Both cell surface and internalized β-adrenoceptors are reduced in the failing myocardium

To study myocardial β-adrenoceptor internalization in heart failure, we measured β-adrenoceptor density in the particulate, light vesicle and supernatant fractions of ventricular tissue of dogs with experimental right ventricular failure and sham-operated dogs. Tissue was fractionated by centrifugat...

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Veröffentlicht in:	European journal of pharmacology 1991-11, Vol.205 (2), p.165-169
Hauptverfasser:	Sullebarger, J.Thompson, Fan, Tai-Hwang M., Torres, Fernando, Liang, Chang-seng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta -adrenergic Binding Sites Biological and medical sciences Cardiology. Vascular system Cardiomyopathy Cell Membrane - metabolism Congestive heart failure correlation density Dogs Heart heart diseases Heart Failure - metabolism Heart failure, cardiogenic pulmonary edema, cardiac enlargement Iodocyanopindolol Medical sciences Na +,K +-ATPase Norepinephrine Ouabain - metabolism Pindolol - analogs & derivatives Pindolol - metabolism receptors Receptors, Adrenergic, beta - metabolism reduction Sodium-Potassium-Exchanging ATPase - metabolism β-Adrenoceptors
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