The waste-product theory of aging: Simulation of metabolic waste production
A mathematical model of cellular metabolism is used to relate the rates of cell division and waste production to the concentrations of oxygen and glucose in medium in which a normal diploid cell culture is grown. The metabolic model in tandem with an earlier waste-content model based on the waste-pr...
Gespeichert in:
| Veröffentlicht in: | Experimental gerontology 1991, Vol.26 (6), p.549-567 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 567 |
|---|---|
| container_issue | 6 |
| container_start_page | 549 |
| container_title | Experimental gerontology |
| container_volume | 26 |
| creator | Hirsch, H.R. Witten, M. |
| description | A mathematical model of cellular metabolism is used to relate the rates of cell division and waste production to the concentrations of oxygen and glucose in medium in which a normal diploid cell culture is grown. The metabolic model in tandem with an earlier waste-content model based on the waste-product theory of aging provides a unified cell-culture model with which population size and intracellular waste content can be calculated. Population size is measured by the number of population doublings which have been achieved. After suitable adjustment of parameters in the metabolic model, maximum values of population size are calculated numerically with the use of the unified model. Results show that the population maxima are related in a plausible way to the oxygen and glucose concentrations. The effects of temperature changes and contact inhibition of growth are also simulated. Small changes in the cell-division and waste-production rates can cause transformation to unlimited growth in the waste-content model, but the unified model is not correspondingly sensitive to changes in the oxygen and glucose concentrations or to changes in temperature. |
| doi_str_mv | 10.1016/0531-5565(91)90073-U |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72687034</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>053155659190073U</els_id><sourcerecordid>72687034</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-d572d4474ae00502bbaf6bdc7ddc90d3668da06266ce7d55000b5d7da946aedd3</originalsourceid><addsrcrecordid>eNp9kE1LxDAURYMoOo7-A4UuRHRRfWmbpHUhiPiFgguddUiTVyfSjzFpFf-9GTuMO1cJeee-XA4hBxTOKFB-DiylMWOcnRT0tAAQaTzbIBOahwvPKdskkzWyQ3a9fwcAnqR0m2zTHICmMCGPr3OMvpTvMV64zgy6j_o5du476qpIvdn27SJ6sc1Qq9527fKxwV6VXW31GItWsTDdI1uVqj3ur84pmd3evF7fx0_Pdw_XV0-xzlLRx4aJxGSZyBQCMEjKUlW8NFoYowswKee5UaEo5xqFYSy0LpkRRhUZV2hMOiXH497w9ceAvpeN9RrrWrXYDV6KhOcC0iyA2Qhq13nvsJILZxvlviUFuXQol4LkUpAsqPx1KGchdrjaP5QNmr_QKC3Mj1Zz5bWqK6dabf0aYzTJoBABuxwxDC4-LTrptcVWo7EOdS9NZ__v8QPi0Y3X</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72687034</pqid></control><display><type>article</type><title>The waste-product theory of aging: Simulation of metabolic waste production</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Hirsch, H.R. ; Witten, M.</creator><creatorcontrib>Hirsch, H.R. ; Witten, M.</creatorcontrib><description>A mathematical model of cellular metabolism is used to relate the rates of cell division and waste production to the concentrations of oxygen and glucose in medium in which a normal diploid cell culture is grown. The metabolic model in tandem with an earlier waste-content model based on the waste-product theory of aging provides a unified cell-culture model with which population size and intracellular waste content can be calculated. Population size is measured by the number of population doublings which have been achieved. After suitable adjustment of parameters in the metabolic model, maximum values of population size are calculated numerically with the use of the unified model. Results show that the population maxima are related in a plausible way to the oxygen and glucose concentrations. The effects of temperature changes and contact inhibition of growth are also simulated. Small changes in the cell-division and waste-production rates can cause transformation to unlimited growth in the waste-content model, but the unified model is not correspondingly sensitive to changes in the oxygen and glucose concentrations or to changes in temperature.</description><identifier>ISSN: 0531-5565</identifier><identifier>EISSN: 1873-6815</identifier><identifier>DOI: 10.1016/0531-5565(91)90073-U</identifier><identifier>PMID: 1800130</identifier><identifier>CODEN: EXGEAB</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>aging ; Biological and medical sciences ; Cell Division ; Cell Line ; cellular metabolism ; Cellular Senescence - physiology ; Contact Inhibition ; Development. Metamorphosis. Moult. Ageing ; Fundamental and applied biological sciences. Psychology ; Glucose - metabolism ; Humans ; Kinetics ; Models, Biological ; Oxygen - metabolism ; Temperature ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; waste production ; waste-product theory</subject><ispartof>Experimental gerontology, 1991, Vol.26 (6), p.549-567</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-d572d4474ae00502bbaf6bdc7ddc90d3668da06266ce7d55000b5d7da946aedd3</citedby><cites>FETCH-LOGICAL-c437t-d572d4474ae00502bbaf6bdc7ddc90d3668da06266ce7d55000b5d7da946aedd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/053155659190073U$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5124097$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1800130$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirsch, H.R.</creatorcontrib><creatorcontrib>Witten, M.</creatorcontrib><title>The waste-product theory of aging: Simulation of metabolic waste production</title><title>Experimental gerontology</title><addtitle>Exp Gerontol</addtitle><description>A mathematical model of cellular metabolism is used to relate the rates of cell division and waste production to the concentrations of oxygen and glucose in medium in which a normal diploid cell culture is grown. The metabolic model in tandem with an earlier waste-content model based on the waste-product theory of aging provides a unified cell-culture model with which population size and intracellular waste content can be calculated. Population size is measured by the number of population doublings which have been achieved. After suitable adjustment of parameters in the metabolic model, maximum values of population size are calculated numerically with the use of the unified model. Results show that the population maxima are related in a plausible way to the oxygen and glucose concentrations. The effects of temperature changes and contact inhibition of growth are also simulated. Small changes in the cell-division and waste-production rates can cause transformation to unlimited growth in the waste-content model, but the unified model is not correspondingly sensitive to changes in the oxygen and glucose concentrations or to changes in temperature.</description><subject>aging</subject><subject>Biological and medical sciences</subject><subject>Cell Division</subject><subject>Cell Line</subject><subject>cellular metabolism</subject><subject>Cellular Senescence - physiology</subject><subject>Contact Inhibition</subject><subject>Development. Metamorphosis. Moult. Ageing</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Models, Biological</subject><subject>Oxygen - metabolism</subject><subject>Temperature</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>waste production</subject><subject>waste-product theory</subject><issn>0531-5565</issn><issn>1873-6815</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAURYMoOo7-A4UuRHRRfWmbpHUhiPiFgguddUiTVyfSjzFpFf-9GTuMO1cJeee-XA4hBxTOKFB-DiylMWOcnRT0tAAQaTzbIBOahwvPKdskkzWyQ3a9fwcAnqR0m2zTHICmMCGPr3OMvpTvMV64zgy6j_o5du476qpIvdn27SJ6sc1Qq9527fKxwV6VXW31GItWsTDdI1uVqj3ur84pmd3evF7fx0_Pdw_XV0-xzlLRx4aJxGSZyBQCMEjKUlW8NFoYowswKee5UaEo5xqFYSy0LpkRRhUZV2hMOiXH497w9ceAvpeN9RrrWrXYDV6KhOcC0iyA2Qhq13nvsJILZxvlviUFuXQol4LkUpAsqPx1KGchdrjaP5QNmr_QKC3Mj1Zz5bWqK6dabf0aYzTJoBABuxwxDC4-LTrptcVWo7EOdS9NZ__v8QPi0Y3X</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Hirsch, H.R.</creator><creator>Witten, M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1991</creationdate><title>The waste-product theory of aging: Simulation of metabolic waste production</title><author>Hirsch, H.R. ; Witten, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-d572d4474ae00502bbaf6bdc7ddc90d3668da06266ce7d55000b5d7da946aedd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>aging</topic><topic>Biological and medical sciences</topic><topic>Cell Division</topic><topic>Cell Line</topic><topic>cellular metabolism</topic><topic>Cellular Senescence - physiology</topic><topic>Contact Inhibition</topic><topic>Development. Metamorphosis. Moult. Ageing</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Models, Biological</topic><topic>Oxygen - metabolism</topic><topic>Temperature</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>waste production</topic><topic>waste-product theory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirsch, H.R.</creatorcontrib><creatorcontrib>Witten, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental gerontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirsch, H.R.</au><au>Witten, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The waste-product theory of aging: Simulation of metabolic waste production</atitle><jtitle>Experimental gerontology</jtitle><addtitle>Exp Gerontol</addtitle><date>1991</date><risdate>1991</risdate><volume>26</volume><issue>6</issue><spage>549</spage><epage>567</epage><pages>549-567</pages><issn>0531-5565</issn><eissn>1873-6815</eissn><coden>EXGEAB</coden><abstract>A mathematical model of cellular metabolism is used to relate the rates of cell division and waste production to the concentrations of oxygen and glucose in medium in which a normal diploid cell culture is grown. The metabolic model in tandem with an earlier waste-content model based on the waste-product theory of aging provides a unified cell-culture model with which population size and intracellular waste content can be calculated. Population size is measured by the number of population doublings which have been achieved. After suitable adjustment of parameters in the metabolic model, maximum values of population size are calculated numerically with the use of the unified model. Results show that the population maxima are related in a plausible way to the oxygen and glucose concentrations. The effects of temperature changes and contact inhibition of growth are also simulated. Small changes in the cell-division and waste-production rates can cause transformation to unlimited growth in the waste-content model, but the unified model is not correspondingly sensitive to changes in the oxygen and glucose concentrations or to changes in temperature.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>1800130</pmid><doi>10.1016/0531-5565(91)90073-U</doi><tpages>19</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0531-5565 |
| ispartof | Experimental gerontology, 1991, Vol.26 (6), p.549-567 |
| issn | 0531-5565 1873-6815 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72687034 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | aging Biological and medical sciences Cell Division Cell Line cellular metabolism Cellular Senescence - physiology Contact Inhibition Development. Metamorphosis. Moult. Ageing Fundamental and applied biological sciences. Psychology Glucose - metabolism Humans Kinetics Models, Biological Oxygen - metabolism Temperature Vertebrates: anatomy and physiology, studies on body, several organs or systems waste production waste-product theory |
| title | The waste-product theory of aging: Simulation of metabolic waste production |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T14%3A45%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20waste-product%20theory%20of%20aging:%20Simulation%20of%20metabolic%20waste%20production&rft.jtitle=Experimental%20gerontology&rft.au=Hirsch,%20H.R.&rft.date=1991&rft.volume=26&rft.issue=6&rft.spage=549&rft.epage=567&rft.pages=549-567&rft.issn=0531-5565&rft.eissn=1873-6815&rft.coden=EXGEAB&rft_id=info:doi/10.1016/0531-5565(91)90073-U&rft_dat=%3Cproquest_cross%3E72687034%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72687034&rft_id=info:pmid/1800130&rft_els_id=053155659190073U&rfr_iscdi=true |