Myosin‐V, a Versatile Motor for Short‐Range Vesicle Transport
Myosin‐V is a versatile motor involved in short‐range transport of vesicles in the actin‐rich cortex of the cell. It binds to several different kinds of vesicles, and the mechanism by which it interacts with the vesicle surface is being unraveled, primarily in melanocytes. Members of the Rab family...
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| Veröffentlicht in: | Traffic (Copenhagen, Denmark) Denmark), 2002-12, Vol.3 (12), p.859-865 |
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| creator | Langford, George M. |
| description | Myosin‐V is a versatile motor involved in short‐range transport of vesicles in the actin‐rich cortex of the cell. It binds to several different kinds of vesicles, and the mechanism by which it interacts with the vesicle surface is being unraveled, primarily in melanocytes. Members of the Rab family of G‐proteins are required for the recruitment of myosin‐V to vesicles. Rab27a and its rabphilin‐like effector protein, Melanophilin, recruit myosin‐Va to melanosomes and appear to serve as the membrane receptor. Myosin‐V is also involved in fast axonal/dendritic transport and, interestingly, it forms a complex with kinesin, a microtubule‐based motor. This kinesin/myosin‐V heteromotor complex allows long‐range movement of vesicles within axons and dendrites on microtubules and short‐range movement in the dendritic spines and axon terminals on actin filaments. The direct interaction of motors from both filament systems may represent the mechanism by which the transition of vesicles from microtubules to actin filaments is regulated. |
| doi_str_mv | 10.1034/j.1600-0854.2002.31202.x |
| format | Article |
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It binds to several different kinds of vesicles, and the mechanism by which it interacts with the vesicle surface is being unraveled, primarily in melanocytes. Members of the Rab family of G‐proteins are required for the recruitment of myosin‐V to vesicles. Rab27a and its rabphilin‐like effector protein, Melanophilin, recruit myosin‐Va to melanosomes and appear to serve as the membrane receptor. Myosin‐V is also involved in fast axonal/dendritic transport and, interestingly, it forms a complex with kinesin, a microtubule‐based motor. This kinesin/myosin‐V heteromotor complex allows long‐range movement of vesicles within axons and dendrites on microtubules and short‐range movement in the dendritic spines and axon terminals on actin filaments. The direct interaction of motors from both filament systems may represent the mechanism by which the transition of vesicles from microtubules to actin filaments is regulated.</description><subject>actin filaments</subject><subject>Adaptor Proteins, Signal Transducing</subject><subject>Animals</subject><subject>Biological Transport</subject><subject>Carrier Proteins - chemistry</subject><subject>fast axonal transport</subject><subject>GTP-Binding Proteins - metabolism</subject><subject>Humans</subject><subject>kinesin</subject><subject>Kinesin - chemistry</subject><subject>Kinesin - metabolism</subject><subject>Models, Molecular</subject><subject>Myosin Type V - metabolism</subject><subject>Myosin Type V - physiology</subject><subject>myosin‐V</subject><subject>Neurons - metabolism</subject><subject>organelle transport</subject><subject>Protein Binding</subject><subject>rab G‐proteins</subject><subject>vesicle</subject><issn>1398-9219</issn><issn>1600-0854</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkN1KwzAYhoMobk5vQXrkka35-domJ8IQ_2BDmHOnIU1T7ejamXS4nXkJXqNXYroNPfUgyQvv832BB6GA4IhgBlfziCQYh5jHEFGMacQI9ff6APV_i0OfmeChoET00Ilzc-zJGOAY9QiFmBEQfTQcbxpX1t-fX7PLQAUzY51qy8oE46ZtbFD48_zW2NYDE1W_Gk-4Uvt-alXtlr45RUeFqpw5278D9HJ3O715CEdP9483w1GogSQ0TAA4QGxSmiVcJYZCngjBgXHCeco0UE2JYtpwlaeMA_eRCtAiyQqeQ8YG6GK3d2mb95VxrVyUTpuqUrVpVk6mNCUEEvAg34HaNs5ZU8ilLRfKbiTBstMn57KzJDtLstMnt_rk2o-e7_9YZQuT_w3ufXngegd8eEebfy-W08lwG9kPiiV-Fg</recordid><startdate>200212</startdate><enddate>200212</enddate><creator>Langford, George M.</creator><general>Munksgaard International Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200212</creationdate><title>Myosin‐V, a Versatile Motor for Short‐Range Vesicle Transport</title><author>Langford, George M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4162-6448445e72b68a6e24d699843818873c42c21a3ce8ad738483ce294c96bf8d4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>actin filaments</topic><topic>Adaptor Proteins, Signal Transducing</topic><topic>Animals</topic><topic>Biological Transport</topic><topic>Carrier Proteins - chemistry</topic><topic>fast axonal transport</topic><topic>GTP-Binding Proteins - metabolism</topic><topic>Humans</topic><topic>kinesin</topic><topic>Kinesin - chemistry</topic><topic>Kinesin - metabolism</topic><topic>Models, Molecular</topic><topic>Myosin Type V - metabolism</topic><topic>Myosin Type V - physiology</topic><topic>myosin‐V</topic><topic>Neurons - metabolism</topic><topic>organelle transport</topic><topic>Protein Binding</topic><topic>rab G‐proteins</topic><topic>vesicle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Langford, George M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Traffic (Copenhagen, Denmark)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Langford, George M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myosin‐V, a Versatile Motor for Short‐Range Vesicle Transport</atitle><jtitle>Traffic (Copenhagen, Denmark)</jtitle><addtitle>Traffic</addtitle><date>2002-12</date><risdate>2002</risdate><volume>3</volume><issue>12</issue><spage>859</spage><epage>865</epage><pages>859-865</pages><issn>1398-9219</issn><eissn>1600-0854</eissn><abstract>Myosin‐V is a versatile motor involved in short‐range transport of vesicles in the actin‐rich cortex of the cell. It binds to several different kinds of vesicles, and the mechanism by which it interacts with the vesicle surface is being unraveled, primarily in melanocytes. Members of the Rab family of G‐proteins are required for the recruitment of myosin‐V to vesicles. Rab27a and its rabphilin‐like effector protein, Melanophilin, recruit myosin‐Va to melanosomes and appear to serve as the membrane receptor. Myosin‐V is also involved in fast axonal/dendritic transport and, interestingly, it forms a complex with kinesin, a microtubule‐based motor. This kinesin/myosin‐V heteromotor complex allows long‐range movement of vesicles within axons and dendrites on microtubules and short‐range movement in the dendritic spines and axon terminals on actin filaments. 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| ispartof | Traffic (Copenhagen, Denmark), 2002-12, Vol.3 (12), p.859-865 |
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| language | eng |
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| source | MEDLINE; Wiley Journals; Wiley Free Content; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | actin filaments Adaptor Proteins, Signal Transducing Animals Biological Transport Carrier Proteins - chemistry fast axonal transport GTP-Binding Proteins - metabolism Humans kinesin Kinesin - chemistry Kinesin - metabolism Models, Molecular Myosin Type V - metabolism Myosin Type V - physiology myosin‐V Neurons - metabolism organelle transport Protein Binding rab G‐proteins vesicle |
| title | Myosin‐V, a Versatile Motor for Short‐Range Vesicle Transport |
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