Effects of the calcineurin dependent signaling pathway inhibition by cyclosporin A on early and late cardiac remodeling following myocardial infarction
Background: The calcineurin‐mediated signaling pathway has been implicated as one of the crucial pathways in cardiac hypertrophy. However, the role of calcineurin pathway on cardiac remodeling after myocardial infarction (MI) has not been well defined. Methods: Infarcted rats (n=45) were randomized...
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| Veröffentlicht in: | European journal of heart failure 2002-12, Vol.4 (6), p.713-718 |
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| container_title | European journal of heart failure |
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| creator | Youn, Tae-jin Piao, Hainan Kwon, Jin-sook Choi, So-young Kim, Hyung-sam Park, Dae-gyun Kim, Dong-woon Kim, Young-gyu Cho, Myeong-chan |
| description | Background:
The calcineurin‐mediated signaling pathway has been implicated as one of the crucial pathways in cardiac hypertrophy. However, the role of calcineurin pathway on cardiac remodeling after myocardial infarction (MI) has not been well defined.
Methods:
Infarcted rats (n=45) were randomized into calcineurin inhibitor, cyclosporin A (CsA) or vehicle groups, 3 days after MI and treated for 2 weeks (early post‐MI cardiac remodeling stage), or randomized 17 days after MI and treated for 2 weeks (late remodeling stage).
Results:
Calcineurin pathway inhibition during the early cardiac remodeling stage attenuated the myocardial hypertrophy after MI (P |
| doi_str_mv | 10.1016/S1388-9842(02)00120-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72706400</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72706400</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3984-a58bee3a565f36c99767c5998c0c42a0e3ad73cca08621e74db21c4744552f933</originalsourceid><addsrcrecordid>eNqNkd1u1DAQhSMEoqXwCCBfIbgI-C9xcoNUrXa7lAqQ-Lu0HGfSNTh2sLPa5kn6ujjNQm-RLHk0c843sk-WPSf4DcGkfPuFsKrK64rTV5i-xphQnPMH2SmpRJ3jivOHqf4rOcmexPgziQTG9HF2QigvWMHJaXa77jrQY0S-Q-MOkFZWGwf7YBxqYQDXghtRNNdOWeOu0aDG3UFNyLidacxovEPNhPSkrY-Dn13nKPVABTsh5Vpk1ThTQ2uURgF638IdqPPW-sNc9ZNf5jZROxX0TH2aPeqUjfDseJ9l3zbrr6ttfvXp4v3q_CrXLD0sV0XVADBVlEXHSl3XohS6qOtKY82pwmnUCqa1wlVJCQjeNpRoLjgvCtrVjJ1lLxfuEPzvPcRR9iZqsFY58PsoBRW45BgnYbEIdfAxBujkEEyvwiQJlnMi8i4ROX-3xOnMiUiefC-OC_ZND-296xhBErxbBAdjYfo_qlxfbjf3G_IFYOIIN_8AKvySpWCikD8-Xshtufm8qj98l5fsDzKuqxQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72706400</pqid></control><display><type>article</type><title>Effects of the calcineurin dependent signaling pathway inhibition by cyclosporin A on early and late cardiac remodeling following myocardial infarction</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><source>Wiley Online Library All Journals</source><creator>Youn, Tae-jin ; Piao, Hainan ; Kwon, Jin-sook ; Choi, So-young ; Kim, Hyung-sam ; Park, Dae-gyun ; Kim, Dong-woon ; Kim, Young-gyu ; Cho, Myeong-chan</creator><creatorcontrib>Youn, Tae-jin ; Piao, Hainan ; Kwon, Jin-sook ; Choi, So-young ; Kim, Hyung-sam ; Park, Dae-gyun ; Kim, Dong-woon ; Kim, Young-gyu ; Cho, Myeong-chan</creatorcontrib><description>Background:
The calcineurin‐mediated signaling pathway has been implicated as one of the crucial pathways in cardiac hypertrophy. However, the role of calcineurin pathway on cardiac remodeling after myocardial infarction (MI) has not been well defined.
Methods:
Infarcted rats (n=45) were randomized into calcineurin inhibitor, cyclosporin A (CsA) or vehicle groups, 3 days after MI and treated for 2 weeks (early post‐MI cardiac remodeling stage), or randomized 17 days after MI and treated for 2 weeks (late remodeling stage).
Results:
Calcineurin pathway inhibition during the early cardiac remodeling stage attenuated the myocardial hypertrophy after MI (P<0.05). However, left ventricular dimensions were further increased and fractional shortening deteriorated with calcineurin inhibition during this stage (P<0.05, each). During late remodeling stage, CsA treatment did not affect myocardial hypertrophy and cardiac dilation following MI.
Conclusion:
Our results strongly support the hypothesis that calcineurin pathway mediates compensatory myocardial hypertrophy during the early remodeling stage after MI. However, the calcineurin pathway does not seem to affect the late remodeling after MI.</description><identifier>ISSN: 1388-9842</identifier><identifier>EISSN: 1879-0844</identifier><identifier>DOI: 10.1016/S1388-9842(02)00120-4</identifier><identifier>PMID: 12453541</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Animals ; calcineurin ; Calcineurin - pharmacology ; Calcineurin Inhibitors ; Cyclosporine - pharmacology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Echocardiography ; Enzyme Inhibitors - pharmacology ; heart failure ; Heart Function Tests ; Hemodynamics - physiology ; hypertrophy ; Hypertrophy, Left Ventricular - prevention & control ; infarction ; Male ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - drug therapy ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Recovery of Function ; Reference Values ; remodeling ; Signal Transduction ; Time Factors ; Treatment Outcome ; Ventricular Remodeling</subject><ispartof>European journal of heart failure, 2002-12, Vol.4 (6), p.713-718</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © 2002 the Authors</rights><rights>Copyright 2002 European Society of Cardiology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3984-a58bee3a565f36c99767c5998c0c42a0e3ad73cca08621e74db21c4744552f933</citedby><cites>FETCH-LOGICAL-c3984-a58bee3a565f36c99767c5998c0c42a0e3ad73cca08621e74db21c4744552f933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2FS1388-9842%2802%2900120-4$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2FS1388-9842%2802%2900120-4$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12453541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Youn, Tae-jin</creatorcontrib><creatorcontrib>Piao, Hainan</creatorcontrib><creatorcontrib>Kwon, Jin-sook</creatorcontrib><creatorcontrib>Choi, So-young</creatorcontrib><creatorcontrib>Kim, Hyung-sam</creatorcontrib><creatorcontrib>Park, Dae-gyun</creatorcontrib><creatorcontrib>Kim, Dong-woon</creatorcontrib><creatorcontrib>Kim, Young-gyu</creatorcontrib><creatorcontrib>Cho, Myeong-chan</creatorcontrib><title>Effects of the calcineurin dependent signaling pathway inhibition by cyclosporin A on early and late cardiac remodeling following myocardial infarction</title><title>European journal of heart failure</title><addtitle>European Journal of Heart Failure</addtitle><description>Background:
The calcineurin‐mediated signaling pathway has been implicated as one of the crucial pathways in cardiac hypertrophy. However, the role of calcineurin pathway on cardiac remodeling after myocardial infarction (MI) has not been well defined.
Methods:
Infarcted rats (n=45) were randomized into calcineurin inhibitor, cyclosporin A (CsA) or vehicle groups, 3 days after MI and treated for 2 weeks (early post‐MI cardiac remodeling stage), or randomized 17 days after MI and treated for 2 weeks (late remodeling stage).
Results:
Calcineurin pathway inhibition during the early cardiac remodeling stage attenuated the myocardial hypertrophy after MI (P<0.05). However, left ventricular dimensions were further increased and fractional shortening deteriorated with calcineurin inhibition during this stage (P<0.05, each). During late remodeling stage, CsA treatment did not affect myocardial hypertrophy and cardiac dilation following MI.
Conclusion:
Our results strongly support the hypothesis that calcineurin pathway mediates compensatory myocardial hypertrophy during the early remodeling stage after MI. However, the calcineurin pathway does not seem to affect the late remodeling after MI.</description><subject>Animals</subject><subject>calcineurin</subject><subject>Calcineurin - pharmacology</subject><subject>Calcineurin Inhibitors</subject><subject>Cyclosporine - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Echocardiography</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>heart failure</subject><subject>Heart Function Tests</subject><subject>Hemodynamics - physiology</subject><subject>hypertrophy</subject><subject>Hypertrophy, Left Ventricular - prevention & control</subject><subject>infarction</subject><subject>Male</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Recovery of Function</subject><subject>Reference Values</subject><subject>remodeling</subject><subject>Signal Transduction</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Ventricular Remodeling</subject><issn>1388-9842</issn><issn>1879-0844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkd1u1DAQhSMEoqXwCCBfIbgI-C9xcoNUrXa7lAqQ-Lu0HGfSNTh2sLPa5kn6ujjNQm-RLHk0c843sk-WPSf4DcGkfPuFsKrK64rTV5i-xphQnPMH2SmpRJ3jivOHqf4rOcmexPgziQTG9HF2QigvWMHJaXa77jrQY0S-Q-MOkFZWGwf7YBxqYQDXghtRNNdOWeOu0aDG3UFNyLidacxovEPNhPSkrY-Dn13nKPVABTsh5Vpk1ThTQ2uURgF638IdqPPW-sNc9ZNf5jZROxX0TH2aPeqUjfDseJ9l3zbrr6ttfvXp4v3q_CrXLD0sV0XVADBVlEXHSl3XohS6qOtKY82pwmnUCqa1wlVJCQjeNpRoLjgvCtrVjJ1lLxfuEPzvPcRR9iZqsFY58PsoBRW45BgnYbEIdfAxBujkEEyvwiQJlnMi8i4ROX-3xOnMiUiefC-OC_ZND-296xhBErxbBAdjYfo_qlxfbjf3G_IFYOIIN_8AKvySpWCikD8-Xshtufm8qj98l5fsDzKuqxQ</recordid><startdate>200212</startdate><enddate>200212</enddate><creator>Youn, Tae-jin</creator><creator>Piao, Hainan</creator><creator>Kwon, Jin-sook</creator><creator>Choi, So-young</creator><creator>Kim, Hyung-sam</creator><creator>Park, Dae-gyun</creator><creator>Kim, Dong-woon</creator><creator>Kim, Young-gyu</creator><creator>Cho, Myeong-chan</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200212</creationdate><title>Effects of the calcineurin dependent signaling pathway inhibition by cyclosporin A on early and late cardiac remodeling following myocardial infarction</title><author>Youn, Tae-jin ; Piao, Hainan ; Kwon, Jin-sook ; Choi, So-young ; Kim, Hyung-sam ; Park, Dae-gyun ; Kim, Dong-woon ; Kim, Young-gyu ; Cho, Myeong-chan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3984-a58bee3a565f36c99767c5998c0c42a0e3ad73cca08621e74db21c4744552f933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>calcineurin</topic><topic>Calcineurin - pharmacology</topic><topic>Calcineurin Inhibitors</topic><topic>Cyclosporine - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Schedule</topic><topic>Echocardiography</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>heart failure</topic><topic>Heart Function Tests</topic><topic>Hemodynamics - physiology</topic><topic>hypertrophy</topic><topic>Hypertrophy, Left Ventricular - prevention & control</topic><topic>infarction</topic><topic>Male</topic><topic>Myocardial Infarction - diagnostic imaging</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Recovery of Function</topic><topic>Reference Values</topic><topic>remodeling</topic><topic>Signal Transduction</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Ventricular Remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Youn, Tae-jin</creatorcontrib><creatorcontrib>Piao, Hainan</creatorcontrib><creatorcontrib>Kwon, Jin-sook</creatorcontrib><creatorcontrib>Choi, So-young</creatorcontrib><creatorcontrib>Kim, Hyung-sam</creatorcontrib><creatorcontrib>Park, Dae-gyun</creatorcontrib><creatorcontrib>Kim, Dong-woon</creatorcontrib><creatorcontrib>Kim, Young-gyu</creatorcontrib><creatorcontrib>Cho, Myeong-chan</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of heart failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Youn, Tae-jin</au><au>Piao, Hainan</au><au>Kwon, Jin-sook</au><au>Choi, So-young</au><au>Kim, Hyung-sam</au><au>Park, Dae-gyun</au><au>Kim, Dong-woon</au><au>Kim, Young-gyu</au><au>Cho, Myeong-chan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of the calcineurin dependent signaling pathway inhibition by cyclosporin A on early and late cardiac remodeling following myocardial infarction</atitle><jtitle>European journal of heart failure</jtitle><addtitle>European Journal of Heart Failure</addtitle><date>2002-12</date><risdate>2002</risdate><volume>4</volume><issue>6</issue><spage>713</spage><epage>718</epage><pages>713-718</pages><issn>1388-9842</issn><eissn>1879-0844</eissn><abstract>Background:
The calcineurin‐mediated signaling pathway has been implicated as one of the crucial pathways in cardiac hypertrophy. However, the role of calcineurin pathway on cardiac remodeling after myocardial infarction (MI) has not been well defined.
Methods:
Infarcted rats (n=45) were randomized into calcineurin inhibitor, cyclosporin A (CsA) or vehicle groups, 3 days after MI and treated for 2 weeks (early post‐MI cardiac remodeling stage), or randomized 17 days after MI and treated for 2 weeks (late remodeling stage).
Results:
Calcineurin pathway inhibition during the early cardiac remodeling stage attenuated the myocardial hypertrophy after MI (P<0.05). However, left ventricular dimensions were further increased and fractional shortening deteriorated with calcineurin inhibition during this stage (P<0.05, each). During late remodeling stage, CsA treatment did not affect myocardial hypertrophy and cardiac dilation following MI.
Conclusion:
Our results strongly support the hypothesis that calcineurin pathway mediates compensatory myocardial hypertrophy during the early remodeling stage after MI. However, the calcineurin pathway does not seem to affect the late remodeling after MI.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>12453541</pmid><doi>10.1016/S1388-9842(02)00120-4</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals calcineurin Calcineurin - pharmacology Calcineurin Inhibitors Cyclosporine - pharmacology Disease Models, Animal Dose-Response Relationship, Drug Drug Administration Schedule Echocardiography Enzyme Inhibitors - pharmacology heart failure Heart Function Tests Hemodynamics - physiology hypertrophy Hypertrophy, Left Ventricular - prevention & control infarction Male Myocardial Infarction - diagnostic imaging Myocardial Infarction - drug therapy Random Allocation Rats Rats, Sprague-Dawley Recovery of Function Reference Values remodeling Signal Transduction Time Factors Treatment Outcome Ventricular Remodeling |
| title | Effects of the calcineurin dependent signaling pathway inhibition by cyclosporin A on early and late cardiac remodeling following myocardial infarction |
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