Pharmacokinetic behavior of [57Co]Bleomycin liposomes in mice: comparison with the unencapsulated substance

The distribution and excretion of [Co]Bleomycin, dissolved in saline or encapsulated in liposomes, was studied in normal or tumor-bearing [P388 leukemia, reticulum cell sarcoma (RS)] mice. The free substance is cleared relatively quickly from the organism both after intravenous and intraperitoneal a...

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Veröffentlicht in:	Anti-cancer drugs 1991-12, Vol.2 (6), p.555-564
Hauptverfasser:	Fichtner, Iduna, Arndt, Dieter, Reszka, Regina, Gens, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bleomycin - administration & dosage Bleomycin - blood Bleomycin - pharmacology Cobalt Drug Carriers Female Leukemia P388 - drug therapy Leukemia P388 - metabolism Liposomes Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - metabolism Mice Mice, Inbred C57BL Mice, Inbred DBA Tissue Distribution
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