Human colorectal adenomas demonstrate a size-dependent increase in epithelial cyclooxygenase-2 expression

Non‐steroidal anti‐inflammatory drugs are chemopreventive for colorectal cancer. This effect is due in part to their ability to inhibit the inducible isoform of cyclooxygenase (COX‐2). However, the cellular expression and role of COX‐2 in the premalignant stages of colorectal tumourigenesis is uncle...

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Veröffentlicht in:	The Journal of pathology 2002-12, Vol.198 (4), p.428-434
Hauptverfasser:	Elder, Douglas JE, Baker, Jenny A, Banu, Nahida A, Moorghen, Moganaden, Paraskeva, Christos
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - enzymology adenoma Adenoma - enzymology Adenoma - pathology Biological and medical sciences Colorectal Colorectal Neoplasms - enzymology Colorectal Neoplasms - pathology Cyclooxygenase 2 Disease Progression Epithelial Cells - enzymology Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques immunohistochemistry Intestinal Mucosa - enzymology Isoenzymes - metabolism Medical sciences Membrane Proteins Prostaglandin-Endoperoxide Synthases - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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