Prion protein (PrP) gene polymorphisms associated with natural scrapie cases and their flock-mates in Ireland
The PrP genotypes associated with natural scrapie in Ireland were determined and a comparison was made between genotypes found in scrapie-infected sheep and those found in healthy animals from scrapie-infected flocks. Seven PrP genotypes were identified in scrapie-infected animals: VV 136 RR 154 QQ...
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| Veröffentlicht in: | Research in veterinary science 2002-12, Vol.73 (3), p.243-250 |
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| creator | O’Doherty, E Healy, A Aherne, M Hanrahan, J.P Weavers, E Doherty, M Roche, J.F Gunn, M Sweeney, T |
| description | The PrP genotypes associated with natural scrapie in Ireland were determined and a comparison was made between genotypes found in scrapie-infected sheep and those found in healthy animals from scrapie-infected flocks. Seven PrP genotypes were identified in scrapie-infected animals:
VV
136
RR
154
QQ
171,
VA
136
RR
154
QQ
171,
VA
136
RR
154
QR
171,
VA
136
RR
154
QH
171,
AA
136
RR
154
QQ
171,
AA
136
RR
154
QH
171
and AA
136RR
154HH
171. Of 11 scrapie-infected flocks, 15 genotypes were identified in the healthy flock-mates. The genotypes identified in scrapie-affected animals were also all identified in healthy flock-mates. In 9 of the 11 flocks studied, the genotype frequencies among scrapie-infected animals were significantly different from those among healthy flock-mates. The results show that there is a significant risk of developing the clinical signs of scrapie associated with particular PrP genotypes in the Irish sheep population. The association between the V
136R
154Q
171 allele and scrapie was evident, as was the association between A
136R
154R
171 and resistance to developing the clinical signs of scrapie. The presence of the A
136H
154Q
171 allele in the flocks examined resulted in a decreased risk of developing scrapie compared to the presence of the A
136R
154Q
171. |
| doi_str_mv | 10.1016/S0034-5288(02)00073-5 |
| format | Article |
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VV
136
RR
154
QQ
171,
VA
136
RR
154
QQ
171,
VA
136
RR
154
QR
171,
VA
136
RR
154
QH
171,
AA
136
RR
154
QQ
171,
AA
136
RR
154
QH
171
and AA
136RR
154HH
171. Of 11 scrapie-infected flocks, 15 genotypes were identified in the healthy flock-mates. The genotypes identified in scrapie-affected animals were also all identified in healthy flock-mates. In 9 of the 11 flocks studied, the genotype frequencies among scrapie-infected animals were significantly different from those among healthy flock-mates. The results show that there is a significant risk of developing the clinical signs of scrapie associated with particular PrP genotypes in the Irish sheep population. The association between the V
136R
154Q
171 allele and scrapie was evident, as was the association between A
136R
154R
171 and resistance to developing the clinical signs of scrapie. The presence of the A
136H
154Q
171 allele in the flocks examined resulted in a decreased risk of developing scrapie compared to the presence of the A
136R
154Q
171.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/S0034-5288(02)00073-5</identifier><identifier>PMID: 12443681</identifier><language>eng</language><publisher>England: Elsevier India Pvt Ltd</publisher><subject>Alleles ; Animals ; DNA - chemistry ; DNA - genetics ; Female ; Ireland ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Prions - classification ; Prions - genetics ; Scrapie - genetics ; Sheep ; Statistics, Nonparametric</subject><ispartof>Research in veterinary science, 2002-12, Vol.73 (3), p.243-250</ispartof><rights>2002 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-4d5ba9440036276e5dd13502d3b70e1a2fc0499bc3f990a2914c1fe6edcbb90e3</citedby><cites>FETCH-LOGICAL-c361t-4d5ba9440036276e5dd13502d3b70e1a2fc0499bc3f990a2914c1fe6edcbb90e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0034528802000735$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12443681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O’Doherty, E</creatorcontrib><creatorcontrib>Healy, A</creatorcontrib><creatorcontrib>Aherne, M</creatorcontrib><creatorcontrib>Hanrahan, J.P</creatorcontrib><creatorcontrib>Weavers, E</creatorcontrib><creatorcontrib>Doherty, M</creatorcontrib><creatorcontrib>Roche, J.F</creatorcontrib><creatorcontrib>Gunn, M</creatorcontrib><creatorcontrib>Sweeney, T</creatorcontrib><title>Prion protein (PrP) gene polymorphisms associated with natural scrapie cases and their flock-mates in Ireland</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>The PrP genotypes associated with natural scrapie in Ireland were determined and a comparison was made between genotypes found in scrapie-infected sheep and those found in healthy animals from scrapie-infected flocks. Seven PrP genotypes were identified in scrapie-infected animals:
VV
136
RR
154
QQ
171,
VA
136
RR
154
QQ
171,
VA
136
RR
154
QR
171,
VA
136
RR
154
QH
171,
AA
136
RR
154
QQ
171,
AA
136
RR
154
QH
171
and AA
136RR
154HH
171. Of 11 scrapie-infected flocks, 15 genotypes were identified in the healthy flock-mates. The genotypes identified in scrapie-affected animals were also all identified in healthy flock-mates. In 9 of the 11 flocks studied, the genotype frequencies among scrapie-infected animals were significantly different from those among healthy flock-mates. The results show that there is a significant risk of developing the clinical signs of scrapie associated with particular PrP genotypes in the Irish sheep population. The association between the V
136R
154Q
171 allele and scrapie was evident, as was the association between A
136R
154R
171 and resistance to developing the clinical signs of scrapie. The presence of the A
136H
154Q
171 allele in the flocks examined resulted in a decreased risk of developing scrapie compared to the presence of the A
136R
154Q
171.</description><subject>Alleles</subject><subject>Animals</subject><subject>DNA - chemistry</subject><subject>DNA - genetics</subject><subject>Female</subject><subject>Ireland</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Prions - classification</subject><subject>Prions - genetics</subject><subject>Scrapie - genetics</subject><subject>Sheep</subject><subject>Statistics, Nonparametric</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlOwzAQhi0EomV5BJBPiB4CXpPmhBBiqVSJSsDZcuwJNSRxsFMQb4-hFRw5zWG-f5YPoSNKziih-fkDIVxkkk2np4RNCCEFz-QWGlPJWcbynG6j8S8yQnsxviRIUFrsohFlQvB8SseoXQTnO9wHP4Dr8OkiLCb4GTrAvW8-Wx_6pYttxDpGb5wewOIPNyxxp4dV0A2OJujeATY6QqI6i4cluIDrxpvXrE2BiNPcWYAmNQ_QTq2bCIebuo-ebq4fr-6y-f3t7Opynhme0yETVla6FCLdn7MiB2kt5ZIwy6uCANWsNkSUZWV4XZZEs5IKQ2vIwZqqKgnwfXSynpv-eltBHFTrooEm3QB-FVXBClLIaZlAuQZN8DEGqFUfXKvDp6JEfXtWP57Vt0RFmPrxrGTKHW8WrKoW7F9qIzYBF2sA0pvvDoKKxkFnwLoAZlDWu39WfAFtdo3m</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>O’Doherty, E</creator><creator>Healy, A</creator><creator>Aherne, M</creator><creator>Hanrahan, J.P</creator><creator>Weavers, E</creator><creator>Doherty, M</creator><creator>Roche, J.F</creator><creator>Gunn, M</creator><creator>Sweeney, T</creator><general>Elsevier India Pvt Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021201</creationdate><title>Prion protein (PrP) gene polymorphisms associated with natural scrapie cases and their flock-mates in Ireland</title><author>O’Doherty, E ; Healy, A ; Aherne, M ; Hanrahan, J.P ; Weavers, E ; Doherty, M ; Roche, J.F ; Gunn, M ; Sweeney, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-4d5ba9440036276e5dd13502d3b70e1a2fc0499bc3f990a2914c1fe6edcbb90e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Alleles</topic><topic>Animals</topic><topic>DNA - chemistry</topic><topic>DNA - genetics</topic><topic>Female</topic><topic>Ireland</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Prions - classification</topic><topic>Prions - genetics</topic><topic>Scrapie - genetics</topic><topic>Sheep</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O’Doherty, E</creatorcontrib><creatorcontrib>Healy, A</creatorcontrib><creatorcontrib>Aherne, M</creatorcontrib><creatorcontrib>Hanrahan, J.P</creatorcontrib><creatorcontrib>Weavers, E</creatorcontrib><creatorcontrib>Doherty, M</creatorcontrib><creatorcontrib>Roche, J.F</creatorcontrib><creatorcontrib>Gunn, M</creatorcontrib><creatorcontrib>Sweeney, T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O’Doherty, E</au><au>Healy, A</au><au>Aherne, M</au><au>Hanrahan, J.P</au><au>Weavers, E</au><au>Doherty, M</au><au>Roche, J.F</au><au>Gunn, M</au><au>Sweeney, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prion protein (PrP) gene polymorphisms associated with natural scrapie cases and their flock-mates in Ireland</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>2002-12-01</date><risdate>2002</risdate><volume>73</volume><issue>3</issue><spage>243</spage><epage>250</epage><pages>243-250</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>The PrP genotypes associated with natural scrapie in Ireland were determined and a comparison was made between genotypes found in scrapie-infected sheep and those found in healthy animals from scrapie-infected flocks. Seven PrP genotypes were identified in scrapie-infected animals:
VV
136
RR
154
QQ
171,
VA
136
RR
154
QQ
171,
VA
136
RR
154
QR
171,
VA
136
RR
154
QH
171,
AA
136
RR
154
QQ
171,
AA
136
RR
154
QH
171
and AA
136RR
154HH
171. Of 11 scrapie-infected flocks, 15 genotypes were identified in the healthy flock-mates. The genotypes identified in scrapie-affected animals were also all identified in healthy flock-mates. In 9 of the 11 flocks studied, the genotype frequencies among scrapie-infected animals were significantly different from those among healthy flock-mates. The results show that there is a significant risk of developing the clinical signs of scrapie associated with particular PrP genotypes in the Irish sheep population. The association between the V
136R
154Q
171 allele and scrapie was evident, as was the association between A
136R
154R
171 and resistance to developing the clinical signs of scrapie. The presence of the A
136H
154Q
171 allele in the flocks examined resulted in a decreased risk of developing scrapie compared to the presence of the A
136R
154Q
171.</abstract><cop>England</cop><pub>Elsevier India Pvt Ltd</pub><pmid>12443681</pmid><doi>10.1016/S0034-5288(02)00073-5</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0034-5288 |
| ispartof | Research in veterinary science, 2002-12, Vol.73 (3), p.243-250 |
| issn | 0034-5288 1532-2661 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72707589 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alleles Animals DNA - chemistry DNA - genetics Female Ireland Polymorphism, Genetic Polymorphism, Restriction Fragment Length Prions - classification Prions - genetics Scrapie - genetics Sheep Statistics, Nonparametric |
| title | Prion protein (PrP) gene polymorphisms associated with natural scrapie cases and their flock-mates in Ireland |
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