Human Papilloma Virus 16 E6 Oncoprotein Inhibits Retinoic X Receptor-mediated Transactivation by Targeting Human ADA3 Coactivator

The expression of human papillomavirus (HPV) E6 oncoprotein is causally linked to high-risk HPV-associated human cancers. We have recently isolated hADA3, the human homologue of yeast transcriptional co-activator yADA3, as a novel E6 target. Human ADA3 binds to the high-risk (cancer-associated) but...

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Veröffentlicht in:	The Journal of biological chemistry 2002-11, Vol.277 (47), p.45611-45618
Hauptverfasser:	Zeng, Musheng, Kumar, Ajay, Meng, Gaoyuan, Gao, Qingshen, Dimri, Goberdhan, Wazer, David, Band, Hamid, Band, Vimla
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Gene Expression Regulation Genes, Reporter Humans Macromolecular Substances Oncogene Proteins, Viral - metabolism Papillomaviridae - metabolism Promoter Regions, Genetic Protein Binding Receptors, Retinoic Acid - genetics Receptors, Retinoic Acid - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Repressor Proteins - metabolism Retinoic Acid Receptor alpha Retinoid X Receptors Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation Tumor Cells, Cultured
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