Association between estrogen receptor gene polymorphisms and curve severity of idiopathic scoliosis
Analysis of the estrogen receptor gene of girls with idiopathic scoliosis. To determine whether estrogen receptor gene polymorphisms correlate with curve severity of adolescent idiopathic scoliosis. Studies suggest that idiopathic scoliosis is a familial condition and that curve progression is relat...
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| Veröffentlicht in: | Spine (Philadelphia, Pa. 1976) Pa. 1976), 2002-11, Vol.27 (21), p.2357-2362 |
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| creator | INOUE, Masatoshi MINAMI, Shohei MORIYA, Hideshige NAKATA, Yoshinori KITAHARA, Hiroshi OTSUKA, Yoshinori ISOBE, Keijiro TAKASO, Masashi TOKUNAGA, Makoto NISHIKAWA, Shinsuke MARUTA, Tetsuro |
| description | Analysis of the estrogen receptor gene of girls with idiopathic scoliosis.
To determine whether estrogen receptor gene polymorphisms correlate with curve severity of adolescent idiopathic scoliosis.
Studies suggest that idiopathic scoliosis is a familial condition and that curve progression is related to genetically determined factors, such as skeletal and sexual growth.
A total of 304 girls with idiopathic scoliosis were followed until growth maturation. Height, arm span, menarcheal age, and age at growth maturation were recorded, and curve severity was measured using Cobb's method. The estrogen receptor gene, which contains polymorphic PvuII and XbaI sites, was amplified from lymphocyte deoxyribonucleic acid by polymerase chain reaction.
The mean maximum Cobb measurements for patients with genotypes XX and Xx were greater than for those with genotype xx (P = 0.002). The risk of curve progression, defined as progression of >5 degrees from initial evaluation, was higher with genotype Xx than with xx (P = 0.03). Patients with genotypes XX and Xx had a significantly higher risk for operative treatment than those with genotype xx (21.4%, 24.7% vs. 7.6%, P< 0.001). Growth examination around the time of the growth spurt revealed that the XbaI site polymorphism was also related to the age of growth maturation. The frequency of patients with growth maturation at >or=16 years was higher for genotypes XX and Xx than for genotype xx (33.3%, 29.9% vs. 16.8%, P= 0.013).
Our results suggest that the XbaI site polymorphism is associated with curve severity. DNA analysis may predict curve progression. |
| doi_str_mv | 10.1097/00007632-200211010-00009 |
| format | Article |
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To determine whether estrogen receptor gene polymorphisms correlate with curve severity of adolescent idiopathic scoliosis.
Studies suggest that idiopathic scoliosis is a familial condition and that curve progression is related to genetically determined factors, such as skeletal and sexual growth.
A total of 304 girls with idiopathic scoliosis were followed until growth maturation. Height, arm span, menarcheal age, and age at growth maturation were recorded, and curve severity was measured using Cobb's method. The estrogen receptor gene, which contains polymorphic PvuII and XbaI sites, was amplified from lymphocyte deoxyribonucleic acid by polymerase chain reaction.
The mean maximum Cobb measurements for patients with genotypes XX and Xx were greater than for those with genotype xx (P = 0.002). The risk of curve progression, defined as progression of >5 degrees from initial evaluation, was higher with genotype Xx than with xx (P = 0.03). Patients with genotypes XX and Xx had a significantly higher risk for operative treatment than those with genotype xx (21.4%, 24.7% vs. 7.6%, P< 0.001). Growth examination around the time of the growth spurt revealed that the XbaI site polymorphism was also related to the age of growth maturation. The frequency of patients with growth maturation at >or=16 years was higher for genotypes XX and Xx than for genotype xx (33.3%, 29.9% vs. 16.8%, P= 0.013).
Our results suggest that the XbaI site polymorphism is associated with curve severity. DNA analysis may predict curve progression.</description><identifier>ISSN: 0362-2436</identifier><identifier>EISSN: 1528-1159</identifier><identifier>DOI: 10.1097/00007632-200211010-00009</identifier><identifier>PMID: 12438984</identifier><identifier>CODEN: SPINDD</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott</publisher><subject>Adolescent ; Biological and medical sciences ; Child ; Disease Progression ; Diseases of the osteoarticular system ; Diseases of the spine ; Female ; Follow-Up Studies ; Gene Frequency ; Genotype ; Humans ; Japan - epidemiology ; Medical sciences ; Menarche ; Polymorphism, Genetic ; Predictive Value of Tests ; Radiography ; Receptors, Estrogen - genetics ; Risk Factors ; Scoliosis - diagnostic imaging ; Scoliosis - epidemiology ; Scoliosis - genetics ; Scoliosis - surgery ; Severity of Illness Index ; Spine - diagnostic imaging ; Spine - growth & development ; Spine - surgery</subject><ispartof>Spine (Philadelphia, Pa. 1976), 2002-11, Vol.27 (21), p.2357-2362</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-178b9755c44ec668afa78ec3cd58f1e5ae28f465ac615e9381e61c2d34d0efd63</citedby><cites>FETCH-LOGICAL-c420t-178b9755c44ec668afa78ec3cd58f1e5ae28f465ac615e9381e61c2d34d0efd63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14004861$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12438984$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>INOUE, Masatoshi</creatorcontrib><creatorcontrib>MINAMI, Shohei</creatorcontrib><creatorcontrib>MORIYA, Hideshige</creatorcontrib><creatorcontrib>NAKATA, Yoshinori</creatorcontrib><creatorcontrib>KITAHARA, Hiroshi</creatorcontrib><creatorcontrib>OTSUKA, Yoshinori</creatorcontrib><creatorcontrib>ISOBE, Keijiro</creatorcontrib><creatorcontrib>TAKASO, Masashi</creatorcontrib><creatorcontrib>TOKUNAGA, Makoto</creatorcontrib><creatorcontrib>NISHIKAWA, Shinsuke</creatorcontrib><creatorcontrib>MARUTA, Tetsuro</creatorcontrib><title>Association between estrogen receptor gene polymorphisms and curve severity of idiopathic scoliosis</title><title>Spine (Philadelphia, Pa. 1976)</title><addtitle>Spine (Phila Pa 1976)</addtitle><description>Analysis of the estrogen receptor gene of girls with idiopathic scoliosis.
To determine whether estrogen receptor gene polymorphisms correlate with curve severity of adolescent idiopathic scoliosis.
Studies suggest that idiopathic scoliosis is a familial condition and that curve progression is related to genetically determined factors, such as skeletal and sexual growth.
A total of 304 girls with idiopathic scoliosis were followed until growth maturation. Height, arm span, menarcheal age, and age at growth maturation were recorded, and curve severity was measured using Cobb's method. The estrogen receptor gene, which contains polymorphic PvuII and XbaI sites, was amplified from lymphocyte deoxyribonucleic acid by polymerase chain reaction.
The mean maximum Cobb measurements for patients with genotypes XX and Xx were greater than for those with genotype xx (P = 0.002). The risk of curve progression, defined as progression of >5 degrees from initial evaluation, was higher with genotype Xx than with xx (P = 0.03). Patients with genotypes XX and Xx had a significantly higher risk for operative treatment than those with genotype xx (21.4%, 24.7% vs. 7.6%, P< 0.001). Growth examination around the time of the growth spurt revealed that the XbaI site polymorphism was also related to the age of growth maturation. The frequency of patients with growth maturation at >or=16 years was higher for genotypes XX and Xx than for genotype xx (33.3%, 29.9% vs. 16.8%, P= 0.013).
Our results suggest that the XbaI site polymorphism is associated with curve severity. DNA analysis may predict curve progression.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Disease Progression</subject><subject>Diseases of the osteoarticular system</subject><subject>Diseases of the spine</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Medical sciences</subject><subject>Menarche</subject><subject>Polymorphism, Genetic</subject><subject>Predictive Value of Tests</subject><subject>Radiography</subject><subject>Receptors, Estrogen - genetics</subject><subject>Risk Factors</subject><subject>Scoliosis - diagnostic imaging</subject><subject>Scoliosis - epidemiology</subject><subject>Scoliosis - genetics</subject><subject>Scoliosis - surgery</subject><subject>Severity of Illness Index</subject><subject>Spine - diagnostic imaging</subject><subject>Spine - growth & development</subject><subject>Spine - surgery</subject><issn>0362-2436</issn><issn>1528-1159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1vFDEMhiMEokvpX0C5wG0gTjKZ5FhVfEmVuNDzKOvxtEEzkyGeLdp_35Qu1Bfbrx7b8iuEBPURVOg-qRqdM7rRSmkABap5lMILsYNW-wagDS_FThlXEWvcmXjD_KsSzkB4Lc6gij54uxN4yZwxxS3lRe5p-0O0SOKt5NtaFEJat1xkbUiueTrOuax3iWeWcRkkHso9SaZ7Kmk7yjzKNKS8xu0uoWTMU8qc-K14NcaJ6eKUz8XNl88_r7411z--fr-6vG7QarU10Pl96NoWrSV0zscxdp7Q4ND6EaiNpP1oXRvRQUvBeCAHqAdjB0Xj4My5-PC0dy3596E-0c-JkaYpLpQP3He6U8EoXUH_BGLJzIXGfi1pjuXYg-ofDe7_Gdz_N_ivFOrou9ONw36m4Xnw5GgF3p-AyBinscQFEz9zVinrHZgH4iaFcg</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>INOUE, Masatoshi</creator><creator>MINAMI, Shohei</creator><creator>MORIYA, Hideshige</creator><creator>NAKATA, Yoshinori</creator><creator>KITAHARA, Hiroshi</creator><creator>OTSUKA, Yoshinori</creator><creator>ISOBE, Keijiro</creator><creator>TAKASO, Masashi</creator><creator>TOKUNAGA, Makoto</creator><creator>NISHIKAWA, Shinsuke</creator><creator>MARUTA, Tetsuro</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Association between estrogen receptor gene polymorphisms and curve severity of idiopathic scoliosis</title><author>INOUE, Masatoshi ; MINAMI, Shohei ; MORIYA, Hideshige ; NAKATA, Yoshinori ; KITAHARA, Hiroshi ; OTSUKA, Yoshinori ; ISOBE, Keijiro ; TAKASO, Masashi ; TOKUNAGA, Makoto ; NISHIKAWA, Shinsuke ; MARUTA, Tetsuro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-178b9755c44ec668afa78ec3cd58f1e5ae28f465ac615e9381e61c2d34d0efd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Disease Progression</topic><topic>Diseases of the osteoarticular system</topic><topic>Diseases of the spine</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Medical sciences</topic><topic>Menarche</topic><topic>Polymorphism, Genetic</topic><topic>Predictive Value of Tests</topic><topic>Radiography</topic><topic>Receptors, Estrogen - genetics</topic><topic>Risk Factors</topic><topic>Scoliosis - diagnostic imaging</topic><topic>Scoliosis - epidemiology</topic><topic>Scoliosis - genetics</topic><topic>Scoliosis - surgery</topic><topic>Severity of Illness Index</topic><topic>Spine - diagnostic imaging</topic><topic>Spine - growth & development</topic><topic>Spine - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>INOUE, Masatoshi</creatorcontrib><creatorcontrib>MINAMI, Shohei</creatorcontrib><creatorcontrib>MORIYA, Hideshige</creatorcontrib><creatorcontrib>NAKATA, Yoshinori</creatorcontrib><creatorcontrib>KITAHARA, Hiroshi</creatorcontrib><creatorcontrib>OTSUKA, Yoshinori</creatorcontrib><creatorcontrib>ISOBE, Keijiro</creatorcontrib><creatorcontrib>TAKASO, Masashi</creatorcontrib><creatorcontrib>TOKUNAGA, Makoto</creatorcontrib><creatorcontrib>NISHIKAWA, Shinsuke</creatorcontrib><creatorcontrib>MARUTA, Tetsuro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>INOUE, Masatoshi</au><au>MINAMI, Shohei</au><au>MORIYA, Hideshige</au><au>NAKATA, Yoshinori</au><au>KITAHARA, Hiroshi</au><au>OTSUKA, Yoshinori</au><au>ISOBE, Keijiro</au><au>TAKASO, Masashi</au><au>TOKUNAGA, Makoto</au><au>NISHIKAWA, Shinsuke</au><au>MARUTA, Tetsuro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between estrogen receptor gene polymorphisms and curve severity of idiopathic scoliosis</atitle><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle><addtitle>Spine (Phila Pa 1976)</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>27</volume><issue>21</issue><spage>2357</spage><epage>2362</epage><pages>2357-2362</pages><issn>0362-2436</issn><eissn>1528-1159</eissn><coden>SPINDD</coden><abstract>Analysis of the estrogen receptor gene of girls with idiopathic scoliosis.
To determine whether estrogen receptor gene polymorphisms correlate with curve severity of adolescent idiopathic scoliosis.
Studies suggest that idiopathic scoliosis is a familial condition and that curve progression is related to genetically determined factors, such as skeletal and sexual growth.
A total of 304 girls with idiopathic scoliosis were followed until growth maturation. Height, arm span, menarcheal age, and age at growth maturation were recorded, and curve severity was measured using Cobb's method. The estrogen receptor gene, which contains polymorphic PvuII and XbaI sites, was amplified from lymphocyte deoxyribonucleic acid by polymerase chain reaction.
The mean maximum Cobb measurements for patients with genotypes XX and Xx were greater than for those with genotype xx (P = 0.002). The risk of curve progression, defined as progression of >5 degrees from initial evaluation, was higher with genotype Xx than with xx (P = 0.03). Patients with genotypes XX and Xx had a significantly higher risk for operative treatment than those with genotype xx (21.4%, 24.7% vs. 7.6%, P< 0.001). Growth examination around the time of the growth spurt revealed that the XbaI site polymorphism was also related to the age of growth maturation. The frequency of patients with growth maturation at >or=16 years was higher for genotypes XX and Xx than for genotype xx (33.3%, 29.9% vs. 16.8%, P= 0.013).
Our results suggest that the XbaI site polymorphism is associated with curve severity. DNA analysis may predict curve progression.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>12438984</pmid><doi>10.1097/00007632-200211010-00009</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Spine (Philadelphia, Pa. 1976), 2002-11, Vol.27 (21), p.2357-2362 |
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| subjects | Adolescent Biological and medical sciences Child Disease Progression Diseases of the osteoarticular system Diseases of the spine Female Follow-Up Studies Gene Frequency Genotype Humans Japan - epidemiology Medical sciences Menarche Polymorphism, Genetic Predictive Value of Tests Radiography Receptors, Estrogen - genetics Risk Factors Scoliosis - diagnostic imaging Scoliosis - epidemiology Scoliosis - genetics Scoliosis - surgery Severity of Illness Index Spine - diagnostic imaging Spine - growth & development Spine - surgery |
| title | Association between estrogen receptor gene polymorphisms and curve severity of idiopathic scoliosis |
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