Mood stabilizers in Alzheimer’s disease: symptomatic and neuroprotective rationales

Objective: This paper provides a case study of ‘reverse translational research’, in which empirical clinical trials focused on relieving psychopathological symptoms of Alzheimer’s disease (AD) ultimately led to mechanism-based trials addressing aspects of the underlying pathophysiology of Alzheimer’...

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Veröffentlicht in:	Advanced drug delivery reviews 2002-12, Vol.54 (12), p.1567-1577
Hauptverfasser:	Tariot, Pierre N, Loy, Rebekah, Ryan, J.Michael, Porsteinsson, Anton, Ismail, Saleem
Format:	Artikel
Sprache:	eng
Schlagworte:	Agitation Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer Disease - psychology Animals Apoptosis Clinical Trials as Topic - methods Dementia Humans Lithium Mood Disorders - drug therapy Mood Disorders - metabolism Mood Disorders - psychology Neuroprotective Agents - therapeutic use Psychomotor Agitation - drug therapy Psychomotor Agitation - metabolism Psychomotor Agitation - psychology Psychopathology Psychotropic Drugs - therapeutic use Valproate Valproic Acid - therapeutic use
Online-Zugang:	Volltext
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