Oral administration of [3H]navelbine in patients: comparative pharmacokinetics using radioactive and radioimmunologic determination methods
[3H]Navelbine (NVB) was administered orally to two patients. Drug levels in biological fluids were monitored by radioimmunoassay (RIA) and direct radioactivity (RA) determinations. NVB absorption was rapidmaximum plasma concentrations appeared in the first 2 h after oral administrations. Pharmacokin...
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| Veröffentlicht in: | Anti-cancer drugs 1991-08, Vol.2 (4), p.405-410 |
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| creator | Rahmani, Roger Zhou, Xiao-Jian Boré, Patrick Cantfort, Jean Van Focan, Christian Cano, Jean-Paul |
| description | [3H]Navelbine (NVB) was administered orally to two patients. Drug levels in biological fluids were monitored by radioimmunoassay (RIA) and direct radioactivity (RA) determinations. NVB absorption was rapidmaximum plasma concentrations appeared in the first 2 h after oral administrations. Pharmacokinetic parameters estimated from RIA data were in complete accordance with those obtained from iv injections. Bioavailability (iv/po) estimated from RIA and RA data averaged 40.6 and 93.0%, respectively. NVB urine excretion was low. Fecal excretion remained its main elimination route. Moreover, large differences were observed in area under NVB plasma concentration-time curve (AUC) values obtained by the two methods, implying intense drug bio-transformations. |
| doi_str_mv | 10.1097/00001813-199108000-00011 |
| format | Article |
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Drug levels in biological fluids were monitored by radioimmunoassay (RIA) and direct radioactivity (RA) determinations. NVB absorption was rapidmaximum plasma concentrations appeared in the first 2 h after oral administrations. Pharmacokinetic parameters estimated from RIA data were in complete accordance with those obtained from iv injections. Bioavailability (iv/po) estimated from RIA and RA data averaged 40.6 and 93.0%, respectively. NVB urine excretion was low. Fecal excretion remained its main elimination route. Moreover, large differences were observed in area under NVB plasma concentration-time curve (AUC) values obtained by the two methods, implying intense drug bio-transformations.</description><identifier>ISSN: 0959-4973</identifier><identifier>EISSN: 1473-5741</identifier><identifier>DOI: 10.1097/00001813-199108000-00011</identifier><identifier>PMID: 1797198</identifier><language>eng</language><publisher>England: Lippincott-Raven Publishers</publisher><subject>Administration, Oral ; Aged ; Antineoplastic Agents - immunology ; Antineoplastic Agents - pharmacokinetics ; Biological Availability ; Chromatography, High Pressure Liquid ; Feces - chemistry ; Humans ; Intestinal Absorption ; Middle Aged ; Radioimmunoassay ; Tissue Distribution ; Vinblastine - analogs & derivatives ; Vinblastine - immunology ; Vinblastine - pharmacokinetics ; Vinorelbine</subject><ispartof>Anti-cancer drugs, 1991-08, Vol.2 (4), p.405-410</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1797198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rahmani, Roger</creatorcontrib><creatorcontrib>Zhou, Xiao-Jian</creatorcontrib><creatorcontrib>Boré, Patrick</creatorcontrib><creatorcontrib>Cantfort, Jean Van</creatorcontrib><creatorcontrib>Focan, Christian</creatorcontrib><creatorcontrib>Cano, Jean-Paul</creatorcontrib><title>Oral administration of [3H]navelbine in patients: comparative pharmacokinetics using radioactive and radioimmunologic determination methods</title><title>Anti-cancer drugs</title><addtitle>Anticancer Drugs</addtitle><description>[3H]Navelbine (NVB) was administered orally to two patients. Drug levels in biological fluids were monitored by radioimmunoassay (RIA) and direct radioactivity (RA) determinations. NVB absorption was rapidmaximum plasma concentrations appeared in the first 2 h after oral administrations. Pharmacokinetic parameters estimated from RIA data were in complete accordance with those obtained from iv injections. Bioavailability (iv/po) estimated from RIA and RA data averaged 40.6 and 93.0%, respectively. NVB urine excretion was low. Fecal excretion remained its main elimination route. Moreover, large differences were observed in area under NVB plasma concentration-time curve (AUC) values obtained by the two methods, implying intense drug bio-transformations.</description><subject>Administration, Oral</subject><subject>Aged</subject><subject>Antineoplastic Agents - immunology</subject><subject>Antineoplastic Agents - pharmacokinetics</subject><subject>Biological Availability</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Feces - chemistry</subject><subject>Humans</subject><subject>Intestinal Absorption</subject><subject>Middle Aged</subject><subject>Radioimmunoassay</subject><subject>Tissue Distribution</subject><subject>Vinblastine - analogs & derivatives</subject><subject>Vinblastine - immunology</subject><subject>Vinblastine - pharmacokinetics</subject><subject>Vinorelbine</subject><issn>0959-4973</issn><issn>1473-5741</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UU1v1TAQtBCovBZ-ApJP3AJ2nBfH3FAFFKlSL3BCyNrYmz5TfwQ7adXfwJ_GrylwwhdrZ2d2tDuEUM7ecKbkW1YfH7houFKcDbVqjgh_Qna8k6LZy44_JTum9qrplBTPyWkpPyql4uKEnHCpJFfDjvy6yuAp2OCiK0uGxaVI00S_iYvvEW7Rjy4idZHOtYVxKe-oSWGGI_MW6XyAHMCkm8panCl0LS5e0wzWJTAPFIh2q10Ia0w-XTtDLS6Yq-fmF3A5JFtekGcT-IIvH_8z8vXjhy_nF83l1afP5-8vGyPqjo2sSxmmhnboWzH1bc-Mle00yn5ANnHY49T3g7IVxVGJcY_StJ0FxaG1wkhxRl5vc-ecfq5YFh1cMeg9RExr0bKt8p6pShw2osmplIyTnrMLkO81Z_qYg_6Tg_6bg37IoUpfPXqsY0D7T7gdvva7rX-XfD1FufHrHWZ9QPDLQf8vXvEbMv-Wwg</recordid><startdate>199108</startdate><enddate>199108</enddate><creator>Rahmani, Roger</creator><creator>Zhou, Xiao-Jian</creator><creator>Boré, Patrick</creator><creator>Cantfort, Jean Van</creator><creator>Focan, Christian</creator><creator>Cano, Jean-Paul</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199108</creationdate><title>Oral administration of [3H]navelbine in patients: comparative pharmacokinetics using radioactive and radioimmunologic determination methods</title><author>Rahmani, Roger ; Zhou, Xiao-Jian ; Boré, Patrick ; Cantfort, Jean Van ; Focan, Christian ; Cano, Jean-Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3001-7959c09828623f6260cd72fb768e0f1a5ef6689dcd7eb93b5e7c24da91a2d3c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Administration, Oral</topic><topic>Aged</topic><topic>Antineoplastic Agents - immunology</topic><topic>Antineoplastic Agents - pharmacokinetics</topic><topic>Biological Availability</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Feces - chemistry</topic><topic>Humans</topic><topic>Intestinal Absorption</topic><topic>Middle Aged</topic><topic>Radioimmunoassay</topic><topic>Tissue Distribution</topic><topic>Vinblastine - analogs & derivatives</topic><topic>Vinblastine - immunology</topic><topic>Vinblastine - pharmacokinetics</topic><topic>Vinorelbine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rahmani, Roger</creatorcontrib><creatorcontrib>Zhou, Xiao-Jian</creatorcontrib><creatorcontrib>Boré, Patrick</creatorcontrib><creatorcontrib>Cantfort, Jean Van</creatorcontrib><creatorcontrib>Focan, Christian</creatorcontrib><creatorcontrib>Cano, Jean-Paul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anti-cancer drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rahmani, Roger</au><au>Zhou, Xiao-Jian</au><au>Boré, Patrick</au><au>Cantfort, Jean Van</au><au>Focan, Christian</au><au>Cano, Jean-Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral administration of [3H]navelbine in patients: comparative pharmacokinetics using radioactive and radioimmunologic determination methods</atitle><jtitle>Anti-cancer drugs</jtitle><addtitle>Anticancer Drugs</addtitle><date>1991-08</date><risdate>1991</risdate><volume>2</volume><issue>4</issue><spage>405</spage><epage>410</epage><pages>405-410</pages><issn>0959-4973</issn><eissn>1473-5741</eissn><abstract>[3H]Navelbine (NVB) was administered orally to two patients. Drug levels in biological fluids were monitored by radioimmunoassay (RIA) and direct radioactivity (RA) determinations. NVB absorption was rapidmaximum plasma concentrations appeared in the first 2 h after oral administrations. Pharmacokinetic parameters estimated from RIA data were in complete accordance with those obtained from iv injections. Bioavailability (iv/po) estimated from RIA and RA data averaged 40.6 and 93.0%, respectively. NVB urine excretion was low. Fecal excretion remained its main elimination route. Moreover, large differences were observed in area under NVB plasma concentration-time curve (AUC) values obtained by the two methods, implying intense drug bio-transformations.</abstract><cop>England</cop><pub>Lippincott-Raven Publishers</pub><pmid>1797198</pmid><doi>10.1097/00001813-199108000-00011</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0959-4973 |
| ispartof | Anti-cancer drugs, 1991-08, Vol.2 (4), p.405-410 |
| issn | 0959-4973 1473-5741 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Administration, Oral Aged Antineoplastic Agents - immunology Antineoplastic Agents - pharmacokinetics Biological Availability Chromatography, High Pressure Liquid Feces - chemistry Humans Intestinal Absorption Middle Aged Radioimmunoassay Tissue Distribution Vinblastine - analogs & derivatives Vinblastine - immunology Vinblastine - pharmacokinetics Vinorelbine |
| title | Oral administration of [3H]navelbine in patients: comparative pharmacokinetics using radioactive and radioimmunologic determination methods |
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