Assessment of type I error rates for the statistical sub-model in NONMEM

The aim of this study was to assess the type I error rate when applying the likelihood ratio (LR) test, for components of the statistical sub-model in NONMEM. Data were simulated from a pharmacokinetic one compartment intravenous bolus model. Two models were fitted to the data, the simulation model...

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Veröffentlicht in:	Journal of pharmacokinetics and pharmacodynamics 2002-06, Vol.29 (3), p.251-269
Hauptverfasser:	WÄHLBY, Ulrika, BOUW, M. Rene, JONSSON, E. Niclas, KARLSSON, Mats O
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Biological and medical sciences Computer Simulation - statistics & numerical data General pharmacology Humans Injections, Intravenous - statistics & numerical data Likelihood Functions Medical sciences Models, Statistical Nonlinear Dynamics Normal distribution Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Studies
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