Rabeprazole improves health-related quality of life in patients with erosive gastroesophageal reflux disease

The purpose of this study was to assess the effect of rabeprazole 20 mg once a day on patient-reported health-related quality of life in routine clinical practice. Patients with erosive gastroesophageal reflux disease participating in an open-label, 8-week study completed the SF-36 Health Survey bef...

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Veröffentlicht in:Digestive diseases and sciences 2002-11, Vol.47 (11), p.2574-2578
Hauptverfasser: Johanson, John F, Siddique, Reshmi, Damiano, Anne M, Jokubaitis, Leonard, Murthy, Anita, Bhattacharjya, Ashoke
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container_end_page 2578
container_issue 11
container_start_page 2574
container_title Digestive diseases and sciences
container_volume 47
creator Johanson, John F
Siddique, Reshmi
Damiano, Anne M
Jokubaitis, Leonard
Murthy, Anita
Bhattacharjya, Ashoke
description The purpose of this study was to assess the effect of rabeprazole 20 mg once a day on patient-reported health-related quality of life in routine clinical practice. Patients with erosive gastroesophageal reflux disease participating in an open-label, 8-week study completed the SF-36 Health Survey before and after treatment with rabeprazole. For all SF-36 scales, there was a statistically significant (p < or = 0.007) improvement in mean scores from baseline to week 8. Improvements in each of the subscales, except for physical functioning, general health, and mental health, were at least 5% in magnitude, a level considered clinically meaningful. Furthermore, while baseline scores were significantly poorer than general United States population scores, follow-up scores for four of the subscales (role limitations due to physical problems, social functioning, role limitations due to emotional problems, and mental health) were comparable to general population scores. In conclusion, rabeprazole significantly improved health-related quality of life in erosive gastroesophageal reflux disease patients and restored social functioning and emotional well-being to levels comparable to those observed in the United States general population.
doi_str_mv 10.1023/A:1020532714664
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subjects 2-Pyridinylmethylsulfinylbenzimidazoles
Adolescent
Adult
Aged
Aged, 80 and over
Benzimidazoles - therapeutic use
Enzyme Inhibitors - therapeutic use
Female
Gastroesophageal Reflux - drug therapy
Health Status Indicators
Humans
Male
Middle Aged
Omeprazole - analogs & derivatives
Quality of Life
Rabeprazole
title Rabeprazole improves health-related quality of life in patients with erosive gastroesophageal reflux disease
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