Chronic intrauterine and fetal infection with Gardnerella vaginalis

Objective: We sought to develop a model of chronic intrauterine and fetal infection with Gardnerella vaginalis.Study Design: The uterine horns of pregnant New Zealand White rabbits were inoculated on day 21 of gestation with either 107 colony-forming units (cfu) of G vaginalis or saline solution. At...

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Veröffentlicht in:	American journal of obstetrics and gynecology 2002-11, Vol.187 (5), p.1263-1266
Hauptverfasser:	McDuffie, Robert S., Kunze, Mirjam, Barr, Jane, Wolf, Douglas, Sze, Chun-I., Shikes, Robert, Sherman, Michael, Gibbs, Ronald S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amniotic Fluid - metabolism Amniotic Fluid - microbiology animal model Animals Bacterial diseases Bacterial diseases of the genital system Bacterial Infections - complications Bacterial Infections - metabolism Bacterial Infections - pathology Biological and medical sciences Brain - embryology Brain - microbiology Brain - pathology Chronic Disease Diseases of mother, fetus and pregnancy Female Fetal Diseases - metabolism Fetal Diseases - microbiology Fetal Diseases - pathology fetus Fetus - microbiology Fetus - pathology Gardnerella vaginalis Gardnerella vaginalis - isolation & purification Gynecology. Andrology. Obstetrics Human bacterial diseases Infectious diseases intrauterine infection Medical sciences Osmolar Concentration Pregnancy Pregnancy. Fetus. Placenta Rabbits tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism Uterine Diseases - metabolism Uterine Diseases - microbiology Uterus - microbiology
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Beschreibung
Zusammenfassung:	Objective: We sought to develop a model of chronic intrauterine and fetal infection with Gardnerella vaginalis.Study Design: The uterine horns of pregnant New Zealand White rabbits were inoculated on day 21 of gestation with either 107 colony-forming units (cfu) of G vaginalis or saline solution. At necropsy, cultures were taken from blood, uterus, amniotic fluid, and fetal tissues. Amniotic fluid was assayed for tumor necrosis factor (TNF)-α by bioassay. Maternal and fetal tissue samples were evaluated using the histologic index score. A P value
ISSN:	0002-9378 1097-6868
DOI:	10.1067/mob.2002.127129