Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase Cε

Phospholipase C epsilon is a phosphoinositide-specific phospholipase C that selectively associates with Ras and Rap small GTPases as a target. Here we explored the molecular basis of the Rap1- as well as Ras-mediated regulation of phospholipase C epsilon upon platelet-derived growth factor stimulati...

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Veröffentlicht in:	Oncogene 2002-11, Vol.21 (53), p.8105-8113
Hauptverfasser:	SONG, Chunhua, SATOH, Takaya, EDAMATSU, Hironori, DONGMEI WU, TADANO, Makoto, XIANLONG GAO, KATAOKA, Tohru
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Apoptosis Apoptosis - drug effects Biological and medical sciences Cell Line - drug effects Cell Line - metabolism Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cercopithecus aethiops COS Cells Enzyme Activation - drug effects Fundamental and applied biological sciences. Psychology Genes, ras Growth factors Guanine Guanine nucleotide exchange factor Guanine Nucleotide Exchange Factors - metabolism Guanosine Triphosphate - metabolism Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Homology Humans Inositol 1,4,5-Trisphosphate - biosynthesis Interleukin-3 - pharmacology Molecular and cellular biology Mutants Phosphoinositide Phospholipase C Phospholipase C Platelet-derived growth factor Platelet-Derived Growth Factor - pharmacology Point Mutation Protein Binding Protein Structure, Tertiary Proto-Oncogene Proteins p21(ras) - chemistry Proto-Oncogene Proteins p21(ras) - physiology rap GTP-Binding Proteins - metabolism rap1 GTP-Binding Proteins - chemistry rap1 GTP-Binding Proteins - genetics rap1 GTP-Binding Proteins - physiology Rap1 protein Rats Receptors, Platelet-Derived Growth Factor - drug effects Receptors, Platelet-Derived Growth Factor - genetics Recombinant Fusion Proteins - physiology Sequence Deletion Signal Transduction - drug effects Structure-Activity Relationship Transfection Type C Phospholipases - chemistry Type C Phospholipases - metabolism
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