Abnormal metabolic fate of nitric oxide in Type I diabetes mellitus

Reduced bioavailability of endothelium-derived nitric oxide is implicated in diabetic macrovascular and microvascular disease. In patients with diabetes, we hypothesised that protein glycosylation can alter nitric oxide binding affinity of haemoglobin and plasma proteins, hence reducing nitric oxide...

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Veröffentlicht in:	Diabetologia 2002-11, Vol.45 (11), p.1515-1522
Hauptverfasser:	MILSOM, A. B, JONES, C. J. H, GOODFELLOW, J, FRENNEAUX, M. P, PETERS, J. R, JAMES, P. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Associated diseases and complications Bioavailability Biological and medical sciences Biological Availability Blood Glucose - metabolism Blood Specimen Collection - methods Cholesterol - blood Diabetes Diabetes Mellitus, Type 1 - blood Diabetes. Impaired glucose tolerance Electron Spin Resonance Spectroscopy Endocrine pancreas. Apud cells (diseases) Endocrinopathies Glycated Hemoglobin A - metabolism Glycosylation Hemoglobin Hemoglobins - metabolism Humans Hypotheses Kinetics Medical sciences Metabolism Metabolites Molecular weight Nitrates Nitrates - blood Nitric oxide Nitric Oxide - blood Nitric Oxide - metabolism Nitric Oxide - pharmacokinetics Nitrites - blood Oxidation Plasma Proteins Triglycerides - blood
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