Effects of kamikihi-to, a Chinese traditional medicine, on various cholinergic biochemical markers in the brains of aged rats
The effects of kamikihi-to (EK-49) on various cholinergic biochemical markers, muscarinic receptors, acetylcholinesterase (AChE), choline acetyltransferase (CAT) and choline uptake, in aged rat brains were examined. Administration of kamikihi-to in daily doses of 200 mg/kg, p.o. for 4 weeks to aged...
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| Veröffentlicht in: | Folia Pharmacologica Japonica 1991, Vol.98(4), pp.273-281 |
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| container_title | Folia Pharmacologica Japonica |
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| creator | EGASHIRA, Toru SUDO, Shinji MURAYAMA, Fumie KONO, Toshiro KUDO, Yoshikuni GOTO, Shinichiro TAKAYAMA, Fusako YAMANAKA, Yasumitsu |
| description | The effects of kamikihi-to (EK-49) on various cholinergic biochemical markers, muscarinic receptors, acetylcholinesterase (AChE), choline acetyltransferase (CAT) and choline uptake, in aged rat brains were examined. Administration of kamikihi-to in daily doses of 200 mg/kg, p.o. for 4 weeks to aged rats (24-months-old) significantly increased the density of muscarinic receptors (Bmax) for 3H-QNB (quinuclidinyl benzilate), but did not affect the apparent dissociation constant (Kd). After repeated administration of kamikihi-to to aged rats, AChE activity and choline uptake were not significantly different in the kamikihi-to treated aged rats as compared with the control aged rats. However, administration of kamikihi-to for 4 weeks resulted in a significant increase in Vmax values of CAT in kamikihi-to treated aged rats as compared with those of the control rats. These results indicate that long-term treatment with kamikihi-to enhances both the Bmax and Vmax for QNB binding and CAT activity in aged rats, respectively. |
| doi_str_mv | 10.1254/fpj.98.4_273 |
| format | Article |
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Administration of kamikihi-to in daily doses of 200 mg/kg, p.o. for 4 weeks to aged rats (24-months-old) significantly increased the density of muscarinic receptors (Bmax) for 3H-QNB (quinuclidinyl benzilate), but did not affect the apparent dissociation constant (Kd). After repeated administration of kamikihi-to to aged rats, AChE activity and choline uptake were not significantly different in the kamikihi-to treated aged rats as compared with the control aged rats. However, administration of kamikihi-to for 4 weeks resulted in a significant increase in Vmax values of CAT in kamikihi-to treated aged rats as compared with those of the control rats. These results indicate that long-term treatment with kamikihi-to enhances both the Bmax and Vmax for QNB binding and CAT activity in aged rats, respectively.</description><identifier>ISSN: 0015-5691</identifier><identifier>EISSN: 1347-8397</identifier><identifier>DOI: 10.1254/fpj.98.4_273</identifier><identifier>PMID: 1802814</identifier><language>jpn</language><publisher>Japan: The Japanese Pharmacological Society</publisher><subject>Acetylcholinesterase - metabolism ; Aging - physiology ; Animals ; Brain - drug effects ; Brain - metabolism ; Choline - metabolism ; Choline O-Acetyltransferase - metabolism ; Drugs, Chinese Herbal - pharmacology ; Male ; Rats ; Rats, Inbred Strains ; Receptors, Muscarinic - drug effects</subject><ispartof>Folia Pharmacologica Japonica, 1991, Vol.98(4), pp.273-281</ispartof><rights>The Japanese PharmacologicalSociety</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-7d2d8538bbbd87f780e747579e0399a3bcaf7ba143e4624d80a7e09bb3297b293</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1802814$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>EGASHIRA, Toru</creatorcontrib><creatorcontrib>SUDO, Shinji</creatorcontrib><creatorcontrib>MURAYAMA, Fumie</creatorcontrib><creatorcontrib>KONO, Toshiro</creatorcontrib><creatorcontrib>KUDO, Yoshikuni</creatorcontrib><creatorcontrib>GOTO, Shinichiro</creatorcontrib><creatorcontrib>TAKAYAMA, Fusako</creatorcontrib><creatorcontrib>YAMANAKA, Yasumitsu</creatorcontrib><title>Effects of kamikihi-to, a Chinese traditional medicine, on various cholinergic biochemical markers in the brains of aged rats</title><title>Folia Pharmacologica Japonica</title><addtitle>Nihon Yakurigaku Zasshi</addtitle><description>The effects of kamikihi-to (EK-49) on various cholinergic biochemical markers, muscarinic receptors, acetylcholinesterase (AChE), choline acetyltransferase (CAT) and choline uptake, in aged rat brains were examined. Administration of kamikihi-to in daily doses of 200 mg/kg, p.o. for 4 weeks to aged rats (24-months-old) significantly increased the density of muscarinic receptors (Bmax) for 3H-QNB (quinuclidinyl benzilate), but did not affect the apparent dissociation constant (Kd). After repeated administration of kamikihi-to to aged rats, AChE activity and choline uptake were not significantly different in the kamikihi-to treated aged rats as compared with the control aged rats. However, administration of kamikihi-to for 4 weeks resulted in a significant increase in Vmax values of CAT in kamikihi-to treated aged rats as compared with those of the control rats. These results indicate that long-term treatment with kamikihi-to enhances both the Bmax and Vmax for QNB binding and CAT activity in aged rats, respectively.</description><subject>Acetylcholinesterase - metabolism</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Choline - metabolism</subject><subject>Choline O-Acetyltransferase - metabolism</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Muscarinic - drug effects</subject><issn>0015-5691</issn><issn>1347-8397</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtPGzEUhS3UCiLKji2SV6wyqV8T28sq4lEJqRtYW7bnDmMyGae2g9QF_70OQ-nK0j2fjnU-hC4pWVHWiu_9_mWl1UoYJvkJWlAuZKO4ll_QghDaNu1a0zN0kXNwhLSSyTWnp-iUKsIUFQv0dtP34EvGscdbuwvbMISmxCW2eDOECTLgkmwXSoiTHfEOuuDreYnjhF9tCvGQsR_iWG_pOXjsQvQD7II_wjZtIWUcJlwGwC7ZML1_ZJ-hw8mW_A197e2Y4eLjPUdPtzePm_vm4dfdz82Ph8YLQUsjO9aplivnXKdkLxUBKWQrNRCuteXO2146SwUHsWaiU8RKINo5zrR0TPNzdD337lP8fYBczC5kD-NoJ6gLjGRrJVstK7icQZ9izgl6s0-h7vhjKDFH4aYKN1qZd-EVv_roPbiq5j886635Zs5fcqmjP3ObSvAjHMuoFmIu_Nf6mfrBJgMT_wvkb5Us</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>EGASHIRA, Toru</creator><creator>SUDO, Shinji</creator><creator>MURAYAMA, Fumie</creator><creator>KONO, Toshiro</creator><creator>KUDO, Yoshikuni</creator><creator>GOTO, Shinichiro</creator><creator>TAKAYAMA, Fusako</creator><creator>YAMANAKA, Yasumitsu</creator><general>The Japanese Pharmacological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1991</creationdate><title>Effects of kamikihi-to, a Chinese traditional medicine, on various cholinergic biochemical markers in the brains of aged rats</title><author>EGASHIRA, Toru ; SUDO, Shinji ; MURAYAMA, Fumie ; KONO, Toshiro ; KUDO, Yoshikuni ; GOTO, Shinichiro ; TAKAYAMA, Fusako ; YAMANAKA, Yasumitsu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-7d2d8538bbbd87f780e747579e0399a3bcaf7ba143e4624d80a7e09bb3297b293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1991</creationdate><topic>Acetylcholinesterase - metabolism</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Choline - metabolism</topic><topic>Choline O-Acetyltransferase - metabolism</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Muscarinic - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EGASHIRA, Toru</creatorcontrib><creatorcontrib>SUDO, Shinji</creatorcontrib><creatorcontrib>MURAYAMA, Fumie</creatorcontrib><creatorcontrib>KONO, Toshiro</creatorcontrib><creatorcontrib>KUDO, Yoshikuni</creatorcontrib><creatorcontrib>GOTO, Shinichiro</creatorcontrib><creatorcontrib>TAKAYAMA, Fusako</creatorcontrib><creatorcontrib>YAMANAKA, Yasumitsu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Folia Pharmacologica Japonica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EGASHIRA, Toru</au><au>SUDO, Shinji</au><au>MURAYAMA, Fumie</au><au>KONO, Toshiro</au><au>KUDO, Yoshikuni</au><au>GOTO, Shinichiro</au><au>TAKAYAMA, Fusako</au><au>YAMANAKA, Yasumitsu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of kamikihi-to, a Chinese traditional medicine, on various cholinergic biochemical markers in the brains of aged rats</atitle><jtitle>Folia Pharmacologica Japonica</jtitle><addtitle>Nihon Yakurigaku Zasshi</addtitle><date>1991</date><risdate>1991</risdate><volume>98</volume><issue>4</issue><spage>273</spage><epage>281</epage><pages>273-281</pages><issn>0015-5691</issn><eissn>1347-8397</eissn><abstract>The effects of kamikihi-to (EK-49) on various cholinergic biochemical markers, muscarinic receptors, acetylcholinesterase (AChE), choline acetyltransferase (CAT) and choline uptake, in aged rat brains were examined. Administration of kamikihi-to in daily doses of 200 mg/kg, p.o. for 4 weeks to aged rats (24-months-old) significantly increased the density of muscarinic receptors (Bmax) for 3H-QNB (quinuclidinyl benzilate), but did not affect the apparent dissociation constant (Kd). After repeated administration of kamikihi-to to aged rats, AChE activity and choline uptake were not significantly different in the kamikihi-to treated aged rats as compared with the control aged rats. However, administration of kamikihi-to for 4 weeks resulted in a significant increase in Vmax values of CAT in kamikihi-to treated aged rats as compared with those of the control rats. These results indicate that long-term treatment with kamikihi-to enhances both the Bmax and Vmax for QNB binding and CAT activity in aged rats, respectively.</abstract><cop>Japan</cop><pub>The Japanese Pharmacological Society</pub><pmid>1802814</pmid><doi>10.1254/fpj.98.4_273</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Folia Pharmacologica Japonica, 1991, Vol.98(4), pp.273-281 |
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| source | MEDLINE; EZB Electronic Journals Library |
| subjects | Acetylcholinesterase - metabolism Aging - physiology Animals Brain - drug effects Brain - metabolism Choline - metabolism Choline O-Acetyltransferase - metabolism Drugs, Chinese Herbal - pharmacology Male Rats Rats, Inbred Strains Receptors, Muscarinic - drug effects |
| title | Effects of kamikihi-to, a Chinese traditional medicine, on various cholinergic biochemical markers in the brains of aged rats |
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