Cryotherapy of breast cancer under ultrasound guidance: initial results and limitations
The aim of this study was to investigate the potential and feasibility of ultrasound-guided cryotherapy in breast cancer. Fifteen female patients with 16 breast cancers (mean tumour diameter 21+/-7.8 mm) were treated. A 3-mm cryo probe was placed in the tumour under ultrasound guidance. Two freeze/t...
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| Veröffentlicht in: | European radiology 2002-12, Vol.12 (12), p.3009-3014 |
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| creator | Pfleiderer, Stefan O R Freesmeyer, Martin G Marx, Christiane Kühne-Heid, Rosemarie Schneider, Achim Kaiser, Werner A |
| description | The aim of this study was to investigate the potential and feasibility of ultrasound-guided cryotherapy in breast cancer. Fifteen female patients with 16 breast cancers (mean tumour diameter 21+/-7.8 mm) were treated. A 3-mm cryo probe was placed in the tumour under ultrasound guidance. Two freeze/thaw cycles with durations of 7-10 min and 5 min, respectively, were performed. The size of the iceballs was measured sonographically in 1-min intervals. The patients underwent surgery within 5 days and the specimens were evaluated histologically. The mean diameter of the iceball was 28+/-2.7 mm after the second freezing cycle. No severe side effects were observed. Five tumours with a diameter below 16 mm did not show any remaining invasive cancer after treatment. Two of these had ductal carcinoma in situ (DCIS) in the surrounding tissue. In 11 patients cryotherapy of tumours reaching diameters of 23 mm or more resulted in incomplete necrosis. This study shows that the invasive components of small tumours can be treated using cryotherapy. Remnant DCIS components which may not be detected preinterventionally represent a challenging problem for complete ablation. In tumours larger than 15 mm two or more cryo probes should be used to achieve larger iceballs. |
| doi_str_mv | 10.1007/s00330-002-1511-2 |
| format | Article |
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Fifteen female patients with 16 breast cancers (mean tumour diameter 21+/-7.8 mm) were treated. A 3-mm cryo probe was placed in the tumour under ultrasound guidance. Two freeze/thaw cycles with durations of 7-10 min and 5 min, respectively, were performed. The size of the iceballs was measured sonographically in 1-min intervals. The patients underwent surgery within 5 days and the specimens were evaluated histologically. The mean diameter of the iceball was 28+/-2.7 mm after the second freezing cycle. No severe side effects were observed. Five tumours with a diameter below 16 mm did not show any remaining invasive cancer after treatment. Two of these had ductal carcinoma in situ (DCIS) in the surrounding tissue. In 11 patients cryotherapy of tumours reaching diameters of 23 mm or more resulted in incomplete necrosis. This study shows that the invasive components of small tumours can be treated using cryotherapy. Remnant DCIS components which may not be detected preinterventionally represent a challenging problem for complete ablation. In tumours larger than 15 mm two or more cryo probes should be used to achieve larger iceballs.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-002-1511-2</identifier><identifier>PMID: 12439583</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Blood Pressure - physiology ; Breast cancer ; Breast Neoplasms - diagnosis ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Carcinoma ; Carcinoma, Ductal, Breast - diagnosis ; Carcinoma, Ductal, Breast - pathology ; Carcinoma, Ductal, Breast - surgery ; Carcinoma, Lobular - diagnosis ; Carcinoma, Lobular - pathology ; Carcinoma, Lobular - surgery ; Cryosurgery - instrumentation ; Cryosurgery - standards ; Cryotherapy ; Cryotherapy - instrumentation ; Cryotherapy - standards ; Device Removal ; Equipment Design - instrumentation ; Equipment Design - standards ; Feasibility Studies ; Female ; Freezing ; Heart Rate - physiology ; Humans ; Invasiveness ; Mammography ; Middle Aged ; Necrosis ; Neoplasm Invasiveness ; Oxygen Consumption - physiology ; Postoperative Complications - etiology ; Probes ; Side effects ; Surgery ; Temperature ; Time Factors ; Tumors ; Ultrasonography, Mammary - standards ; Ultrasound ; Women's Health</subject><ispartof>European radiology, 2002-12, Vol.12 (12), p.3009-3014</ispartof><rights>Springer-Verlag 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-51cadb8299820f17a477f26e5cb178077334ef2eee55a1bf824e8ae4718ab96f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12439583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pfleiderer, Stefan O R</creatorcontrib><creatorcontrib>Freesmeyer, Martin G</creatorcontrib><creatorcontrib>Marx, Christiane</creatorcontrib><creatorcontrib>Kühne-Heid, Rosemarie</creatorcontrib><creatorcontrib>Schneider, Achim</creatorcontrib><creatorcontrib>Kaiser, Werner A</creatorcontrib><title>Cryotherapy of breast cancer under ultrasound guidance: initial results and limitations</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><description>The aim of this study was to investigate the potential and feasibility of ultrasound-guided cryotherapy in breast cancer. Fifteen female patients with 16 breast cancers (mean tumour diameter 21+/-7.8 mm) were treated. A 3-mm cryo probe was placed in the tumour under ultrasound guidance. Two freeze/thaw cycles with durations of 7-10 min and 5 min, respectively, were performed. The size of the iceballs was measured sonographically in 1-min intervals. The patients underwent surgery within 5 days and the specimens were evaluated histologically. The mean diameter of the iceball was 28+/-2.7 mm after the second freezing cycle. No severe side effects were observed. Five tumours with a diameter below 16 mm did not show any remaining invasive cancer after treatment. Two of these had ductal carcinoma in situ (DCIS) in the surrounding tissue. In 11 patients cryotherapy of tumours reaching diameters of 23 mm or more resulted in incomplete necrosis. This study shows that the invasive components of small tumours can be treated using cryotherapy. Remnant DCIS components which may not be detected preinterventionally represent a challenging problem for complete ablation. In tumours larger than 15 mm two or more cryo probes should be used to achieve larger iceballs.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Blood Pressure - physiology</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - surgery</subject><subject>Carcinoma</subject><subject>Carcinoma, Ductal, Breast - diagnosis</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Carcinoma, Ductal, Breast - surgery</subject><subject>Carcinoma, Lobular - diagnosis</subject><subject>Carcinoma, Lobular - pathology</subject><subject>Carcinoma, Lobular - surgery</subject><subject>Cryosurgery - instrumentation</subject><subject>Cryosurgery - standards</subject><subject>Cryotherapy</subject><subject>Cryotherapy - instrumentation</subject><subject>Cryotherapy - standards</subject><subject>Device Removal</subject><subject>Equipment Design - instrumentation</subject><subject>Equipment Design - standards</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Freezing</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Invasiveness</subject><subject>Mammography</subject><subject>Middle Aged</subject><subject>Necrosis</subject><subject>Neoplasm Invasiveness</subject><subject>Oxygen Consumption - physiology</subject><subject>Postoperative Complications - etiology</subject><subject>Probes</subject><subject>Side effects</subject><subject>Surgery</subject><subject>Temperature</subject><subject>Time Factors</subject><subject>Tumors</subject><subject>Ultrasonography, Mammary - standards</subject><subject>Ultrasound</subject><subject>Women's Health</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1Lw0AQhhdRbK3-AC8SPIiX6Mx-dDfepPgFBS-Kx2WTTnRLmtTd5NB_75YWBA9eZhjeZwaGh7FzhBsE0LcRQAjIAXiOCjHnB2yMUqQJjDxkYyiEyXVRyBE7iXEJAAVKfcxGyKUolBFj9jELm67_ouDWm6yrszKQi31WubaikA3tYlubPrjYpSH7HPxiG91lvvW9d00WKKY8Zi6ljV_53vW-a-MpO6pdE-ls3yfs_fHhbfacz1-fXmb387ySXPS5wsotSsOLwnCoUTupdc2npKoStQGthZBUcyJSymFZGy7JOJIajSuLaS0m7Gp3dx2674Fib1c-VtQ0rqVuiFbzqdFGYwKv_wWRc0RhlNAJvfyDLrshtOkNa4ycKmUUJAh3UBW6GAPVdh38yoWNRbBbO3ZnxyY7dmvH8rRzsT88lCta_G7sdYgfttKKZg</recordid><startdate>200212</startdate><enddate>200212</enddate><creator>Pfleiderer, Stefan O R</creator><creator>Freesmeyer, Martin G</creator><creator>Marx, Christiane</creator><creator>Kühne-Heid, Rosemarie</creator><creator>Schneider, Achim</creator><creator>Kaiser, Werner A</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200212</creationdate><title>Cryotherapy of breast cancer under ultrasound guidance: initial results and limitations</title><author>Pfleiderer, Stefan O R ; Freesmeyer, Martin G ; Marx, Christiane ; Kühne-Heid, Rosemarie ; Schneider, Achim ; Kaiser, Werner A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-51cadb8299820f17a477f26e5cb178077334ef2eee55a1bf824e8ae4718ab96f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Blood Pressure - 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Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pfleiderer, Stefan O R</au><au>Freesmeyer, Martin G</au><au>Marx, Christiane</au><au>Kühne-Heid, Rosemarie</au><au>Schneider, Achim</au><au>Kaiser, Werner A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cryotherapy of breast cancer under ultrasound guidance: initial results and limitations</atitle><jtitle>European radiology</jtitle><addtitle>Eur Radiol</addtitle><date>2002-12</date><risdate>2002</risdate><volume>12</volume><issue>12</issue><spage>3009</spage><epage>3014</epage><pages>3009-3014</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>The aim of this study was to investigate the potential and feasibility of ultrasound-guided cryotherapy in breast cancer. Fifteen female patients with 16 breast cancers (mean tumour diameter 21+/-7.8 mm) were treated. A 3-mm cryo probe was placed in the tumour under ultrasound guidance. Two freeze/thaw cycles with durations of 7-10 min and 5 min, respectively, were performed. The size of the iceballs was measured sonographically in 1-min intervals. The patients underwent surgery within 5 days and the specimens were evaluated histologically. The mean diameter of the iceball was 28+/-2.7 mm after the second freezing cycle. No severe side effects were observed. Five tumours with a diameter below 16 mm did not show any remaining invasive cancer after treatment. Two of these had ductal carcinoma in situ (DCIS) in the surrounding tissue. In 11 patients cryotherapy of tumours reaching diameters of 23 mm or more resulted in incomplete necrosis. This study shows that the invasive components of small tumours can be treated using cryotherapy. Remnant DCIS components which may not be detected preinterventionally represent a challenging problem for complete ablation. In tumours larger than 15 mm two or more cryo probes should be used to achieve larger iceballs.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>12439583</pmid><doi>10.1007/s00330-002-1511-2</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Blood Pressure - physiology Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - pathology Breast Neoplasms - surgery Carcinoma Carcinoma, Ductal, Breast - diagnosis Carcinoma, Ductal, Breast - pathology Carcinoma, Ductal, Breast - surgery Carcinoma, Lobular - diagnosis Carcinoma, Lobular - pathology Carcinoma, Lobular - surgery Cryosurgery - instrumentation Cryosurgery - standards Cryotherapy Cryotherapy - instrumentation Cryotherapy - standards Device Removal Equipment Design - instrumentation Equipment Design - standards Feasibility Studies Female Freezing Heart Rate - physiology Humans Invasiveness Mammography Middle Aged Necrosis Neoplasm Invasiveness Oxygen Consumption - physiology Postoperative Complications - etiology Probes Side effects Surgery Temperature Time Factors Tumors Ultrasonography, Mammary - standards Ultrasound Women's Health |
| title | Cryotherapy of breast cancer under ultrasound guidance: initial results and limitations |
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