Increased Expression and Activation of c-Jun Contributes to Human Amylin-induced Apoptosis in Pancreatic Islet β-Cells

The role of c-Jun in apoptosis evoked by human amylin was investigated using human and rat insulinoma β-cell lines. Two transient increases in the levels of c-jun mRNA were detected at 30 minutes and eight hours after treatment with human amylin. The level of c-Jun protein was also up-regulated in a...

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Veröffentlicht in:	Journal of molecular biology 2002-11, Vol.324 (2), p.271-285
Hauptverfasser:	Zhang, Shaoping, Liu, Junxi, MacGibbon, Geraldine, Dragunow, Michael, Cooper, Garth J.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid - pharmacology Animals AP-1 binding Apoptosis - drug effects Blotting, Northern Blotting, Western c-Jun Cell Division - drug effects DNA Primers - chemistry DNA, Antisense - pharmacology Electrophoretic Mobility Shift Assay human amylin Humans Immunoenzyme Techniques Insulinoma - metabolism Insulinoma - pathology Insulinoma - physiopathology Islet Amyloid Polypeptide Islets of Langerhans - drug effects Islets of Langerhans - metabolism Luciferases - metabolism Oligodeoxyribonucleotides, Antisense - pharmacology Phosphorylation Polymerase Chain Reaction Proto-Oncogene Proteins c-jun - antagonists & inhibitors Proto-Oncogene Proteins c-jun - metabolism Rats Transcription Factor AP-1 - metabolism Tumor Cells, Cultured - drug effects type-2 diabetes β-cell apoptosis
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