Pertussis toxin and the adenylate cyclase toxin from Bordetella pertussis activate human monocyte-derived dendritic cells and dominantly inhibit cytokine production through a cAMP-dependent pathway

Pertussis toxin (PT) and adenylate cyclase toxin (AT) are AB enterotoxins produced by Bordetella pertussis. PT is a powerful mucosal adjuvant whose cellular target and mechanism of action are unknown; however, emerging evidence suggests that dendritic cells (DC) may be a principal adjuvant target of...

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Veröffentlicht in:	Journal of leukocyte biology 2002-11, Vol.72 (5), p.962-969
Hauptverfasser:	Bagley, Kenneth C., Abdelwahab, Sayed F., Tuskan, Robert G., Fouts, Timothy R., Lewis, George K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate Cyclase Toxin - pharmacology adjuvant Adjuvants, Immunologic - pharmacology Antigen Presentation Bordetella pertussis - pathogenicity CD4-Positive T-Lymphocytes - immunology Cell Differentiation - drug effects Cells, Cultured cholera toxin Cyclic AMP - physiology Cytokines - biosynthesis Dendritic Cells - drug effects Dendritic Cells - immunology Dose-Response Relationship, Drug enterotoxin Humans Interleukin-12 - biosynthesis Lipopolysaccharides - antagonists & inhibitors Lymphocyte Culture Test, Mixed Monocytes - immunology Pertussis Toxin - chemistry Pertussis Toxin - pharmacology Protein Structure, Tertiary Second Messenger Systems Tumor Necrosis Factor-alpha - biosynthesis
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