Highly unsaturated fatty acid induced tumour regression in glioma pharmacodynamics and bioavailability of gamma linolenic acid in an implantation glioma model: effects on tumour biomass, apoptosis and neuronal tissue histology
Highly unsaturated fatty acids (HUFAs) are naturally occurring anti-tumour agents. HUFAs act as intracellular signalling molecules in cell proliferation and death. In human glioma, HUFAs may stimulate tumour regression and apoptosis. An implantation glioma model, using the C6 glioma cell line, was u...
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| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2002-11, Vol.67 (5), p.283-292 |
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| creator | Leaver, H.A. Wharton, S.B. Bell, H.S. Leaver-Yap, I.M.M. Whittle, I.R. |
| description | Highly unsaturated fatty acids (HUFAs) are naturally occurring anti-tumour agents. HUFAs act as intracellular signalling molecules in cell proliferation and death. In human glioma, HUFAs may stimulate tumour regression and apoptosis. An implantation glioma model, using the C6 glioma cell line, was used to investigate the bioactivity of locally infused n-6 HUFA gamma linolenic acid (GLA). Rat brains (15 normal and 37 C6 tumour bearing) were infused with vehicle or GLA 200 μM–2 mM. The most active local concentration of GLA for anti-tumour activity was 2 mM, infused at 1 μ l/h over 7 days. Tumour regression, increased apoptosis and decreased proliferation were observed in tumours of rats infused with this concentration of GLA. Little effect on normal neuronal tissue was detected. The intraparenchymal route was an effective method of GLA administration in the treatment of glioma. These studies provide further insights into the potential role of HUFAs as anti-glioma agents. |
| doi_str_mv | 10.1054/plef.2002.0431 |
| format | Article |
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HUFAs act as intracellular signalling molecules in cell proliferation and death. In human glioma, HUFAs may stimulate tumour regression and apoptosis. An implantation glioma model, using the C6 glioma cell line, was used to investigate the bioactivity of locally infused n-6 HUFA gamma linolenic acid (GLA). Rat brains (15 normal and 37 C6 tumour bearing) were infused with vehicle or GLA 200 μM–2 mM. The most active local concentration of GLA for anti-tumour activity was 2 mM, infused at 1 μ l/h over 7 days. Tumour regression, increased apoptosis and decreased proliferation were observed in tumours of rats infused with this concentration of GLA. Little effect on normal neuronal tissue was detected. The intraparenchymal route was an effective method of GLA administration in the treatment of glioma. 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HUFAs act as intracellular signalling molecules in cell proliferation and death. In human glioma, HUFAs may stimulate tumour regression and apoptosis. An implantation glioma model, using the C6 glioma cell line, was used to investigate the bioactivity of locally infused n-6 HUFA gamma linolenic acid (GLA). Rat brains (15 normal and 37 C6 tumour bearing) were infused with vehicle or GLA 200 μM–2 mM. The most active local concentration of GLA for anti-tumour activity was 2 mM, infused at 1 μ l/h over 7 days. Tumour regression, increased apoptosis and decreased proliferation were observed in tumours of rats infused with this concentration of GLA. Little effect on normal neuronal tissue was detected. The intraparenchymal route was an effective method of GLA administration in the treatment of glioma. These studies provide further insights into the potential role of HUFAs as anti-glioma agents.</description><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Brain - drug effects</subject><subject>Brain - pathology</subject><subject>Brain Neoplasms - drug therapy</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - pathology</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Cell Division - drug effects</subject><subject>Disease Models, Animal</subject><subject>Fatty Acids, Unsaturated - pharmacology</subject><subject>Foods and miscellaneous</subject><subject>gamma-Linolenic Acid - metabolism</subject><subject>Glioma - drug therapy</subject><subject>Glioma - metabolism</subject><subject>Glioma - pathology</subject><subject>In Situ Nick-End Labeling</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Signal Transduction</subject><subject>Tumors</subject><issn>0952-3278</issn><issn>1532-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhiMEotvClSPyBU7sYsf5Wm6oAopUiUvv0cQfu4McO3icSvm7_BIcbVBPlQ-WPI_fGfspineCHwSvq8-TM_ZQcl4eeCXFi2Inalnuy66UL4sdP9blXpZtd1VcE_3mGROiel1cibKq6qprd8XfOzyd3cJmT5DmCMloZiGlhYFCzdDrWeWjNI9hjiyaUzREGHyusJPDMAKbzhBHUEEvHkZUxMBrNmCAR0AHAzrMacGyE4yZduiDMx7V_wYZZzhODnyCtCZvsWPQxn1hxlqjErFc2IYY1jLRJwZTmFIgvHT0Zo7Bg2MJiWbDzkgpuHBa3hSvLDgyb7f9pnj4_u3h9m5__-vHz9uv93slW572yupGqlbblrc1aNMpOYhaVbU52lprXQkhZHPMkG4GOTRaDtCUegAruNBS3hQfL7FTDH9mQ6kfkZRx-WEmzNS3ZcubLCSDhwuoYiCKxvZTxBHi0gver1L7VWq_Su1XqfnC-y15Hkajn_DNYgY-bACQAmcjeIX0xFU8r45nrrtwJn_DI5rYk0Ljs2CM-ZN7HfC5Gf4BGL7GDQ</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>Leaver, H.A.</creator><creator>Wharton, S.B.</creator><creator>Bell, H.S.</creator><creator>Leaver-Yap, I.M.M.</creator><creator>Whittle, I.R.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Highly unsaturated fatty acid induced tumour regression in glioma pharmacodynamics and bioavailability of gamma linolenic acid in an implantation glioma model: effects on tumour biomass, apoptosis and neuronal tissue histology</title><author>Leaver, H.A. ; Wharton, S.B. ; Bell, H.S. ; Leaver-Yap, I.M.M. ; Whittle, I.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-cfd63c7df7075ade8c3b15c45e9f5ddd4111369d63d6b3b6d3ba62dbaf101d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Apoptosis - drug effects</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Brain - drug effects</topic><topic>Brain - pathology</topic><topic>Brain Neoplasms - drug therapy</topic><topic>Brain Neoplasms - metabolism</topic><topic>Brain Neoplasms - pathology</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Cell Division - drug effects</topic><topic>Disease Models, Animal</topic><topic>Fatty Acids, Unsaturated - pharmacology</topic><topic>Foods and miscellaneous</topic><topic>gamma-Linolenic Acid - metabolism</topic><topic>Glioma - drug therapy</topic><topic>Glioma - metabolism</topic><topic>Glioma - pathology</topic><topic>In Situ Nick-End Labeling</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Signal Transduction</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leaver, H.A.</creatorcontrib><creatorcontrib>Wharton, S.B.</creatorcontrib><creatorcontrib>Bell, H.S.</creatorcontrib><creatorcontrib>Leaver-Yap, I.M.M.</creatorcontrib><creatorcontrib>Whittle, I.R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leaver, H.A.</au><au>Wharton, S.B.</au><au>Bell, H.S.</au><au>Leaver-Yap, I.M.M.</au><au>Whittle, I.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Highly unsaturated fatty acid induced tumour regression in glioma pharmacodynamics and bioavailability of gamma linolenic acid in an implantation glioma model: effects on tumour biomass, apoptosis and neuronal tissue histology</atitle><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>67</volume><issue>5</issue><spage>283</spage><epage>292</epage><pages>283-292</pages><issn>0952-3278</issn><eissn>1532-2823</eissn><abstract>Highly unsaturated fatty acids (HUFAs) are naturally occurring anti-tumour agents. HUFAs act as intracellular signalling molecules in cell proliferation and death. In human glioma, HUFAs may stimulate tumour regression and apoptosis. An implantation glioma model, using the C6 glioma cell line, was used to investigate the bioactivity of locally infused n-6 HUFA gamma linolenic acid (GLA). Rat brains (15 normal and 37 C6 tumour bearing) were infused with vehicle or GLA 200 μM–2 mM. The most active local concentration of GLA for anti-tumour activity was 2 mM, infused at 1 μ l/h over 7 days. Tumour regression, increased apoptosis and decreased proliferation were observed in tumours of rats infused with this concentration of GLA. Little effect on normal neuronal tissue was detected. The intraparenchymal route was an effective method of GLA administration in the treatment of glioma. 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| subjects | Animals Apoptosis - drug effects Biological and medical sciences Biological Availability Brain - drug effects Brain - pathology Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Brain Neoplasms - pathology Carcinogenesis, carcinogens and anticarcinogens Cell Division - drug effects Disease Models, Animal Fatty Acids, Unsaturated - pharmacology Foods and miscellaneous gamma-Linolenic Acid - metabolism Glioma - drug therapy Glioma - metabolism Glioma - pathology In Situ Nick-End Labeling Male Medical sciences Rats Rats, Wistar Signal Transduction Tumors |
| title | Highly unsaturated fatty acid induced tumour regression in glioma pharmacodynamics and bioavailability of gamma linolenic acid in an implantation glioma model: effects on tumour biomass, apoptosis and neuronal tissue histology |
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