Hepatitis C virus replication in ‘autoimmune’ chronic hepatitis
Both high and low anti-hepatitis C virus antibody (anti-HCV) prevalence has been reported in autoimmune chronic active hepatitis. Therefore, we studied 15 consecutive HBsAg-negative, ELISA anti-HCV-positive, autoantibody-positive patients with biopsy proven chronic active hepatitis in order to confi...
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| Veröffentlicht in: | Journal of hepatology 1991-11, Vol.13 (3), p.364-367 |
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| creator | Magrin, Silvio Craxi, Antonio Fabiano, Carmelo Fiorentino, Germana Almasio, Piero Palazzo, Ugo Pinzello, Giovambattista Provenzano, Giuseppe Pagliaro, Luigi Choo, Qui-Lim Kuo, George Polito, Alan Han, Jang Houghton, Michael |
| description | Both high and low anti-hepatitis C virus antibody (anti-HCV) prevalence has been reported in autoimmune chronic active hepatitis. Therefore, we studied 15 consecutive HBsAg-negative, ELISA anti-HCV-positive, autoantibody-positive patients with biopsy proven chronic active hepatitis in order to confirm ELISA specificity by immunoblot test (RIBA-HCV), and to evaluate HCV replication by serum HCV-RNA. Nine patients were anti-nuclear, three type 1 anti-liver-kidney microsomal and three anti-smooth muscle antibody positive. None had associated autoimmune disease. All cases showed mild clinical disease and only moderate necroinflammatory activity. Response to prednisone was poor. RIBA-HCV confirmed ELISA results in all patients. HCV-RNA was found in the serum from 10 patients. Institution of α-interferon treatment in three steroid non-responsive patients was followed by prompt normalization of transaminases. Thus, a subgroup of autoantibody-positive chronic active hepatitis can be recognized as HCV-related and should be clinically and etiologically distinguished from autoimmune chronic active hepatitis. Trials of α-interferon treatment are worthwhile in this condition. |
| doi_str_mv | 10.1016/0168-8278(91)90082-M |
| format | Article |
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Therefore, we studied 15 consecutive HBsAg-negative, ELISA anti-HCV-positive, autoantibody-positive patients with biopsy proven chronic active hepatitis in order to confirm ELISA specificity by immunoblot test (RIBA-HCV), and to evaluate HCV replication by serum HCV-RNA. Nine patients were anti-nuclear, three type 1 anti-liver-kidney microsomal and three anti-smooth muscle antibody positive. None had associated autoimmune disease. All cases showed mild clinical disease and only moderate necroinflammatory activity. Response to prednisone was poor. RIBA-HCV confirmed ELISA results in all patients. HCV-RNA was found in the serum from 10 patients. Institution of α-interferon treatment in three steroid non-responsive patients was followed by prompt normalization of transaminases. Thus, a subgroup of autoantibody-positive chronic active hepatitis can be recognized as HCV-related and should be clinically and etiologically distinguished from autoimmune chronic active hepatitis. Trials of α-interferon treatment are worthwhile in this condition.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/0168-8278(91)90082-M</identifier><identifier>PMID: 1725529</identifier><identifier>CODEN: JOHEEC</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Autoantibodies - analysis ; Base Sequence ; Biological and medical sciences ; Enzyme-Linked Immunosorbent Assay ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepacivirus - genetics ; Hepacivirus - isolation & purification ; Hepacivirus - physiology ; Hepatitis - immunology ; Hepatitis - microbiology ; Hepatitis - pathology ; Hepatitis Antibodies - analysis ; Hepatitis C - diagnosis ; Hepatitis C - immunology ; Hepatitis C Antibodies ; Humans ; Liver - pathology ; Male ; Medical sciences ; Middle Aged ; Molecular Sequence Data ; Oligodeoxyribonucleotides ; Polymerase Chain Reaction ; RNA, Viral - genetics ; RNA, Viral - isolation & purification ; Virus Replication</subject><ispartof>Journal of hepatology, 1991-11, Vol.13 (3), p.364-367</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-bb52f7d84fcfa70fbb086d0a96808c42a7b7da4a7ded246cde412db71947edf03</citedby><cites>FETCH-LOGICAL-c386t-bb52f7d84fcfa70fbb086d0a96808c42a7b7da4a7ded246cde412db71947edf03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0168-8278(91)90082-M$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5129718$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1725529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Magrin, Silvio</creatorcontrib><creatorcontrib>Craxi, Antonio</creatorcontrib><creatorcontrib>Fabiano, Carmelo</creatorcontrib><creatorcontrib>Fiorentino, Germana</creatorcontrib><creatorcontrib>Almasio, Piero</creatorcontrib><creatorcontrib>Palazzo, Ugo</creatorcontrib><creatorcontrib>Pinzello, Giovambattista</creatorcontrib><creatorcontrib>Provenzano, Giuseppe</creatorcontrib><creatorcontrib>Pagliaro, Luigi</creatorcontrib><creatorcontrib>Choo, Qui-Lim</creatorcontrib><creatorcontrib>Kuo, George</creatorcontrib><creatorcontrib>Polito, Alan</creatorcontrib><creatorcontrib>Han, Jang</creatorcontrib><creatorcontrib>Houghton, Michael</creatorcontrib><title>Hepatitis C virus replication in ‘autoimmune’ chronic hepatitis</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>Both high and low anti-hepatitis C virus antibody (anti-HCV) prevalence has been reported in autoimmune chronic active hepatitis. Therefore, we studied 15 consecutive HBsAg-negative, ELISA anti-HCV-positive, autoantibody-positive patients with biopsy proven chronic active hepatitis in order to confirm ELISA specificity by immunoblot test (RIBA-HCV), and to evaluate HCV replication by serum HCV-RNA. Nine patients were anti-nuclear, three type 1 anti-liver-kidney microsomal and three anti-smooth muscle antibody positive. None had associated autoimmune disease. All cases showed mild clinical disease and only moderate necroinflammatory activity. Response to prednisone was poor. RIBA-HCV confirmed ELISA results in all patients. HCV-RNA was found in the serum from 10 patients. Institution of α-interferon treatment in three steroid non-responsive patients was followed by prompt normalization of transaminases. Thus, a subgroup of autoantibody-positive chronic active hepatitis can be recognized as HCV-related and should be clinically and etiologically distinguished from autoimmune chronic active hepatitis. 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Abdomen</subject><subject>Hepacivirus - genetics</subject><subject>Hepacivirus - isolation & purification</subject><subject>Hepacivirus - physiology</subject><subject>Hepatitis - immunology</subject><subject>Hepatitis - microbiology</subject><subject>Hepatitis - pathology</subject><subject>Hepatitis Antibodies - analysis</subject><subject>Hepatitis C - diagnosis</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C Antibodies</subject><subject>Humans</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Oligodeoxyribonucleotides</subject><subject>Polymerase Chain Reaction</subject><subject>RNA, Viral - genetics</subject><subject>RNA, Viral - isolation & purification</subject><subject>Virus Replication</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1KAzEQx4MoWj_eQGEPInpYnaTpJrkIUtQKihc9h2wySyP7UZPdgrc-hr6eT-LWVr15CAOZ33-Y-RFySOGcAs0u-idTyYQ8VfRMAUiWPmyQAc0AUsg43SSDX2SH7Mb4AgBDUHybbFPBRiOmBmQ8wZlpfetjMk7mPnQxCTgrve0_mzrxdfK5eDdd2_iq6mr8XHwkdhqa2ttk-pPcJ1uFKSMerOseeb65fhpP0vvH27vx1X1qhzJr0zwfsUI4yQtbGAFFnoPMHBiVSZCWMyNy4Qw3wqFjPLMOOWUuF1Rxga6A4R45Wc2dhea1w9jqykeLZWlqbLqoBcuU6K_tQb4CbWhiDFjoWfCVCW-agl6600sxeilGK6q_3emHPna0nt_lFbq_0EpW3z9e9020piyCqa2Pv9iIMiWo7LHLFYa9i7nHoKP1WFt0PqBttWv8_3t8ATZjjX4</recordid><startdate>19911101</startdate><enddate>19911101</enddate><creator>Magrin, Silvio</creator><creator>Craxi, Antonio</creator><creator>Fabiano, Carmelo</creator><creator>Fiorentino, Germana</creator><creator>Almasio, Piero</creator><creator>Palazzo, Ugo</creator><creator>Pinzello, Giovambattista</creator><creator>Provenzano, Giuseppe</creator><creator>Pagliaro, Luigi</creator><creator>Choo, Qui-Lim</creator><creator>Kuo, George</creator><creator>Polito, Alan</creator><creator>Han, Jang</creator><creator>Houghton, Michael</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19911101</creationdate><title>Hepatitis C virus replication in ‘autoimmune’ chronic hepatitis</title><author>Magrin, Silvio ; Craxi, Antonio ; Fabiano, Carmelo ; Fiorentino, Germana ; Almasio, Piero ; Palazzo, Ugo ; Pinzello, Giovambattista ; Provenzano, Giuseppe ; Pagliaro, Luigi ; Choo, Qui-Lim ; Kuo, George ; Polito, Alan ; Han, Jang ; Houghton, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-bb52f7d84fcfa70fbb086d0a96808c42a7b7da4a7ded246cde412db71947edf03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Autoantibodies - analysis</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. 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| identifier | ISSN: 0168-8278 |
| ispartof | Journal of hepatology, 1991-11, Vol.13 (3), p.364-367 |
| issn | 0168-8278 1600-0641 |
| language | eng |
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| subjects | Autoantibodies - analysis Base Sequence Biological and medical sciences Enzyme-Linked Immunosorbent Assay Female Gastroenterology. Liver. Pancreas. Abdomen Hepacivirus - genetics Hepacivirus - isolation & purification Hepacivirus - physiology Hepatitis - immunology Hepatitis - microbiology Hepatitis - pathology Hepatitis Antibodies - analysis Hepatitis C - diagnosis Hepatitis C - immunology Hepatitis C Antibodies Humans Liver - pathology Male Medical sciences Middle Aged Molecular Sequence Data Oligodeoxyribonucleotides Polymerase Chain Reaction RNA, Viral - genetics RNA, Viral - isolation & purification Virus Replication |
| title | Hepatitis C virus replication in ‘autoimmune’ chronic hepatitis |
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