovascularization, Pathologic - physiopathology Neuropilin-1 - genetics Neuropilin-1 - physiology Pharmacology. Drug treatments Phosphorylation Protein Processing, Post-Translational Recombinant Fusion Proteins - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Neoplasm - biosynthesis Solubility Swine Transfection Tumor Cells, Cultured - chemistry Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism U937 Cells - metabolism Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-2 - biosynthesis Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factors
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