Preparation and in vivo evaluation of an N-(p-[125I]iodophenethyl)maleimide-antibody conjugate

Protein sulfhydryl reactive N-(4-[125I]iodophenethyl)maleimide (IPEM, 5) was obtained from N-[4-(tri-n-butylstannyl)phenethyl]maleimide in 59-100% radiochemical yield. Conjugation of 5 to NR-ML-05 Fab, a murine anti-melanoma antibody Fab fragment that had been previously reduced with dithiothreitol...

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Veröffentlicht in:	Bioconjugate chemistry 1991-11, Vol.2 (6), p.435-440
Hauptverfasser:	Hylarides, Mark D, Wilbur, D. Scott, Reed, Michael W, Hadley, Stephen W, Schroeder, Joan R, Grant, Leah M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - immunology Dithiothreitol Female Immunoglobulin Fab Fragments Iodine Radioisotopes Iodobenzenes - chemical synthesis Iodobenzenes - chemistry Iodobenzenes - pharmacokinetics Isotope Labeling - methods Maleimides - chemical synthesis Maleimides - chemistry Maleimides - pharmacokinetics Melanoma - immunology Melanoma, Experimental - metabolism Mice Mice, Nude Stomach - metabolism Thyroid Gland - metabolism Tissue Distribution
Online-Zugang:	Volltext
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