Interleukin-10, Polymorphism in SLC11A1 (formerly NRAMP1), and Susceptibility to Tuberculosis

Host genetic factors are major determinants of susceptibility to tuberculosis, and an understanding of the molecular basis of this observation has major implications for the development of novel therapies and vaccines. Slc11a1 (formerly Nramp1), the first murine infection susceptibility locus identi...

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Veröffentlicht in:	The Journal of infectious diseases 2002-12, Vol.186 (12), p.1808-1814
Hauptverfasser:	Awomoyi, Agnes A., Marchant, Arnaud, Howson, Joanna M. M., McAdam, Keith P. W. J., Blackwell, Jenefer M., Newport, Melanie J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Bacterial diseases Biological and medical sciences Case-Control Studies Cation Transport Proteins - genetics Cytokines Gambia Genetic Predisposition to Disease Genotype Genotypes Human bacterial diseases Humans Immunity, Innate Infections Infectious diseases Interleukin-10 - biosynthesis Macrophages Major Article Male Medical genetics Medical sciences Mice Middle Aged Monocytes Monocytes - immunology Mycobacterium tuberculosis Polymorphism, Genetic Tuberculosis Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - blood Tuberculosis, Pulmonary - genetics Tuberculosis, Pulmonary - immunology
Online-Zugang:	Volltext
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