Construction and immunogenicity of recombinant Mycobacterium bovis BCG expressing GP5 and M protein of porcine reproductive respiratory syndrome virus

Mycobacterium bovis BCG was used to express a truncated form of GP5 (lacking the first 30 NH 2-terminal residues) and M protein of porcine reproductive and respiratory syndrome virus (PRRSV). The PRRSV proteins were expressed in BCG under control of the mycobacterial hsp60 gene promoter either in th...

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Veröffentlicht in:	Vaccine 2002-11, Vol.21 (1), p.21-29
Hauptverfasser:	Bastos, Reginaldo G, Dellagostin, Odir A, Barletta, Raúl G, Doster, Allan R, Nelson, Eric, Osorio, Fernando A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - immunology Biological and medical sciences Blotting, Western Cloning, Molecular double prime M protein Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology gamma -Interferon Gene Expression Genetic Vectors glycoprotein gp35 glycoprotein gp5 GP5 and M PRRSV protein HSP60 gene Mice Mice, Inbred BALB C Microbiology movement protein Mycobacterium bovis Mycobacterium bovis - genetics Peptides - chemical synthesis Peptides - chemistry Peptides - immunology Porcine respiratory and reproductive syndrome virus Porcine respiratory and reproductive syndrome virus - chemistry Porcine respiratory and reproductive syndrome virus - genetics Porcine respiratory and reproductive syndrome virus - isolation & purification PRRSV Recombinant BCG Recombinant Proteins - immunology Swine Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, DNA - immunology Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Viral Matrix Proteins - genetics Viral Matrix Proteins - immunology Virology
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