Antidepressant effects on kinase gene expression patterns in rat brain
Multiple kinase pathways determine serotonin transporter (SERT) regulation. We hypothesized a decrease in kinase expression with chronic selective serotonin reuptake inhibitor (SSRI) administration necessary to regulate extracellular serotonin. We studied whole brain kinase mRNA expression on Affyme...
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| Veröffentlicht in: | Neuroscience letters 2002-12, Vol.334 (2), p.91-94 |
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| container_title | Neuroscience letters |
| container_volume | 334 |
| creator | Rausch, J.L. Gillespie, C.F. Fei, Y. Hobby, H.M. Stoming, T. Ganapathy, V. Leibach, F.H. |
| description | Multiple kinase pathways determine serotonin transporter (SERT) regulation. We hypothesized a decrease in kinase expression with chronic selective serotonin reuptake inhibitor (SSRI) administration necessary to regulate extracellular serotonin. We studied whole brain kinase mRNA expression on Affymetrix gene chips in rats treated with placebo 3 and 21 days, fluoxetine 3 and 21 days, and citalopram 21 days. Protein kinase C (PKC)-delta, PKC-gamma, stress-activated protein kinase, cAMP-dependent protein kinase beta isoform, Janus protein kinase, and phosphofructokinase M were all down regulated chronically with citalopram and fluoxetine, but not with acute fluoxetine. The results are consistent with homeostasis of SERT function through a decrease in PK expression. |
| doi_str_mv | 10.1016/S0304-3940(02)01106-0 |
| format | Article |
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We hypothesized a decrease in kinase expression with chronic selective serotonin reuptake inhibitor (SSRI) administration necessary to regulate extracellular serotonin. We studied whole brain kinase mRNA expression on Affymetrix gene chips in rats treated with placebo 3 and 21 days, fluoxetine 3 and 21 days, and citalopram 21 days. Protein kinase C (PKC)-delta, PKC-gamma, stress-activated protein kinase, cAMP-dependent protein kinase beta isoform, Janus protein kinase, and phosphofructokinase M were all down regulated chronically with citalopram and fluoxetine, but not with acute fluoxetine. The results are consistent with homeostasis of SERT function through a decrease in PK expression.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(02)01106-0</identifier><identifier>PMID: 12435479</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Antidepressants ; Antidepressive Agents, Second-Generation - pharmacology ; Biological and medical sciences ; Brain - drug effects ; cAMP-mediated protein kinase ; Citalopram ; Citalopram - pharmacology ; Fluoxetine ; Fluoxetine - pharmacology ; Gene Expression Regulation ; Janus protein kinase ; kinase ; Male ; Medical sciences ; Neuropharmacology ; Oligonucleotide Array Sequence Analysis ; Pharmacology. Drug treatments ; Phosphofructokinase ; Phosphofructokinase M ; Phosphotransferases - drug effects ; Phosphotransferases - genetics ; Protein kinase ; Protein kinase C ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; RNA, Messenger - analysis ; Serotonin ; Serotonin transporter ; Serotonin uptake ; Stress-activated protein kinase ; Time Factors</subject><ispartof>Neuroscience letters, 2002-12, Vol.334 (2), p.91-94</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2002 Elsevier Science Ireland Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-c405eef2cde25d96062bfed0963f22929596ada33ad1347694c261a11267a3ad3</citedby><cites>FETCH-LOGICAL-c391t-c405eef2cde25d96062bfed0963f22929596ada33ad1347694c261a11267a3ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3940(02)01106-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14024072$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12435479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rausch, J.L.</creatorcontrib><creatorcontrib>Gillespie, C.F.</creatorcontrib><creatorcontrib>Fei, Y.</creatorcontrib><creatorcontrib>Hobby, H.M.</creatorcontrib><creatorcontrib>Stoming, T.</creatorcontrib><creatorcontrib>Ganapathy, V.</creatorcontrib><creatorcontrib>Leibach, F.H.</creatorcontrib><title>Antidepressant effects on kinase gene expression patterns in rat brain</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Multiple kinase pathways determine serotonin transporter (SERT) regulation. We hypothesized a decrease in kinase expression with chronic selective serotonin reuptake inhibitor (SSRI) administration necessary to regulate extracellular serotonin. We studied whole brain kinase mRNA expression on Affymetrix gene chips in rats treated with placebo 3 and 21 days, fluoxetine 3 and 21 days, and citalopram 21 days. Protein kinase C (PKC)-delta, PKC-gamma, stress-activated protein kinase, cAMP-dependent protein kinase beta isoform, Janus protein kinase, and phosphofructokinase M were all down regulated chronically with citalopram and fluoxetine, but not with acute fluoxetine. The results are consistent with homeostasis of SERT function through a decrease in PK expression.</description><subject>Animals</subject><subject>Antidepressants</subject><subject>Antidepressive Agents, Second-Generation - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>cAMP-mediated protein kinase</subject><subject>Citalopram</subject><subject>Citalopram - pharmacology</subject><subject>Fluoxetine</subject><subject>Fluoxetine - pharmacology</subject><subject>Gene Expression Regulation</subject><subject>Janus protein kinase</subject><subject>kinase</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphofructokinase</subject><subject>Phosphofructokinase M</subject><subject>Phosphotransferases - drug effects</subject><subject>Phosphotransferases - genetics</subject><subject>Protein kinase</subject><subject>Protein kinase C</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>RNA, Messenger - analysis</subject><subject>Serotonin</subject><subject>Serotonin transporter</subject><subject>Serotonin uptake</subject><subject>Stress-activated protein kinase</subject><subject>Time Factors</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MtKAzEUgOEgiq2XR1Bmo-hi9OQyiVlJKVaFggt1HdLkjETbTE2mom_v9IJdugocvpOEn5ATClcUqLx-Bg6i5FrABbBLoBRkCTukT28UK5VWbJf0_0iPHOT8DgAVrcQ-6VEmeCWU7pPRILbB4zxhzja2BdY1ujYXTSw-QrQZizeMWOD3SoRuPLdtiynmIsQi2baYJBviEdmr7TTj8eY8JK-ju5fhQzl-un8cDsal45q2pRNQIdbMeWSV1xIkm9ToQUteM6aZrrS03nJuPeVCSS0ck9RSyqSy3ZAfkvP1vfPUfC4wt2YWssPp1EZsFtkoJjVIUB2s1tClJueEtZmnMLPpx1Awy4BmFdAs6xhgZhXQQLd3unlgMZmh325tinXgbANsdnZaJxtdyFsngAlQrHO3a4ddjq-AyWQXMDr0IXWFjW_CP1_5BckbjC0</recordid><startdate>20021213</startdate><enddate>20021213</enddate><creator>Rausch, J.L.</creator><creator>Gillespie, C.F.</creator><creator>Fei, Y.</creator><creator>Hobby, H.M.</creator><creator>Stoming, T.</creator><creator>Ganapathy, V.</creator><creator>Leibach, F.H.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021213</creationdate><title>Antidepressant effects on kinase gene expression patterns in rat brain</title><author>Rausch, J.L. ; Gillespie, C.F. ; Fei, Y. ; Hobby, H.M. ; Stoming, T. ; Ganapathy, V. ; Leibach, F.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-c405eef2cde25d96062bfed0963f22929596ada33ad1347694c261a11267a3ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Antidepressants</topic><topic>Antidepressive Agents, Second-Generation - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>cAMP-mediated protein kinase</topic><topic>Citalopram</topic><topic>Citalopram - pharmacology</topic><topic>Fluoxetine</topic><topic>Fluoxetine - pharmacology</topic><topic>Gene Expression Regulation</topic><topic>Janus protein kinase</topic><topic>kinase</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Pharmacology. Drug treatments</topic><topic>Phosphofructokinase</topic><topic>Phosphofructokinase M</topic><topic>Phosphotransferases - drug effects</topic><topic>Phosphotransferases - genetics</topic><topic>Protein kinase</topic><topic>Protein kinase C</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>RNA, Messenger - analysis</topic><topic>Serotonin</topic><topic>Serotonin transporter</topic><topic>Serotonin uptake</topic><topic>Stress-activated protein kinase</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rausch, J.L.</creatorcontrib><creatorcontrib>Gillespie, C.F.</creatorcontrib><creatorcontrib>Fei, Y.</creatorcontrib><creatorcontrib>Hobby, H.M.</creatorcontrib><creatorcontrib>Stoming, T.</creatorcontrib><creatorcontrib>Ganapathy, V.</creatorcontrib><creatorcontrib>Leibach, F.H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rausch, J.L.</au><au>Gillespie, C.F.</au><au>Fei, Y.</au><au>Hobby, H.M.</au><au>Stoming, T.</au><au>Ganapathy, V.</au><au>Leibach, F.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antidepressant effects on kinase gene expression patterns in rat brain</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2002-12-13</date><risdate>2002</risdate><volume>334</volume><issue>2</issue><spage>91</spage><epage>94</epage><pages>91-94</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Multiple kinase pathways determine serotonin transporter (SERT) regulation. We hypothesized a decrease in kinase expression with chronic selective serotonin reuptake inhibitor (SSRI) administration necessary to regulate extracellular serotonin. We studied whole brain kinase mRNA expression on Affymetrix gene chips in rats treated with placebo 3 and 21 days, fluoxetine 3 and 21 days, and citalopram 21 days. Protein kinase C (PKC)-delta, PKC-gamma, stress-activated protein kinase, cAMP-dependent protein kinase beta isoform, Janus protein kinase, and phosphofructokinase M were all down regulated chronically with citalopram and fluoxetine, but not with acute fluoxetine. The results are consistent with homeostasis of SERT function through a decrease in PK expression.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>12435479</pmid><doi>10.1016/S0304-3940(02)01106-0</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Antidepressants Antidepressive Agents, Second-Generation - pharmacology Biological and medical sciences Brain - drug effects cAMP-mediated protein kinase Citalopram Citalopram - pharmacology Fluoxetine Fluoxetine - pharmacology Gene Expression Regulation Janus protein kinase kinase Male Medical sciences Neuropharmacology Oligonucleotide Array Sequence Analysis Pharmacology. Drug treatments Phosphofructokinase Phosphofructokinase M Phosphotransferases - drug effects Phosphotransferases - genetics Protein kinase Protein kinase C Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats RNA, Messenger - analysis Serotonin Serotonin transporter Serotonin uptake Stress-activated protein kinase Time Factors |
| title | Antidepressant effects on kinase gene expression patterns in rat brain |
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