Elevated Skp2 protein expression in human prostate cancer: Association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival

The F-box protein Skp2 (Fbl1) is a positive regulator of G1-S transition and promotes ubiquitin-mediated proteolysis of the cyclin-dependent kinase inhibitor p27. Its overexpression has been implicated in cell transformation and oncogenesis in both in vitro and in vivo models. In this study, we inve...

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Veröffentlicht in:	Clinical cancer research 2002-11, Vol.8 (11), p.3419-3426
Hauptverfasser:	GUANG YANG, AYALA, Gustavo, DE MARZO, Angelo, WEIHUA TIAN, FROLOV, Anna, WHEELER, Thomas M, THOMPSON, Timothy C, HARPER, J. Wade
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Cycle Proteins - biosynthesis Cell Cycle Proteins - metabolism Cell Cycle Proteins - physiology Cyclin A - metabolism Cyclin-Dependent Kinase Inhibitor p27 Disease Progression Disease-Free Survival Epithelium - metabolism Humans Immunohistochemistry Male Medical sciences Nephrology. Urinary tract diseases Phosphoric Monoester Hydrolases - metabolism Phosphoric Monoester Hydrolases - physiology Prognosis Prostate - metabolism Prostatic Neoplasms - diagnosis Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology PTEN Phosphohydrolase S-Phase Kinase-Associated Proteins Time Factors Tumor Suppressor Proteins - metabolism Tumor Suppressor Proteins - physiology Tumors of the urinary system Urinary tract. Prostate gland
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